IRGM - immunity related GTPase M Gene

Homo sapiens

Also known as IFI1; IRGM1; LRG47; LRG-47

Gene ID: 345611 | Gene type: protein coding

About IRGM

Cytogenetic location: 5q33.1 Genomic coordinates (GRCh38): 5:150,846,521-150,902,402 (from NCBI)

This gene has 3 transcripts (splice variants), 360 orthologues, 1 paralogue and is associated with 3 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating Autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016]

IRGM Products(2)

mRNA	Protein	Name
NM_001145805.2	NP_001139277.1	immunity-related GTPase family M protein isoform 2
NM_001346557.2	NP_001333486.1	immunity-related GTPase family M protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables BH3 domain binding	IMP IMP: Inferred from mutant phenotype	25891078	GOA
enables CARD domain binding	IMP IMP: Inferred from mutant phenotype	25891078	GOA
enables G protein activity	IDA IDA: Inferred from direct assay	30612879	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	29420192	GOA
enables cardiolipin binding	IDA IDA: Inferred from direct assay	21102437	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25891078	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	25891078	GOA
enables protein serine/threonine kinase activator activity	IDA IDA: Inferred from direct assay	25891078	GOA
enables protein serine/threonine kinase activator activity	IMP IMP: Inferred from mutant phenotype	28389568	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	25891078	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in CAMKK-AMPK signaling cascade	IMP IMP: Inferred from mutant phenotype	25891078	GOA
involved in autophagosome assembly	IMP IMP: Inferred from mutant phenotype	16888103	GOA
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	25891078	GOA
involved in cellular response to virus	IMP IMP: Inferred from mutant phenotype	28389568	GOA
involved in defense response to Gram-negative bacterium	IMP IMP: Inferred from mutant phenotype	25891078	GOA
involved in defense response to bacterium	IDA IDA: Inferred from direct assay	25891078	GOA
involved in defense response to bacterium	IMP IMP: Inferred from mutant phenotype	16888103	GOA
involved in innate immune response	IMP IMP: Inferred from mutant phenotype	16888103	GOA
involved in negative regulation of NLRP3 inflammasome complex assembly	IDA IDA: Inferred from direct assay	30612879	GOA
involved in negative regulation of cGAS/STING signaling pathway	IDA IDA: Inferred from direct assay	32715615	GOA
involved in negative regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	36221902	GOA
involved in negative regulation of defense response to virus	IDA IDA: Inferred from direct assay	34467632	GOA
involved in negative regulation of inflammatory response	IDA IDA: Inferred from direct assay	30612879	GOA
involved in negative regulation of type I interferon production	IDA IDA: Inferred from direct assay	32715615	GOA
involved in nucleotide-binding oligomerization domain containing 2 signaling pathway	IMP IMP: Inferred from mutant phenotype	25891078	GOA
involved in positive regulation of autophagosome maturation	IMP IMP: Inferred from mutant phenotype	16888103	GOA
involved in positive regulation of autophagy	IDA IDA: Inferred from direct assay	25891078	GOA
involved in positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	16888103	GOA
involved in positive regulation of lysosome organization	IDA IDA: Inferred from direct assay	32753672	GOA
involved in positive regulation of mitochondrial fission	IDA IDA: Inferred from direct assay	21102437	GOA
involved in positive regulation of mitophagy	IDA IDA: Inferred from direct assay	21102437	GOA
involved in positive regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	25891078	GOA
involved in positive regulation of peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	25891078	GOA
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	28389568	GOA
involved in positive regulation of protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	28389568	GOA
involved in positive regulation of type II interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	16888103	GOA
involved in positive regulation of xenophagy	IDA IDA: Inferred from direct assay	25891078	GOA
involved in protein destabilization	IMP IMP: Inferred from mutant phenotype	25891078	GOA
involved in protein lipidation involved in autophagosome assembly	IMP IMP: Inferred from mutant phenotype	28389568	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	25891078	GOA
involved in protein targeting to vacuole involved in autophagy	IDA IDA: Inferred from direct assay	29420192	GOA
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	25891078	GOA
involved in regulation of protein complex stability	IMP IMP: Inferred from mutant phenotype	25891078	GOA
involved in regulation of protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	25891078	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	28389568	GOA
located in Golgi membrane	IDA IDA: Inferred from direct assay	28389568	GOA
is active in autophagosome membrane	IDA IDA: Inferred from direct assay	30612879	GOA
located in cytosol	IDA IDA: Inferred from direct assay	25891078	GOA
is active in mitochondrion	IDA IDA: Inferred from direct assay	21102437	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	25891078	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IRGM Protein Structure

IIGP

0
100
181 a.a.

Protein Preferred Names

Protein Names

immunity-related GTPase family M protein

LPS-stimulated RAW 264.7 macrophage protein 47 homolog

IRGM Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	IRGM	A1A4Y4	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	IRGM	A1A4Y4	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053
Intra	IRGM	A1A4Y4	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Inflammatory Bowel Disease 19

Inflammatory Bowel Disease 19	IBD19
Bowel Disease, Inflammatory, Type 19

Crohn'S Disease

Crohn Disease	Pediatric Crohn'S Disease
Regional Enteritis	Crohn'S Disease Of Large Bowel
Granulomatous Colitis	Enteritis, Granulomatous
Enteritis	Crohn'S Disease Of Colon
Colitis, Granulomatous	Crohn'S Enteritis
Enteritis, Regional	Ileitis
Adenoviral Enteritis	Acute Gastroenteropathy Due To Norwalk Agent
Viral Gastroenteritis Due To Norwalk Agent	Winter Vomiting
Epidemic Winter Vomiting Disease	Small Round Structured Virus Enteritis
Epidemic Vomiting Syndrome	Epidemic Vomiting
Epidemic Nausea	Epidemic Viral Gastroenteritis Due To Norwalk Virus
Noroviral Enteritis	Crohn Disease Nos
Crohns	Cd - [Crohn'S Disease]
Regional Enteritis Of Bowel	Crohn'S Regional Enteritis
Cobble-Stone Appearance Of Intestine	Intestinal Ulcer And Erosion Due To Crohn Disease
Granulomatous Enteritis

Colitis

Ulcerative Colitis

Colitis Gravis	Left Sided Ulcerative Colitis
Left-Sided Ulcerative Colitis	Idiopathic Proctocolitis
Inflammatory Bowel Disease, Ulcerative Colitis Type	Uc
Colitis Ulcerative	Colitis, Ulcerative
Chronic Left-Sided Ulcerative Colitis	Uc - [Ulcerative Colitis]
Chronic Ulcerative Enteritis	Mucosal Proctocolitis
Ulcerative Mucosal Proctocolitis	Left Hemicolitis

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Inflammatory Bowel Disease 5

IBD5

Inflammatory Bowel Disease 1

Inflammatory Bowel Disease 1	IBD1
Crohn Disease-Associated Growth Failure	Crohn Disease
Regional Enteritis	Ulcerative Colitis
Crohn Disease-Associated Growth Failure, Susceptibility To	Inflammatory Bowel Disease 1, Crohn Disease
Bowel Disease, Inflammatory, Type 1

Crohn'S Colitis

Crohn Disease

Ileitis

Crohn'S Ileitis

Autoimmune Disease Of Gastrointestinal Tract

Leprosy 3

Leprosy	Leprosy, Susceptibility To, 3
Hansen'S Disease	Leprosy, Susceptibility To
Hansen Disease	Infection Due To Mycobacterium Leprae
LPRS3	Leprosy, Type 3
Anaesthesia Leprosy	Anaesthetic Leprosy
Maculoanaesthetic Leprosy	Macular Leprosy
Leprosy Unspecified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06915	IRGM Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	IRGM	RGD	RGD:1305163

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