IRF5 - interferon regulatory factor 5 Gene

Homo sapiens

Also known as SLEB10

Gene ID: 3663 | Gene type: protein coding

About IRF5

Cytogenetic location: 7q32.1 Genomic coordinates (GRCh38): 7:128,937,032-128,950,038 (from NCBI)

This gene has 22 transcripts (splice variants), 218 orthologues, 8 paralogues and is associated with 8 phenotypes. Broad expression in spleen (RPKM 8.6), lymph node (RPKM 6.5) and 25 other tissues.

Summary

This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, Apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Dec 2016]

IRF5 Products(7)

mRNA	Protein	Name
NM_001098627.4	NP_001092097.2	interferon regulatory factor 5 isoform b
NM_001098629.3	NP_001092099.1	interferon regulatory factor 5 isoform d
NM_001098630.3	NP_001092100.1	interferon regulatory factor 5 isoform b
NM_001242452.3	NP_001229381.1	interferon regulatory factor 5 isoform e
NM_001347928.2	NP_001334857.1	interferon regulatory factor 5 isoform d
NM_001364314.2	NP_001351243.1	interferon regulatory factor 5 isoform d
NM_032643.5	NP_116032.1	interferon regulatory factor 5 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12600985	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	25326418	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	18836453	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18836453	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	25326418	GOA
enables sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	23332764	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to virus	IDA IDA: Inferred from direct assay	29046356	GOA
involved in cytokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	25326418	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	22412986	GOA
involved in positive regulation of cytokine production involved in immune response	IDA IDA: Inferred from direct assay	29046356	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12600985	GOA
involved in positive regulation of type I interferon production	IDA IDA: Inferred from direct assay	32433612	GOA
involved in response to muramyl dipeptide	IDA IDA: Inferred from direct assay	22412986	GOA
involved in response to peptidoglycan	IDA IDA: Inferred from direct assay	22412986	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	22412986	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22412986	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IRF5 Protein Structure

IRF

IRF-3

0
100
200
300
400
498 a.a.

Protein Preferred Names

Protein Names

interferon regulatory factor 5

Recombinant IRF5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70573	IRF5 Protein, Human	Q13568-1 (M1-Q498)	≥95%

Related Diseases

Diseases

Alias

Systemic Lupus Erythematosus 10

Systemic Lupus Erythematosus, Susceptibility To, 10	SLEB10
Lupus Erythematosus, Systemic, Type 10

Inflammatory Bowel Disease 14

IBD14	Inflammatory Bowel Disease 14, Susceptibility To
Bowel Disease, Inflammatory, Type 14

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Limited Scleroderma

Limited Cutaneous Systemic Sclerosis	Limited Systemic Sclerosis
Systemic Sclerosis Sine Scleroderma	Crest Syndrome
Limited Cutaneous Systemic Scleroderma	Scleroderma, Limited
Systemic Sclerosis, Limited	Progressive Systemic Sclerosis Sine Scleroderma
Scleroderma, Sine	Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome
Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Diffuse Cutaneous Systemic Sclerosis

Diffuse Cutaneous Systemic Scleroderma	Progressive Cutaneous Systemic Scleroderma
Progressive Cutaneous Systemic Sclerosis	Dcssc
Diffuse Scleroderma

Primary Biliary Cholangitis

Primary Biliary Cirrhosis	Biliary Liver Cirrhosis
Chronic Nonsuppurative Destructive Cholangitis	Familial Primary Biliary Cirrhosis
Pbc	Hanot Syndrome
Cholestatic Cirrhosis	Biliary Cirrhosis Primary
Liver Cirrhosis, Biliary	Hanot'S Cirrhosis
Biliary Cirrhosis	Pericholangiolic Biliary Cirrhosis
Tannhauser-Magendantz Syndrome	Hanot-Rossle Syndrome
Hypertrophic Cirrhosis	Todd Cirrhosis
Hanot Cirrhosis	Charcot Cirrhosis
Mahon-Tannhauser Syndrome	Toxic Cirrhosis
Hypertrophic Biliary Cirrhosis	Monolobular Cirrhosis
Unilobar Cirrhosis	Xanthomatous Biliary Cirrhosis

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Ulcerative Colitis

Colitis Gravis	Left Sided Ulcerative Colitis
Left-Sided Ulcerative Colitis	Idiopathic Proctocolitis
Inflammatory Bowel Disease, Ulcerative Colitis Type	Uc
Colitis Ulcerative	Colitis, Ulcerative
Chronic Left-Sided Ulcerative Colitis	Uc - [Ulcerative Colitis]
Chronic Ulcerative Enteritis	Mucosal Proctocolitis
Ulcerative Mucosal Proctocolitis	Left Hemicolitis

Colitis

Autoimmune Disease

Autoimmune Diseases	Autoimmune Hypersensitivity Disease
Hypersensitivity Reaction Type Ii Disease	Type Ii Hypersensitivity Reaction Disease

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Systemic Scleroderma

Scleroderma	Progressive Systemic Sclerosis
Systemic Sclerosis	Scleroderma, Systemic
Scleroderma Syndrome	Dermatosclerosis
Familial Progressive Scleroderma	Progressive Scleroderma
Scleroderma Disease	Scleroderma, Localized
Diffuse Scleroderma	Scleroderma, Familial Progressive

Macrophage Activation Syndrome

Autoimmune Disease Of Exocrine System

Chilblain Lupus 1

Chilblain Lupus	CHBL1
Chilblain Lupus Erythematosus	Chle
Hutchinson Lupus	Chilblain Lupus, Type 1

Potocki-Shaffer Syndrome

Proximal 11p Deletion Syndrome	Chromosome 11p11.2 Deletion Syndrome
Pss	11p11.2 Deletion
P11pds	Defect11 Syndrome
Deletion Of Chromosome 11p11.2	POSHS

Cutaneous Lupus Erythematosus

Lupus Erythematosus, Cutaneous

Lupus Erythematosus Cutaneous

Uterine Adnexa Cancer

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-149652	IRF5-IN-1		99.91%	Unkown
HY-150095	YE6144	Inhibitor	99.86%	Unkown
HY-RS06909	IRF5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	IRF5	RGD	RGD:1310447
Macaca mulatta	IRF5	VGNC	VGNC:73763
Canis familiaris	IRF5	VGNC	VGNC:42094
Felis catus	IRF5	VGNC	VGNC:67827
Mus musculus	IRF5	MGD	MGI:1350924
Bos taurus	IRF5	VGNC	VGNC:30276
Others	IRF5	NCBI

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