SH3RF3 - SH3 domain containing ring finger 3 Gene

Homo sapiens

Also known as POSH2; SH3MD4

Gene ID: 344558 | Gene type: protein coding

About SH3RF3

Cytogenetic location: 2q13 Genomic coordinates (GRCh38): 2:109,129,205-109,504,634 (from NCBI)

This gene has 1 transcript (splice variant), 189 orthologues and 12 paralogues. Ubiquitous expression in testis (RPKM 1.9), gall bladder (RPKM 1.8) and 25 other tissues.

Summary

Enables ubiquitin protein Ligase activity. Involved in positive regulation of JNK cascade and protein autoubiquitination. [provided by Alliance of Genome Resources, Apr 2022]

SH3RF3 Products(1)

mRNA	Protein	Name
NM_001099289.3	NP_001092759.1	E3 ubiquitin-protein ligase SH3RF3 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16374509	GOA
enables ubiquitin protein ligase activity	IMP IMP: Inferred from mutant phenotype	20696164	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	20696164	GOA
involved in protein autoubiquitination	IMP IMP: Inferred from mutant phenotype	20696164	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SH3RF3 Protein Structure

zf-C3HC4

SH3_9

0
200
400
600
800
882 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase SH3RF3

SH3 domain-containing RING finger protein 3

SH3RF3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SH3RF3	Q8TEJ3	PAK2	Homo sapiens	Q13177	Phage Display	16374509
Intra	SH3RF3	Q8TEJ3	PAK2	Homo sapiens	Q13177	Filter Binding	16374509
Intra	SH3RF3	Q8TEJ3	RAC1	Homo sapiens	P63000	Solid Phase Assay	20696164
Intra	SH3RF3	Q8TEJ3	RAC1	Homo sapiens	P63000	Anti Tag CoIP	20696164

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 17

RP17	Retinitis Pigmentosa-17
Retinitis Pigmentosa, Type 17

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12846	SH3RF3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SH3RF3	VGNC	VGNC:46134
Macaca mulatta	SH3RF3	VGNC	VGNC:77302
Felis catus	SH3RF3	VGNC	VGNC:65115
Rattus norvegicus	SH3RF3	RGD	RGD:1589772
Bos taurus	SH3RF3	VGNC	VGNC:34581
Mus musculus	SH3RF3	MGD	MGI:2444637
Others	SH3RF3	NCBI

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