1. Gene
  2. IGFBP6 - insulin like growth factor binding protein 6 Gene

IGFBP6 - insulin like growth factor binding protein 6 Gene

Homo sapiens

Also known as IBP6

Gene ID: 3489 | Gene type: protein coding

About IGFBP6

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:53,097,667-53,102,340 (from NCBI)

This gene has 5 transcripts (splice variants), 242 orthologues and 5 paralogues. Broad expression in fat (RPKM 60.7), prostate (RPKM 49.9) and 17 other tissues.

Summary

Enables identical protein binding activity and insulin-like growth factor II binding activity. Involved in cell migration and positive regulation of stress-activated MAPK cascade. Part of insulin-like growth factor binary complex. Implicated in obesity. Biomarker of breast cancer; in situ carcinoma; leiomyoma; and neovascular inflammatory vitreoretinopathy. [provided by Alliance of Genome Resources, Apr 2022]

IGFBP6 Products(1)

mRNA Protein Name
NM_002178.3 NP_002169.1 insulin-like growth factor-binding protein 6 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables insulin-like growth factor II binding IMP
IMP: Inferred from mutant phenotype
15308688 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24003225 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cell migration IDA
IDA: Inferred from direct assay
24003225 GOA
involved in positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
24003225 GOA
involved in positive regulation of stress-activated MAPK cascade IDA
IDA: Inferred from direct assay
24003225 GOA
Cellular Component GO Annotation Evidence Reference Source
part of insulin-like growth factor binary complex IMP
IMP: Inferred from mutant phenotype
15308688 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IGFBP6 Protein Structure

IGFBP

IGFBP: Insulin-like growth factor binding protein (29 - 84)

Thyroglobulin_1

Thyroglobulin_1: Thyroglobulin type-1 repeat (163 - 234)

  • 0
  • 100
  • 200
  • 240 a.a.
Protein Preferred Names Protein Names

insulin-like growth factor-binding protein 6

IBP-6

IGFBP6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
IGFBP6 P24592 KRTAP10-8 Homo sapiens P60410
Validated Y2H
32296183
Intra
IGFBP6 P24592 CREB5 Homo sapiens Q02930-3
Validated Y2H
32296183
Intra
IGFBP6 P24592 CCDC28A Homo sapiens Q7Z6N9
Validated Y2H
32296183
Intra
IGFBP6 P24592 KRTAP5-7 Homo sapiens Q6L8G8
Validated Y2H
32296183
Intra
IGFBP6 P24592 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Array
32296183
Intra
IGFBP6 P24592 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Prey Pooling
32296183
Intra
IGFBP6 P24592 C1orf74 Homo sapiens Q96LT6
Validated Y2H
32296183
Intra
IGFBP6 P24592 PLEKHA7 Homo sapiens Q6IQ23-2
Validated Y2H
32296183
Intra
IGFBP6 P24592 ANKRD11 Homo sapiens X5D778
Validated Y2H
32296183
Intra
IGFBP6 P24592 POU4F2 Homo sapiens Q12837
Validated Y2H
32296183
Intra
IGFBP6 P24592 RANBP10 Homo sapiens Q6VN20
Validated Y2H
32296183
Intra
IGFBP6 P24592 SGTA Homo sapiens O43765
Y2H Array
32296183
Intra
IGFBP6 P24592 SGTA Homo sapiens O43765
Y2H Prey Pooling
32296183
Intra
IGFBP6 P24592 KRTAP5-9 Homo sapiens P26371
Y2H Array
32296183
Intra
IGFBP6 P24592 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
32296183
Intra
IGFBP6 P24592 KRTAP5-9 Homo sapiens P26371
Validated Y2H
32296183
Intra
IGFBP6 P24592 RABGGTB Homo sapiens P53611
Validated Y2H
32296183
Intra
IGFBP6 P24592 RABGGTB Homo sapiens P53611
Y2H Array
32296183
Intra
IGFBP6 P24592 RABGGTB Homo sapiens P53611
Y2H Prey Pooling
32296183
Intra
IGFBP6 P24592 EFEMP1 Homo sapiens Q12805
Validated Y2H
32296183
Intra
IGFBP6 P24592 ZNF587 Homo sapiens Q96SQ5
Validated Y2H
32296183
Intra
IGFBP6 P24592 ZNF417 Homo sapiens Q8TAU3
Validated Y2H
32296183
Intra
IGFBP6 P24592 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
Intra
IGFBP6 P24592 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra
IGFBP6 P24592 CCDC116 Homo sapiens Q8IYX3
Validated Y2H
32296183
Intra
IGFBP6 P24592 AQP1 Homo sapiens P29972
Validated Y2H
32296183
Intra
IGFBP6 P24592 UBAC1 Homo sapiens Q9BSL1
Validated Y2H
32296183
Intra
IGFBP6 P24592 NCALD Homo sapiens P61601
Validated Y2H
32296183
Intra
IGFBP6 P24592 SMCP Homo sapiens P49901
Y2H Array
32296183
Intra
IGFBP6 P24592 SMCP Homo sapiens P49901
Validated Y2H
32296183
Intra
IGFBP6 P24592 SMCP Homo sapiens P49901
Y2H Prey Pooling
32296183
Intra
IGFBP6 P24592 EPDR1 Homo sapiens Q9UM22
Validated Y2H
32296183
Intra
IGFBP6 P24592 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra
IGFBP6 P24592 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
IGFBP6 P24592 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IGFBP6 Proteins

Cat. No. Product Name Accession Purity
HY-P73141 IGFBP-6 Protein, Human (HEK293, His) P24592 (R28-G240) ≥95%

Related Diseases

Diseases Alias
In Situ Carcinoma

Carcinoma In Situ

Insulin-Like Growth Factor I

Insulin-Like Growth Factor I Deficiency

IGF1 DEFICIENCY

Insulin-Like Growth Factor I, Resistance To

Growth Retardation With Deafness And Mental Retardation Due To Igf1 Deficiency

Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency

Growth Delay Due To Insulin-Like Growth Factor I Resistance

IGF1RES

Igf-I Resistance

Somatomedin, End-Organ Insensitivity To

Somatomedin-C

Somatomedin-C, Resistance To

Growth Retardation With Sensorineural Deafness And Mental Retardation

Insulin-Like Growth Factor 1 Resistance To

Igf-1 Resistance

Somatomedin End-Organ Insensitivity To

Somatomedin-C Resistance To

Growth Restriction With Sensorineural Deafness And Intellectual Disability

Growth Delay-Deafness-Intellectual Disability Syndrome

Growth Delay-Hearing Loss-Intellectual Disability Syndrome

Igf-1 Deficiency

Primary Insulin-Like Growth Factor Deficiency

Resistance To Igf-1

Insulin-Like Growth Factor 1 Resistance

End-Organ Insensitivity To Somatomedin

Igf1 Resistance

Resistance To Insulin-Like Growth Factor I

Resistance To Somatomedin-C

Insulin-Like Growth Factor 1, Resistance To

Acth-Secreting Pituitary Adenoma

Acth-Producing Pituitary Adenoma

Corticotroph Adenoma

Corticotropinoma

Pituitary-Dependent Cushing'S Disease

Adrenal Gland Hyperfunction

Cushing Syndrome

Vitreoretinopathy
Rhabdomyosarcoma
Sotos Syndrome

Cerebral Gigantism

SOTOS

Chromosome 5q35 Deletion Syndrome

Sotos Syndrome 1, Formerly

Sotos1, Formerly

Distinctive Facial Appearance, Overgrowth In Childhood, And Learning Disabilities Or Delayed Development

Sotos Sequence

Sotos' Syndrome

Sotos1

Sotos Syndrome 1

Renal Osteodystrophy

Renal Rickets

Chronic Kidney Disease-Mineral And Bone Disorder

Osteogenic Sarcoma

Osteosarcoma

OSRC

Osteosarcoma, Somatic

Neoplasms, Bone Tissue

Bone Tissue Neoplasm

Osteoid Sarcoma

Skeletal Sarcoma

Osteosarcoma Of Bone

Bone Sarcoma

Middle Cerebral Artery Infarction

Infarction, Middle Cerebral Artery

Infarction Middle Cerebral Artery

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Pheochromocytoma

Pheochromocytoma, Susceptibility To

Phaeochromocytoma

Adrenal Gland Chromaffin Paraganglioma

Adrenal Gland Chromaffinoma

Adrenal Gland Paraganglioma

Adrenal Gland Pheochromocytoma

Chromaffin Paraganglioma Of The Adrenal Gland

Intraadrenal Paraganglioma

PCC

Chromaffin Cell Tumor

Medullary Chromaffinoma

Medullary Paraganglioma

Pheochromoblastoma

Pheochromocytomas

Chromaffin Cell Neoplasm

Pheochromocytoma, Malignant

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta IGFBP6 VGNC VGNC:108351
Canis familiaris IGFBP6 VGNC VGNC:41907
Mus musculus IGFBP6 MGD MGI:96441
Bos taurus IGFBP6 VGNC VGNC:30088
Felis catus IGFBP6 VGNC VGNC:67716
Rattus norvegicus IGFBP6 RGD RGD:2877
Others IGFBP6 NCBI