INSRR - insulin receptor related receptor Gene

Homo sapiens

Also known as IRR

Gene ID: 3645 | Gene type: protein coding

About INSRR

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:156,840,063-156,859,117 (from NCBI)

This gene has 1 transcript (splice variant), 124 orthologues and 53 paralogues. Biased expression in kidney (RPKM 1.2), testis (RPKM 1.1) and 5 other tissues.

Summary

Enables transmembrane receptor protein tyrosine kinase activity. Involved in actin Cytoskeleton reorganization; cellular response to alkaline pH; and protein autophosphorylation. Part of receptor complex. [provided by Alliance of Genome Resources, Apr 2022]

INSRR Products(1)

mRNA	Protein	Name
NM_014215.3	NP_055030.1	insulin receptor-related protein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22939624	GOA
enables transmembrane receptor protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	21641549	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin cytoskeleton organization	IDA IDA: Inferred from direct assay	21641549	GOA
involved in cellular response to alkaline pH	IDA IDA: Inferred from direct assay	21641549	GOA
involved in protein autophosphorylation	IMP IMP: Inferred from mutant phenotype	21641549	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

INSRR Protein Structure

Recep_L_domain

Furin-like

Recep_L_domain

fn3

Pkinase_Tyr

0
200
400
600
800
1000
1200
1297 a.a.

Protein Preferred Names

Protein Names

insulin receptor-related protein

IR-related receptor

INSRR Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	INSRR	P14616	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	INSRR	P14616	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	INSRR	P14616	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	INSRR	P14616	HSP90AB1	Homo sapiens	P08238	Affinity Chrom	35384245
Intra	INSRR	P14616	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	33961781
Intra	INSRR	P14616	HSP90AB1	Homo sapiens	P08238	BioID	35384245
Intra	INSRR	P14616	INSR	Homo sapiens	P06213	Anti Tag CoIP	33961781
Intra	INSRR	P14616	INSR	Homo sapiens	P06213	BioID	35384245
Intra	INSRR	P14616	INSR	Homo sapiens	P06213	Affinity Chrom	35384245

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Rickettsialpox

Vesicular Rickettsiosis	Rickettsia Akari Spotted Fever
Doid:11103	Rickettsiaceae Infections
Kew Gardens Spotted Fever	Rickettsia Akari Smallpox
Rickettsia Akari Infection

Regular Astigmatism

Cone-Rod Dystrophy 12

CORD12

Dystrophy, Cone-Rod, Type 12

Familial Atrial Fibrillation

Atrial Fibrillation, Familial	Atfb
Atrial Fibrillation Autosomal Dominant	Autosomal Dominant Atrial Fibrillation
Auricular Fibrillation	Atrial Fibrillation
Atrial Fibrillation, Familial, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06849	INSRR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	INSRR	VGNC	VGNC:42044
Rattus norvegicus	INSRR	RGD	RGD:67399
Bos taurus	INSRR	VGNC	VGNC:30222
Felis catus	INSRR	VGNC	VGNC:67812
Mus musculus	INSRR	MGD	MGI:1346037
Macaca mulatta	INSRR	VGNC	VGNC:106390

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