ID3 - inhibitor of DNA binding 3 Gene

Homo sapiens

Also known as HEIR-1; bHLHb25

Gene ID: 3399 | Gene type: protein coding

About ID3

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:23,557,926-23,559,501 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 199 orthologues, 3 paralogues and is associated with 33 phenotypes. Broad expression in thyroid (RPKM 81.9), prostate (RPKM 51.6) and 21 other tissues.

Summary

The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with Other HLH proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any HLH protein with which it interacts. [provided by RefSeq, Aug 2011]

ID3 Products(1)

mRNA	Protein	Name
NM_002167.5	NP_002158.3	DNA-binding protein inhibitor ID-3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18255255	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	14627819	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14627819	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ID3 Protein Structure

HLH

0
100
119 a.a.

Protein Preferred Names

Protein Names

DNA-binding protein inhibitor ID-3

ID-like protein inhibitor HLH 1R21

ID3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ID3	Q02535	CREB5	Homo sapiens	Q02930-3	Validated Y2H	32296183
Intra	ID3	Q02535	FAM74A1	Homo sapiens	Q5RGS3	Y2H Prey Pooling	25416956
Intra	ID3	Q02535	FAM74A1	Homo sapiens	Q5RGS3	Validated Y2H	25416956
Intra	ID3	Q02535	FAM74A1	Homo sapiens	Q5RGS3	Y2H Array	25416956
Intra	ID3	Q02535	RAB7A	Homo sapiens	P51149	Y2H Array	32814053
Intra	ID3	Q02535	RAB7A	Homo sapiens	P51149	Y2H Pooling	32814053
Intra	ID3	Q02535	RAB7A	Homo sapiens	P51149	Validated Y2H	32814053
Intra	ID3	Q02535	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	ID3	Q02535	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	ID3	Q02535	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	ID3	Q02535	TCF12	Homo sapiens	Q99081-3	Validated Y2H	32296183
Intra	ID3	Q02535	TCF12	Homo sapiens	Q99081-3	Y2H Array	32296183
Intra	ID3	Q02535	TCF12	Homo sapiens	Q99081-3	Y2H Array	31515488
Intra	ID3	Q02535	TCF12	Homo sapiens	Q99081-3	Y2H Prey Pooling	32296183
Intra	ID3	Q02535	ANKS1A	Homo sapiens	Q49AR9	Validated Y2H	32296183
Intra	ID3	Q02535	GUCD1	Homo sapiens	Q96NT3-2	Validated Y2H	32296183
Intra	ID3	Q02535	TCF3	Homo sapiens	P15923-3	Y2H Prey Pooling	32296183
Intra	ID3	Q02535	TCF3	Homo sapiens	P15923-3	Y2H Array	32296183
Intra	ID3	Q02535	TCF4	Homo sapiens	P15884-3	Y2H Array	32296183
Intra	ID3	Q02535	TCF4	Homo sapiens	P15884-3	Y2H Prey Pooling	32296183
Intra	ID3	Q02535	MYF5	Homo sapiens	P13349	Y2H Prey Pooling	32296183
Intra	ID3	Q02535	MYF5	Homo sapiens	P13349	Y2H Array	32296183
Intra	ID3	Q02535	KRTAP26-1	Homo sapiens	Q6PEX3	Validated Y2H	32296183
Intra	ID3	Q02535	KAT5	Homo sapiens	Q92993	Validated Y2H	32296183
Intra	ID3	Q02535	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	ID3	Q02535	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	ID3	Q02535	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	ID3	Q02535	TCF4	Homo sapiens	P15884	Validated Y2H	25416956
Intra	ID3	Q02535	FHL2	Homo sapiens	Q14192	Y2H	18255255
Intra	ID3	Q02535	FHL2	Homo sapiens	Q14192	Validated Y2H	32296183
Intra	ID3	Q02535	TCF12	Homo sapiens	Q99081	Y2H Array	31515488
Intra	ID3	Q02535	TCF12	Homo sapiens	Q99081	Validated Y2H	25416956
Intra	ID3	Q02535	TCF12	Homo sapiens	Q99081	Y2H Prey Pooling	25416956
Intra	ID3	Q02535	TCF12	Homo sapiens	Q99081	Y2H Array	20211142
Intra	ID3	Q02535	C22orf39	Homo sapiens	Q6P5X5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Burkitt Lymphoma

Burkitt'S Lymphoma	BL
Burkitt Lymphoma, Somatic	Burkitt Lymphoma/Leukaemia
Burkitt'S Tumor	Burkitt'S Tumor Or Lymphoma
Malignant Lymphoma, Burkitt'S Type	Small Non-Cleaved Cell Lymphoma, Burkitt'S Type
Small Non-Cleaved Cell Lymphoma	Burkitt Tumor
Burkitts Lymphoma	Lymphoma, Small Noncleaved-Cell
Burkitt Tumour	Diffuse Small Noncleaved Malignant Burkitt Lymphoma
Malignant Burkitt Lymphoma	“Burkitt-Like” Lymphoma
Undifferentiated Burkitt Lymphoma	Small Noncleaved Cell Burkitt Lymphoma

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124697	BMP signaling agonist sb4	Agonist	99.98%	Unkown
HY-110245	DMH2	Inducer	99.6%	Unkown
HY-143623S	Neo Spiramycin I-d3		/	Unkown
HY-155705	BMP agonist 1		/	Unkown
HY-RS06524	ID3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ID3	VGNC	VGNC:41862
Bos taurus	ID3	VGNC	VGNC:30032
Macaca mulatta	ID3	VGNC	VGNC:99974
Rattus norvegicus	ID3	RGD	RGD:2860
Felis catus	ID3	VGNC	VGNC:107562
Mus musculus	ID3	MGD	MGI:96398
Others	ID3	NCBI

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