UBAC2 - UBA domain containing 2 Gene

Homo sapiens

Also known as PHGDHL1

Gene ID: 337867 | Gene type: protein coding

About UBAC2

This gene has 11 transcripts (splice variants), 201 orthologues, 4 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 8.2), thyroid (RPKM 7.2) and 25 other tissues.

Summary

Involved in negative regulation of canonical Wnt signaling pathway and negative regulation of retrograde protein transport, ER to cytosol. Acts upstream of or within protein localization to endoplasmic reticulum. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

UBAC2 Products(2)

mRNA	Protein	Name
NM_001144072.2	NP_001137544.1	ubiquitin-associated domain-containing protein 2 isoform 1 precursor
NM_177967.4	NP_808882.1	ubiquitin-associated domain-containing protein 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22119785	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	31073040	GOA
involved in negative regulation of retrograde protein transport, ER to cytosol	IMP IMP: Inferred from mutant phenotype	25660456	GOA
acts upstream of or within protein localization to endoplasmic reticulum	IDA IDA: Inferred from direct assay	23297223	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	23297223	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBAC2 Protein Structure

UBA

0
100
200
300
344 a.a.

Protein Preferred Names

Protein Names

ubiquitin-associated domain-containing protein 2

RP11-178C10.1

Related Diseases

Diseases

Alias

Behcet Syndrome

Behcet Disease	Behcet'S Syndrome
Behcet'S Disease	Behçet Disease
Bd	Adamantiades-Behcet Disease
Triple Symptom Complex	Behçet'S Disease
Behet'S Syndrome	Bd Syndrome
Behçet Syndrome	Behçet'S Syndrome
Behcet Triple Symptom Complex	Malignant Aphthosis
Old Silk Route Disease	Adamantiades-Behçet Disease

Hypopyon

Photoallergic Dermatitis

Dermatitis, Photoallergic	Photoallergic Contact Dermatitis
Photoallergic Eczema	Photo-Allergic Contact Eczema

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15327	UBAC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	UBAC2	VGNC	VGNC:102355
Rattus norvegicus	UBAC2	RGD	RGD:1311689
Macaca mulatta	UBAC2	VGNC	VGNC:106308
Bos taurus	UBAC2	VGNC	VGNC:36568
Canis familiaris	UBAC2	VGNC	VGNC:48043
Mus musculus	UBAC2	MGD	MGI:1916139

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