CD300E - CD300e molecule Gene

Homo sapiens

Also known as CLM2; CLM-2; IREM2; PIgR2; IREM-2; PIgR-2; CD300LE; CMRF35-A5

Gene ID: 342510 | Gene type: protein coding

About CD300E

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:74,609,885-74,623,738 (from NCBI)

This gene has 2 transcripts (splice variants), 66 orthologues and 13 paralogues. Biased expression in appendix (RPKM 19.2), bone marrow (RPKM 15.3) and 4 other tissues.

Summary

This gene encodes a member of the CD300 glycoprotein family of cell surface proteins expressed on myeloid cells. The protein interacts with the TYRO protein tyrosine kinase-binding protein and is thought to act as an activating receptor. [provided by RefSeq, Nov 2012]

CD300E Products(1)

mRNA	Protein	Name
NM_181449.3	NP_852114.2	CMRF35-like molecule 2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20959446	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD300E Protein Structure

V-set

0
100
200
232 a.a.

Protein Preferred Names

Protein Names

CMRF35-like molecule 2

CD300 antigen-like family member E

CD300E Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CD300E	Q496F6	CTXN3	Homo sapiens	Q4LDR2	Validated Y2H	32296183
Intra	CD300E	Q496F6	STX8	Homo sapiens	Q9UNK0	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD300E Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76223	CD300e Protein, Human (HEK293, Fc)	Q496F6 (L18-H173)	≥95%

Related Diseases

Diseases

Alias

Tungiasis

Tunga Penetrans Infestation	Chigger Flea
S Penetrans	Sarcopsylla Penetrans
T Penetrans	Tunga Penetrans
Sand-Flea Infestation	Jiggers Infestation
Chigoe Infestation	Jigger Disease

Amelogenesis Imperfecta, Type Ia

Amelogenesis Imperfecta Type 1a	AI1A
Amelogenesis Imperfecta, Hypoplastic Type Ia	Amelogenesis Imperfecta Type Ia
Amelogenesis Imperfecta Hypoplastic Type Ia	Amelogenesis Imperfecta 1a

Myeloid Leukemia Associated With Down Syndrome

Lice Infestation

Pediculosis	Louse Infestation
Mixed Pediculosis	Lice Infestations
Infestation By Pediculus	Mixed Pediculosis Infestation
Pediculosis + Lice	Pediculosis And Phthirus Infection
Pediculosis And Phthirus Infections	Pediculosis And Phthirus Infestation
Infestation By Anoplura	Pediculus Infestation
Lice Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02228	CD300E Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CD300E	VGNC	VGNC:38947
Mus musculus	CD300E	MGD	MGI:2387602
Macaca mulatta	CD300E	VGNC	VGNC:84878
Bos taurus	CD300E	VGNC	VGNC:57137
Rattus norvegicus	CD300E	RGD	RGD:1585137
Others	CD300E	NCBI

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