GPR141 - G protein-coupled receptor 141 Gene

Homo sapiens

Also known as PGR13

Gene ID: 353345 | Gene type: protein coding

About GPR141

Cytogenetic location: 7p14.1 Genomic coordinates (GRCh38): 7:37,683,766-37,743,835 (from NCBI)

This gene has 5 transcripts (splice variants), 195 orthologues and 7 paralogues. Biased expression in bone marrow (RPKM 2.2), appendix (RPKM 0.5) and 10 other tissues.

Summary

GPR141 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]

GPR141 Products(4)

mRNA	Protein	Name
NM_001329993.2	NP_001316922.1	probable G-protein coupled receptor 141
NM_001329994.2	NP_001316923.1	probable G-protein coupled receptor 141
NM_001381946.1	NP_001368875.1	probable G-protein coupled receptor 141
NM_181791.3	NP_861456.1	probable G-protein coupled receptor 141

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR141 Protein Structure

7tm_1

0
100
200
305 a.a.

Protein Preferred Names

Protein Names

probable G-protein coupled receptor 141

G-protein coupled receptor PGR13

GPR141 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GPR141	Q7Z602	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	GPR141	Q7Z602	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	GPR141	Q7Z602	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	GPR141	Q7Z602	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	GPR141	Q7Z602	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	GPR141	Q7Z602	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	GPR141	Q7Z602	CTSD	Homo sapiens	P07339	Y2H Array	32814053
Intra	GPR141	Q7Z602	CTSD	Homo sapiens	P07339	Y2H Pooling	32814053
Intra	GPR141	Q7Z602	CTSD	Homo sapiens	P07339	Validated Y2H	32814053
Intra	GPR141	Q7Z602	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	GPR141	Q7Z602	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	GPR141	Q7Z602	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	GPR141	Q7Z602	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	GPR141	Q7Z602	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	GPR141	Q7Z602	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	GPR141	Q7Z602	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	GPR141	Q7Z602	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	GPR141	Q7Z602	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	GPR141	Q7Z602	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	GPR141	Q7Z602	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	GPR141	Q7Z602	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	GPR141	Q7Z602	TTR	Homo sapiens	P02766	Validated Y2H	32814053
Intra	GPR141	Q7Z602	TTR	Homo sapiens	P02766	Y2H Array	32814053
Intra	GPR141	Q7Z602	TTR	Homo sapiens	P02766	Y2H Pooling	32814053
Intra	GPR141	Q7Z602	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	GPR141	Q7Z602	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	GPR141	Q7Z602	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Diamond-Blackfan Anemia 4

DBA4	Rps17-Related Diamond-Blackfan Anemia
Anemia, Diamond-Blackfan, Type 4

Townes-Brocks Syndrome

Townes Syndrome	Renal-Ear-Anal-Radial Syndrome
Anus, Imperforate, With Hand, Foot And Ear Anomalies	Imperforate Anus-Hand, Foot And Ear Anomalies Syndrome
Rear Syndrome	Sensorineural Deafness With Imperforate Anus And Hypoplastic Thumbs
Tbs	Deafness, Sensorineural, With Imperforate Anus And Hypoplastic Thumbs
Imperforate Anus With Hand, Foot And Ear Anomalies	Anal-Ear-Renal-Radial Malformation Syndrome
Deafness-Imperforate Anus-Hypoplastic Thumbs Syndrome	Imperforate Anus-Hand And Foot Anomalies Syndrome
Sensorineural Deafness-Imperforate Anus-Hypoplastic Thumbs Syndrome	Sensorineural Hearing Loss With Imperforate Anus And Hypoplastic Thumbs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05663	GPR141 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GPR141	VGNC	VGNC:62675
Mus musculus	GPR141	MGD	MGI:2672983
Macaca mulatta	GPR141	VGNC	VGNC:81323
Canis familiaris	GPR141	VGNC	VGNC:41401
Bos taurus	GPR141	VGNC	VGNC:52783
Rattus norvegicus	GPR141	RGD	RGD:727906

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