HTR1E - 5-hydroxytryptamine receptor 1E Gene

Homo sapiens

Also known as 5-HT1E

Gene ID: 3354 | Gene type: protein coding

About HTR1E

Cytogenetic location: 6q14.3 Genomic coordinates (GRCh38): 6:86,937,528-87,016,679 (from NCBI)

This gene has 1 transcript (splice variant), 158 orthologues and 8 paralogues. Biased expression in ovary (RPKM 1.3), endometrium (RPKM 0.7) and 4 other tissues.

Summary

Enables G protein-coupled serotonin receptor activity and serotonin binding activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

HTR1E Products(1)

mRNA	Protein	Name
NM_000865.3	NP_000856.1	5-hydroxytryptamine receptor 1E

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled serotonin receptor activity	IDA IDA: Inferred from direct assay	1608964	GOA
enables G protein-coupled serotonin receptor activity	IMP IMP: Inferred from mutant phenotype	21422162	GOA
enables Gi/o-coupled serotonin receptor activity	IDA IDA: Inferred from direct assay	33762731	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables serotonin binding	IDA IDA: Inferred from direct assay	1608964	GOA
enables serotonin receptor activity	IDA IDA: Inferred from direct assay	33762731	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21422162	GOA
involved in adenylate cyclase-inhibiting serotonin receptor signaling pathway	IDA IDA: Inferred from direct assay	33762731	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	21422162	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HTR1E Protein Structure

7tm_1

0
100
200
300
365 a.a.

Protein Preferred Names

Protein Names

5-hydroxytryptamine receptor 1E

5-HT-1E

HTR1E Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HTR1E	P28566	ATP5F1B	Homo sapiens	P06576	Anti Tag CoIP	33961781
Intra	HTR1E	P28566	ATP5F1B	Homo sapiens	P06576	Anti Tag CoIP	28514442
Intra	HTR1E	P28566	MEOX2	Homo sapiens	P50222	Y2H Array	25416956
Intra	HTR1E	P28566	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956
Intra	HTR1E	P28566	MEOX2	Homo sapiens	P50222	Validated Y2H	25416956
Intra	HTR1E	P28566	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053
Intra	HTR1E	P28566	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
Intra	HTR1E	P28566	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ocular Hypotension

Hypotony Of Eye

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06463	HTR1E Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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