2. Gene
  3. ID3 - inhibitor of DNA binding 3 Gene

ID3 - inhibitor of DNA binding 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HEIR-1; bHLHb25

Gene ID: 3399 | Gene type: protein coding

About ID3

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:23,557,926-23,559,501 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 199 orthologues, 3 paralogues and is associated with 33 phenotypes. Broad expression in thyroid (RPKM 81.9), prostate (RPKM 51.6) and 21 other tissues.

Summary

The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any HLH protein with which it interacts. [provided by RefSeq, Aug 2011]

ID3 Products(1)

mRNA Protein Name
NM_002167.5 NP_002158.3 DNA-binding protein inhibitor ID-3
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
18255255 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
14627819 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
14627819 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ID3 Protein Structure

HLH

HLH: Helix-loop-helix DNA-binding domain (42 - 81)

  • 0
  • 100
  • 119 a.a.
Protein Preferred Names Protein Names

DNA-binding protein inhibitor ID-3

ID-like protein inhibitor HLH 1R21

ID3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra ID3 Q02535 CREB5 Homo sapiens Q02930-3
Validated Y2H
32296183
Intra ID3 Q02535 FAM74A1 Homo sapiens Q5RGS3
Y2H Prey Pooling
25416956
Intra ID3 Q02535 FAM74A1 Homo sapiens Q5RGS3
Validated Y2H
25416956
Intra ID3 Q02535 FAM74A1 Homo sapiens Q5RGS3
Y2H Array
25416956
Intra ID3 Q02535 RAB7A Homo sapiens P51149
Y2H Array
32814053
Intra ID3 Q02535 RAB7A Homo sapiens P51149
Y2H Pooling
32814053
Intra ID3 Q02535 RAB7A Homo sapiens P51149
Validated Y2H
32814053
Intra ID3 Q02535 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
Intra ID3 Q02535 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
Intra ID3 Q02535 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
Intra ID3 Q02535 TCF12 Homo sapiens Q99081-3
Validated Y2H
32296183
Intra ID3 Q02535 TCF12 Homo sapiens Q99081-3
Y2H Array
32296183
Intra ID3 Q02535 TCF12 Homo sapiens Q99081-3
Y2H Array
31515488
Intra ID3 Q02535 TCF12 Homo sapiens Q99081-3
Y2H Prey Pooling
32296183
Intra ID3 Q02535 ANKS1A Homo sapiens Q49AR9
Validated Y2H
32296183
Intra ID3 Q02535 GUCD1 Homo sapiens Q96NT3-2
Validated Y2H
32296183
Intra ID3 Q02535 TCF3 Homo sapiens P15923-3
Y2H Prey Pooling
32296183
Intra ID3 Q02535 TCF3 Homo sapiens P15923-3
Y2H Array
32296183
Intra ID3 Q02535 TCF4 Homo sapiens P15884-3
Y2H Array
32296183
Intra ID3 Q02535 TCF4 Homo sapiens P15884-3
Y2H Prey Pooling
32296183
Intra ID3 Q02535 MYF5 Homo sapiens P13349
Y2H Prey Pooling
32296183
Intra ID3 Q02535 MYF5 Homo sapiens P13349
Y2H Array
32296183
Intra ID3 Q02535 KRTAP26-1 Homo sapiens Q6PEX3
Validated Y2H
32296183
Intra ID3 Q02535 KAT5 Homo sapiens Q92993
Validated Y2H
32296183
Intra ID3 Q02535 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra ID3 Q02535 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra ID3 Q02535 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra ID3 Q02535 TCF4 Homo sapiens P15884
Validated Y2H
25416956
Intra ID3 Q02535 FHL2 Homo sapiens Q14192
Y2H
18255255
Intra ID3 Q02535 FHL2 Homo sapiens Q14192
Validated Y2H
32296183
Intra ID3 Q02535 TCF12 Homo sapiens Q99081
Y2H Array
31515488
Intra ID3 Q02535 TCF12 Homo sapiens Q99081
Validated Y2H
25416956
Intra ID3 Q02535 TCF12 Homo sapiens Q99081
Y2H Prey Pooling
25416956
Intra ID3 Q02535 TCF12 Homo sapiens Q99081
Y2H Array
20211142
Intra ID3 Q02535 C22orf39 Homo sapiens Q6P5X5
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Burkitt Lymphoma

Burkitt'S Lymphoma

BL

Burkitt Lymphoma, Somatic

Burkitt Lymphoma/Leukaemia

Burkitt'S Tumor

Burkitt'S Tumor Or Lymphoma

Malignant Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma

Burkitt Tumor

Burkitts Lymphoma

Lymphoma, Small Noncleaved-Cell

Burkitt Tumour

Diffuse Small Noncleaved Malignant Burkitt Lymphoma

Malignant Burkitt Lymphoma

“Burkitt-Like” Lymphoma

Undifferentiated Burkitt Lymphoma

Small Noncleaved Cell Burkitt Lymphoma
T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia

Acute T Cell Leukemia

Precursor T Lymphoblastic Leukemia

Precursor T-Lymphoblastic Lymphoma/Leukemia

T Acute Lymphoblastic Leukemia

T-Cell Acute Lymphocytic Leukaemia

T-Cell Lymphoblastic Leukemia/Lymphoma

Leukemia T-Cell

Leukemia, T-Cell

Leukemia, Acute, Lymphoblastic, T-Cell

Leukemia, T-Cell Acute Lymphoblastic

Leukemia, Acute T-Cell

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Precursor T-Cell Lymphoblastic Lymphoma

Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-124697 BMP signaling agonist sb4 Agonist 99.98% Unkown
HY-110245 DMH2 Inducer 99.6% Unkown
HY-143623S Neo Spiramycin I-d3 / Unkown
HY-155705 BMP agonist 1 / Unkown
HY-RS06524 ID3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ID3 VGNC VGNC:41862
Bos taurus ID3 VGNC VGNC:30032
Macaca mulatta ID3 VGNC VGNC:99974
Rattus norvegicus ID3 RGD RGD:2860
Felis catus ID3 VGNC VGNC:107562
Mus musculus ID3 MGD MGI:96398
Others ID3 NCBI