2. Gene
  3. Brd7 - bromodomain containing 7 Gene

Brd7 - bromodomain containing 7 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 361374 | Gene type: protein coding

About Brd7

Primary_assembly 19: 18,709,022-18,737,494 forward strand.mRatBN7.2:CM026992.1

This gene has 1 transcript (splice variant), 223 orthologues, 2 paralogues and is associated with 9 phenotypes. Biased expression in Thymus (RPKM 197.7), Spleen (RPKM 165.8) and 9 other tissues.

Summary

Predicted to enable several functions, including lysine-acetylated histone binding activity; p53 binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; positive regulation of histone acetylation; and regulation of transcription, DNA-templated. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human BRD7 (bromodomain containing 7). [provided by Alliance of Genome Resources, Apr 2022]

Brd7 Products(2)

mRNA Protein Name
NM_001401243.1 NP_001388172.1 bromodomain-containing protein 7 isoform 2
NM_001401242.1 NP_001388171.1 bromodomain-containing protein 7 isoform 1

Brd7 Protein Structure

Bromo_brd7_like

Bromo_brd7_like: cd05513 (134 - 231)

DUF3512

DUF3512: pfam12024 (301 - 484)

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  • 655 a.a.
Protein Preferred Names Protein Names

bromodomain-containing protein 7

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-114322 VZ185 Inhibitor 98.00% Unkown
HY-100352 BI-9564 Inhibitor 98.73% Unkown
HY-110374 NVS-CECR2-1 Inhibitor 99.40% Unkown
HY-100517 TP-472 Inhibitor 99.52% Unkown
HY-101121 NI-42 Inhibitor 99.53% Unkown
HY-149806 Bromodomain IN-2 Inhibitor / Unkown
HY-116227 (2S,3R)-LP99 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Brd7 NCBI NCBI:29117