HTR1B - 5-hydroxytryptamine receptor 1B Gene

Homo sapiens

Also known as S12; 5-HT1B; HTR1D2; HTR1DB; 5-HT-1B; 5-HT1DB; 5-HT-1D-beta

Gene ID: 3351 | Gene type: protein coding

About HTR1B

Cytogenetic location: 6q14.1 Genomic coordinates (GRCh38): 6:77,460,924-77,463,491 (from NCBI)

This gene has 1 transcript (splice variant), 246 orthologues and 8 paralogues.

Summary

The protein encoded by this intronless gene is a G-protein coupled receptor for serotonin (5-hydroxytryptamine). Ligand binding activates second messengers that inhibit the activity of Adenylate Cyclase and manage the release of serotonin, dopamine, and acetylcholine in the brain. The encoded protein may be involved in several neuropsychiatric disorders and therefore is often a target of antidepressant and Other psychotherapeutic drugs. [provided by RefSeq, Nov 2015]

HTR1B Products(1)

mRNA	Protein	Name
NM_000863.3	NP_000854.1	5-hydroxytryptamine receptor 1B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled serotonin receptor activity	IDA IDA: Inferred from direct assay	1315531	GOA
enables Gi/o-coupled serotonin receptor activity	IDA IDA: Inferred from direct assay	1348246	GOA
enables Gi/o-coupled serotonin receptor activity	IMP IMP: Inferred from mutant phenotype	29925951	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24722188	GOA
enables serotonin receptor activity	IMP IMP: Inferred from mutant phenotype	29925951	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	8882600	GOA
involved in adenylate cyclase-inhibiting serotonin receptor signaling pathway	IDA IDA: Inferred from direct assay	1315531	GOA
involved in cellular response to alkaloid	IDA IDA: Inferred from direct assay	1315531	GOA
involved in cellular response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	1315531	GOA
involved in positive regulation of vascular associated smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	25871906	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in plasma membrane	IDA IDA: Inferred from direct assay	1652050	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	1315531	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HTR1B Protein Structure

7tm_1

0
100
200
300
390 a.a.

Protein Preferred Names

Protein Names

5-hydroxytryptamine receptor 1B

5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled

HTR1B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HTR1B	P28222	MDFI	Homo sapiens	Q99750	Y2H Array	25416956
Intra	HTR1B	P28222	MDFI	Homo sapiens	Q99750	Y2H Bait-Prey Pool	25910212
Intra	HTR1B	P28222	MDFI	Homo sapiens	Q99750	Validated Y2H	25910212
Intra	HTR1B	P28222	MDFI	Homo sapiens	Q99750	Y2H Array	24722188
Intra	HTR1B	P28222	MDFI	Homo sapiens	Q99750	Y2H Array	25910212
Intra	HTR1B	P28222	ACTN2	Homo sapiens	P35609	Validated Y2H	32296183
Intra	HTR1B	P28222	ACTN2	Homo sapiens	P35609	Y2H Array	32296183
Intra	HTR1B	P28222	ACTN2	Homo sapiens	P35609	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Obsessive-Compulsive Disorder

OCD	Obsessive-Compulsive Disorder, Susceptibility To
Anancastic Neurosis	Obsessive Compulsive Disorder
Anankastic Neurosis	Obsessive-Compulsive Neurosis
Obsessive Compulsive Behavior

Personality Disorder

Personality Disorders	Character Disorder
Personality	Specific Personality Disorders
Enduring Personality Change After Psychiatric Illness

Bulimia Nervosa

Bulimia	Bulimia Nervosa, Susceptibility To
Binge Eating Disorder	BULN
Bn	Hyperorexia Nervosa
Bulimia Nervosa 2	BULN2
Susceptibility To Bulimia Nervosa	Bulimia Nervosa, Susceptibility To, Type 2
Bn - [Bulimia Nervosa]	Bulimia Nos
Bulimic	Bingeing
Binge Overeating	Bouts Of Overeating
Episodes Of Overeating

Mood Disorder

Mood Disorders

Episodic Mood Disorder

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Migraine With Aura

Classic Migraine	Migraine With Typical Aura
Migraine Accompagnée	Complicated Migraine
Classical Migraine	Acute Migraine With Aura

Alcohol Dependence

Alcoholism	Alcohol Dependence, Susceptibility To
Alcohol Dependence, Protection Against	Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against
Alcoholism, Susceptibility To	Alcoholic Intoxication, Chronic
Pharyngeal Neoplasms	Chronic Alcoholism
Dipsomania	Alcohol Addiction
Ethanol Dependence	Chronic Ethanolism
Chronic Alcoholic Disease Nos	Alcoholic Disease Nos
Alcoholic

Borderline Personality Disorder

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Acute Frontal Sinusitis

Antisocial Personality Disorder

Dissocial Personality Disorder	Asocial Personality
Psychopath.Personality	Psychopathic Personality
Psychopathic Personality Disorder	Sociopathic Personality

Pulmonary Hypertension

Primary Pulmonary Hypertension	Hypertension Pulmonary
Hypertension, Pulmonary	Hypertension, Pulmonary, Primary
Idiopathic Pulmonary Hypertension	Idiopathic Pulmonary Arterial Hypertension
Pulmonary Htn - [Hypertension]

Panic Disorder

Panic Anxiety Syndrome	Panic
Panic Disorder 1	Episodic Paroxysmal Anxiety Disorder

Mesenteric Vascular Occlusion

Psychosexual Disorder

Psychosexual Disorders

Anxiety

Anxiety Disorder	Anxiety Disorders
Anxiety State	Anxieties
Anxiety Neurosis

Narcolepsy

Paroxysmal Sleep	Gelineau Syndrome
Narcoleptic Syndrome	Narcolepsy-Cataplexy Syndrome
Cataplexy And Narcolepsy	Narcolepsy, Without Cataplexy
Gelineau'S Syndrome	Narcolepsy With Or Without Cataplexy
Narcolepsy Nos

Amphetamine Abuse

Sexual Health Disorder

Sexual Health

Pyromania

Firesetting Behavior	Pathological Firesetting
Pathological Fire-Setting

Inhibited Male Orgasm

Male Orgasmic Disorder

Psychosexual Dysfunction With Male Orgasmic Disorder

Oppositional Defiant Disorder

Disorder	Oppositional Defiance
Behavioural Disorder	Oppositional Defiance
Disruptive Mood Dysregulation Disorder

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Mental Depression

Depression

Depressive Disorder

Generalized Anxiety Disorder

Anxiety Generalized

Motion Sickness

Airsickness	Carsickness
Seasickness	Travel Sickness
Riders' Vertigo

Vascular Disease

Vascular Diseases	Aneurysm
Spinal Cord Ischemia	Vascular Anomaly
Spinal Cord Vascular Diseases	Vascular Tissue Disease

Substance Dependence

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06461	HTR1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	HTR1B	VGNC	VGNC:73537
Rattus norvegicus	HTR1B	RGD	RGD:2846
Felis catus	HTR1B	VGNC	VGNC:67668
Mus musculus	HTR1B	MGD	MGI:96274
Bos taurus	HTR1B	VGNC	VGNC:29992