IMPA1 - inositol monophosphatase 1 Gene

Homo sapiens

Also known as IMP; IMPA; MRT59

Gene ID: 3612 | Gene type: protein coding

About IMPA1

Cytogenetic location: 8q21.13 Genomic coordinates (GRCh38): 8:81,656,914-81,686,325 (from NCBI)

This gene has 13 transcripts (splice variants), 232 orthologues, 4 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 15.5), thyroid (RPKM 10.4) and 24 other tissues.

Summary

This gene encodes an Enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This Enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This Enzyme shows magnesium-dependent Phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Dec 2014]

IMPA1 Products(3)

mRNA	Protein	Name
NM_001144878.2	NP_001138350.1	inositol monophosphatase 1 isoform 2
NM_001144879.2	NP_001138351.1	inositol monophosphatase 1 isoform 3
NM_005536.4	NP_005527.1	inositol monophosphatase 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables inositol monophosphate 1-phosphatase activity	IDA IDA: Inferred from direct assay	17068342	GOA
enables inositol monophosphate 1-phosphatase activity	IMP IMP: Inferred from mutant phenotype	1377913	GOA
enables inositol monophosphate phosphatase activity	IDA IDA: Inferred from direct assay	9462881	GOA
enables lithium ion binding	IDA IDA: Inferred from direct assay	9462881	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	9462881	GOA
enables manganese ion binding	IDA IDA: Inferred from direct assay	9462881	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	17068342	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in phosphate-containing compound metabolic process	IMP IMP: Inferred from mutant phenotype	1377913	GOA
involved in phosphatidylinositol biosynthetic process	IMP IMP: Inferred from mutant phenotype	1377913	GOA
involved in signal transduction	IMP IMP: Inferred from mutant phenotype	1377913	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	1377913	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IMPA1 Protein Structure

Inositol_P

0
100
200
277 a.a.

Protein Preferred Names

Protein Names

inositol monophosphatase 1

D-galactose 1-phosphate phosphatase

Recombinant IMPA1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70335	IMPA1 Protein, Human (His)	P29218-1 (M1-D277)	≥95%

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, Autosomal Recessive 59

MRT59	Mental Retardation, Autosomal Recessive 59
Autosomal Recessive Intellectual Developmental Disorder 59

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Mood Disorder

Mood Disorders

Episodic Mood Disorder

Spastic Paraplegia, Optic Atrophy, And Neuropathy

Spoan Syndrome	SPOAN
Spastic Paraplegia, Optic Atropy, And Neuropathy	Spastic Paraplegia, Optic Atropy, And Neuropathy Syndrome
Spastic Paraplegia-Optic Atrophy-Neuropathy Syndrome

Developmental And Epileptic Encephalopathy 11

Epileptic Encephalopathy, Early Infantile, 11	DEE11
Eiee11	Developmental And Epileptic Encephalopathy, 11
Early Infantile Epileptic Encephalopathy 11	Encephalopathy, Developmental And Epileptic, Type 11

Cardiomyopathy, Familial Hypertrophic, 1

Asymmetric Septal Hypertrophy	Familial Hypertrophic Cardiomyopathy
Hypertrophic Cardiomyopathy 1	CMH1
Hypertrophic Cardiomyopathy 19	CMH
Ventricular Hypertrophy, Hereditary	Ash
Hypertrophic Subaortic Stenosis, Idiopathic	Cardiomyopathy, Familial Hypertrophic
Cardiomyopathy, Hypertrophic, 1, Digenic	Cardiomyopathy, Familial Hypertrophic 1
Hcm	Hereditary Ventricular Hypertrophy
Idiopathic Hypertrophic Subaortic Stenosis	Hypertrophic Cardiomyopathy
Cardiomyopathy, Hypertrophic, Familial	Cardiomyopathy, Hypertrophic, 1
Familial Asymmetric Septal Hypertrophy	Heritable Hypertrophic Cardiomyopathy
Fhc	Cardiomyopathy, Hypertrophic, Familial, Type 1

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125053A	Batifiban TFA	Antagonist	99.58%	Unkown
HY-P1390	d[Cha4]-AVP	Agonist	99.27%	Unkown
HY-P10046	[Deamino-Pen1,Val4,D-Arg8]-vasopressin	Inhibitor	/	Unkown
HY-P4397	(d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin		/	Unkown
HY-P5006	(d(CH2)51,Tyr(Me)2,Dab5,Arg8)-Vasopressin	Antagonist	/	Unkown
HY-RS06795	IMPA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-125053	Batifiban		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	IMPA1	VGNC	VGNC:42007
Bos taurus	IMPA1	VGNC	VGNC:30184
Mus musculus	IMPA1	MGD	MGI:1933158
Macaca mulatta	IMPA1	VGNC	VGNC:84008
Rattus norvegicus	IMPA1	RGD	RGD:69254
Felis catus	IMPA1	VGNC	VGNC:67796
Others	IMPA1	NCBI

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