2. Gene
  3. MAVS - mitochondrial antiviral signaling protein Gene

MAVS - mitochondrial antiviral signaling protein Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as IPS1; VISA; IPS-1; CARDIF

Gene ID: 57506 | Gene type: protein coding

About MAVS

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:3,846,834-3,876,118 (from NCBI)

This gene has 2 transcripts (splice variants) and 142 orthologues. Ubiquitous expression in colon (RPKM 9.9), fat (RPKM 9.0) and 25 other tissues.

Summary

This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to Antiviral innate immunity. [provided by RefSeq, Jul 2020]

MAVS Products(3)

mRNA Protein Name
NM_001206491.2 NP_001193420.1 mitochondrial antiviral-signaling protein isoform 2
NM_001385663.1 NP_001372592.1 mitochondrial antiviral-signaling protein isoform 2
NM_020746.5 NP_065797.2 mitochondrial antiviral-signaling protein isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables CARD domain binding IPI
IPI: Inferred from physical interaction
16127453 GOA
enables RIG-I binding IDA
IDA: Inferred from direct assay
16127453 GOA
enables identical protein binding IDA
IDA: Inferred from direct assay
16127453 GOA
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
16858409 GOA
enables molecular condensate scaffold activity IDA
IDA: Inferred from direct assay
27992402 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16127453 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
16127453 GOA
enables signaling adaptor activity IDA
IDA: Inferred from direct assay
20451243 GOA
enables signaling adaptor activity IMP
IMP: Inferred from mutant phenotype
20451243 GOA
Biological Process GO Annotation Evidence Reference Source
involved in activation of innate immune response IDA
IDA: Inferred from direct assay
20628368 GOA
involved in activation of innate immune response IMP
IMP: Inferred from mutant phenotype
18818105 GOA
involved in antiviral innate immune response IDA
IDA: Inferred from direct assay
27992402 GOA
involved in cellular response to exogenous dsRNA IMP
IMP: Inferred from mutant phenotype
16127453 GOA
involved in cytoplasmic pattern recognition receptor signaling pathway IDA
IDA: Inferred from direct assay
16125763 GOA
involved in defense response to bacterium IMP
IMP: Inferred from mutant phenotype
19631370 GOA
involved in defense response to virus IDA
IDA: Inferred from direct assay
20451243 GOA
acts upstream of positive effect innate immune response IDA
IDA: Inferred from direct assay
23951545 GOA
involved in innate immune response IMP
IMP: Inferred from mutant phenotype
19609254 GOA
involved in negative regulation of type I interferon-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
37656786 GOA
involved in negative regulation of viral genome replication IDA
IDA: Inferred from direct assay
20451243 GOA
involved in positive regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
16127453 GOA
involved in positive regulation of IP-10 production IDA
IDA: Inferred from direct assay
16127453 GOA
involved in positive regulation of NLRP3 inflammasome complex assembly IDA
IDA: Inferred from direct assay
23582325 GOA
involved in positive regulation of chemokine (C-C motif) ligand 5 production IDA
IDA: Inferred from direct assay
16127453 GOA
involved in positive regulation of defense response to virus by host IDA
IDA: Inferred from direct assay
16127453 GOA
involved in positive regulation of defense response to virus by host IMP
IMP: Inferred from mutant phenotype
19609254 GOA
involved in positive regulation of interferon-alpha production IDA
IDA: Inferred from direct assay
16127453 GOA
involved in positive regulation of interferon-alpha production IMP
IMP: Inferred from mutant phenotype
19609254 GOA
involved in positive regulation of interferon-beta production IDA
IDA: Inferred from direct assay
16127453 GOA
involved in positive regulation of interferon-beta production IMP
IMP: Inferred from mutant phenotype
19609254 GOA
involved in positive regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
21957149 GOA
involved in positive regulation of interleukin-8 production IDA
IDA: Inferred from direct assay
16127453 GOA
involved in positive regulation of protein import into nucleus IDA
IDA: Inferred from direct assay
18818105 GOA
involved in positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
16127453 GOA
involved in positive regulation of response to cytokine stimulus IMP
IMP: Inferred from mutant phenotype
21957149 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16127453 GOA
involved in positive regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
16127453 GOA
involved in positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
21957149 GOA
involved in positive regulation of type I interferon production IDA
IDA: Inferred from direct assay
16858409 GOA
involved in positive regulation of type I interferon-mediated signaling pathway IDA
IDA: Inferred from direct assay
16127453 GOA
involved in protein localization to mitochondrion IDA
IDA: Inferred from direct assay
23582325 GOA
involved in regulation of peroxisome organization IMP
IMP: Inferred from mutant phenotype
20451243 GOA
involved in signal transduction IMP
IMP: Inferred from mutant phenotype
20451243 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in mitochondrial membrane IDA
IDA: Inferred from direct assay
20451243 GOA
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
20451243 GOA
is active in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
16127453 GOA
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
18818105 GOA
is active in mitochondrion IDA
IDA: Inferred from direct assay
16127453 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
20628368 GOA
located in peroxisomal membrane IDA
IDA: Inferred from direct assay
20451243 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mitochondrial antiviral-signaling protein

CARD adapter inducing interferon beta

MAVS Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
MAVS Q7Z434 UBE4A Homo sapiens Q14139
Anti Tag CoIP
21903422
Intra
MAVS Q7Z434 MFN1 Homo sapiens Q8IWA4
Anti Bait CoIP
20019757
Intra
MAVS Q7Z434 CALR Homo sapiens P27797
Y2H Array
32814053
Intra
MAVS Q7Z434 CALR Homo sapiens P27797
Y2H Pooling
32814053
Intra
MAVS Q7Z434 CALR Homo sapiens P27797
Validated Y2H
32814053
Intra
MAVS Q7Z434 NEK7 Homo sapiens Q8TDX7
Y2H Pooling
32814053
Intra
MAVS Q7Z434 NEK7 Homo sapiens Q8TDX7
Validated Y2H
32814053
Intra
MAVS Q7Z434 NEK7 Homo sapiens Q8TDX7
Y2H Array
32814053
Intra
MAVS Q7Z434 STAT1 Homo sapiens P42224
Anti Bait CoIP
21903422
Intra
MAVS Q7Z434 STAT1 Homo sapiens P42224
Anti Tag CoIP
21903422
Cross
MAVS Q7Z434 vme1_sars2 SARS-CoV-2 P0DTC5
Anti Bait CoIP
33372174
Cross
MAVS Q7Z434 P0DTD1-PRO_0000449623 SARS-CoV-2 P0DTD1-PRO_0000449623
Enzymatic Study
34544279
Cross
MAVS Q7Z434 P0DTD1-PRO_0000449623 SARS-CoV-2 P0DTD1-PRO_0000449623
Anti Tag CoIP
34544279
Cross
MAVS Q7Z434 ns7b_sars2 SARS-CoV-2 P0DTD8
Y2H Array
36217030
Cross
MAVS Q7Z434 ns7b_sars2 SARS-CoV-2 P0DTD8
Anti Tag CoIP
33845483
Cross
MAVS Q7Z434 ns7b_sars Human SARS coronavirus Q7TFA1
Anti Tag CoIP
33845483
Intra
MAVS Q7Z434 STING1 Homo sapiens Q86WV6
Anti Tag CoIP
22911572
Intra
MAVS Q7Z434 STING1 Homo sapiens Q86WV6
Anti Bait CoIP
22000020
Intra
MAVS Q7Z434 TGFBR2 Homo sapiens P37173
Validated Y2H
32814053
Intra
MAVS Q7Z434 TGFBR2 Homo sapiens P37173
Y2H Array
32814053
Intra
MAVS Q7Z434 TGFBR2 Homo sapiens P37173
Y2H Pooling
32814053
Intra
MAVS Q7Z434 IKBKE Homo sapiens Q14164
Anti Tag CoIP
19153231
Intra
MAVS Q7Z434 IKBKE Homo sapiens Q14164
Anti Tag CoIP
16177806
Intra
MAVS Q7Z434 C1QBP Homo sapiens Q07021
Confocal
19164550
Intra
MAVS Q7Z434 C1QBP Homo sapiens Q07021
Anti Tag CoIP
19164550
Intra
MAVS Q7Z434 BAG6 Homo sapiens P46379
Anti Tag CoIP
21903422
Intra
MAVS Q7Z434 DLST Homo sapiens P36957
Validated Y2H
32814053
Intra
MAVS Q7Z434 DLST Homo sapiens P36957
Y2H Array
32814053
Intra
MAVS Q7Z434 DLST Homo sapiens P36957
Y2H Pooling
32814053
Intra
MAVS Q7Z434 DDX3X Homo sapiens O00571
Y2H
20127681
Intra
MAVS Q7Z434 TRAF2 Homo sapiens Q12933
Anti Tag CoIP
21903422
Intra
MAVS Q7Z434 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra
MAVS Q7Z434 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra
MAVS Q7Z434 RIPK2 Homo sapiens O43353
Anti Tag CoIP
21903422
Intra
MAVS Q7Z434 RIPK2 Homo sapiens O43353
Anti Bait CoIP
21903422
Intra
MAVS Q7Z434 TRAF6 Homo sapiens Q9Y4K3
BLI
26385923
Intra
MAVS Q7Z434 TRAF6 Homo sapiens Q9Y4K3
Anti Tag CoIP
21903422
Intra
MAVS Q7Z434 TRAF6 Homo sapiens Q9Y4K3
Pull Down
26385923
Intra
MAVS Q7Z434 TRAF6 Homo sapiens Q9Y4K3
X-Ray Diffraction
26385923
Intra
MAVS Q7Z434 ABL1 Homo sapiens P00519
Anti Tag CoIP
19914245
Intra
MAVS Q7Z434 IRF5 Homo sapiens Q13568
Anti Tag CoIP
21903422
Intra
MAVS Q7Z434 OAS3 Homo sapiens Q9Y6K5
Anti Tag CoIP
21903422
Intra
MAVS Q7Z434 IFIH1 Homo sapiens Q9BYX4
Anti Tag CoIP
22301138
Intra
MAVS Q7Z434 IFIH1 Homo sapiens Q9BYX4
Anti Bait CoIP
33372174
Intra
MAVS Q7Z434 NLRP3 Homo sapiens Q96P20
Anti Bait CoIP
23582325
Intra
MAVS Q7Z434 NLRP3 Homo sapiens Q96P20
Anti Tag CoIP
23582325
Intra
MAVS Q7Z434 CDH1 Homo sapiens P12830
Y2H Array
32814053
Intra
MAVS Q7Z434 CDH1 Homo sapiens P12830
Validated Y2H
32814053
Intra
MAVS Q7Z434 CDH1 Homo sapiens P12830
Y2H Pooling
32814053
Intra
MAVS Q7Z434 CALCOCO2 Homo sapiens Q13137
Anti Bait CoIP
21903422
Intra
MAVS Q7Z434 KCNIP3 Homo sapiens Q9Y2W7
Y2H Prey Pooling
25416956
Intra
MAVS Q7Z434 KCNIP3 Homo sapiens Q9Y2W7
Validated Y2H
25416956
Cross
MAVS Q7Z434 orf9b_sars Human SARS coronavirus P59636
Confocal
25135833
Cross
MAVS Q7Z434 orf9b_sars Human SARS coronavirus P59636
SRM
25135833
Cross
MAVS Q7Z434 orf9b_sars Human SARS coronavirus P59636
EM
25135833
Cross
MAVS Q7Z434 orf9b_sars Human SARS coronavirus P59636
Anti Tag CoIP
25135833
Intra
MAVS Q7Z434 RIGI Homo sapiens O95786
Anti Tag CoIP
19193793
Intra
MAVS Q7Z434 RIGI Homo sapiens O95786
Anti Tag CoIP
22301138
Intra
MAVS Q7Z434 RIGI Homo sapiens O95786
Anti Bait CoIP
33976430
Intra
MAVS Q7Z434 RIGI Homo sapiens O95786
Confocal
22623778
Intra
MAVS Q7Z434 RIGI Homo sapiens O95786
BiFC
24478431
Intra
MAVS Q7Z434 RIGI Homo sapiens O95786
Anti Tag CoIP
21102435
Intra
MAVS Q7Z434 RIGI Homo sapiens O95786
Anti Tag CoIP
21903422
Intra
MAVS Q7Z434 RIGI Homo sapiens O95786
Anti Bait CoIP
33372174
Cross
MAVS Q7Z434 M2 Human metapneumovirus Q6WB96
Anti Bait CoIP
23015697
Cross
MAVS Q7Z434 M2 Human metapneumovirus Q6WB96
Anti Tag CoIP
23015697
Cross
MAVS Q7Z434 nsp1_rotsh Rotavirus A A2T3M4
Anti Tag CoIP
24643253
Cross
MAVS Q7Z434 nsp1_rotsh Rotavirus A A2T3M4
Anti Bait CoIP
24643253
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Mouth Disease

Mouth Diseases

Mouth Disorders
Hepatitis

Chronic Hepatitis

Chronic Persistent Hepatitis

Acute Hepatitis

Hepatitis, Chronic

Acute And Subacute Liver Necrosis

Acute/Subac. Necrosis Of Liver

Animal Hepatitis

Hepatitis Chronic

Hepatitis A

Hepatitis, Animal

Hepatitis Due To Toxoplasmosis

Hepatitis In Toxoplasmosis

Toxoplasmal Hepatitis

Chronic Hepatitis, Unspecified

Chronic Active Hepatitis Nec

Other Specified Chronic Hepatitis

Chronic Persistent Hepatitis Nec

Chronic Lobular Hepatitis Nec
Oropouche Fever

Oropouche Virus Disease

Oropouche Mosquito-Borne Viral Fever
Newcastle Disease

Newcastle'S Disease

Pseudo-Fowlpest
Hepatitis C

Chronic Hepatitis C

Hepatitis C Infection

Hepatitis Nona Nonb

Nanbh

Viral Hepatitis C

Hepatitis C Chronic

Hepatitis C, Chronic

Chronic Type C Viral Hepatitis

Chronic Hcv - [Hepatitis C Virus] Infection

Hepatitis C Nos

Hepatitis C Infection Nos

Hepatitis C-Related Cirrhosis

Type C Viral Hepatitis

Hep C Nos
Viral Infectious Disease

Viral Disease

Arbovirus Infections

Virus Infection

Virus Diseases

Viral Infection

Viral Infections

Virus Infections
Vaccinia
Lymphocytic Choriomeningitis

Lcm

Lymphocytic Meningitis

Lymphocytic Choriomeningitis Virus Encephalomyelitis

Lymphocytic Meningoencephalitis

Non-Arthropod Borne Lymphocytic Choriomeningitis

Lcm - [Lymphocytic Choriomeningitis]

Benign Lymphocytic Meningitis

Meningitis Due To Lymphocytic Choriomeningitis Virus
Hepatitis A

Viral Hepatitis A

Viral Hepatitis, Type A
Hepatitis C Virus

Hepatitis C Virus, Susceptibility To

Hepatitis C Virus Infection, Response To Therapy Of

Hcv

Hcv, Susceptibility To

Hepatitis C Virus, Resistance To

Hepatitis C Virus, Response To Therapy Of

Resistance To Hepatitis C Virus
Chikungunya

Chikungunya Fever

Arbovirus A Chikungunya Type

Chik

Chikv Infection

Ck

Chikungunya Virus Infection

Chikungunya Haemorrhagic Fever

Chikungunya Viral Disease

Chikungunya Mosquito-Borne Viral Fever
Severe Acute Respiratory Syndrome

Sars

Sars-Cov Infection

Sars-1

Sar Deficiency

Sars - [Severe Acute Respiratory Syndrome]
Rubella

German Measles

Three Day Measles

Rubella Nos
Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome

Cree Encephalitis

Aicardi-Goutières Syndrome

Encephalopathy With Basal Ganglia Calcification

Ags

Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

Pseudotoxoplasmosis Syndrome

Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

Aicardi-Goutieres Syndrome 1
Microphthalmia With Limb Anomalies

Waardenburg Anophthalmia Syndrome

Ophthalmoacromelic Syndrome

OAS

MLA

Anophthalmia-Syndactyly

Anophthalmia-Syndactyly Syndrome

Anophthalmos With Limb Anomalies

Anophthalmia Waardenburg Syndrome

Anophthalmos-Syndactyly

Ophthalmo-Acromelic Syndrome

Anophthalmia-Waardenburg Syndrome

Anophthalmos-Limb Anomalies Syndrome

Syndactyly-Anophthalmos Syndrome

Microphthalmia, With Limb Anomalies
Combined Oxidative Phosphorylation Deficiency 4

COXPD4

Combined Oxidative Phosphorylation Defect Type 4

Combined Oxidative Phosphorylation Deficiency, Type 4
Sting-Associated Vasculopathy With Onset In Infancy

Savi

Sting-Associated Vasculopathy, Infantile Onset

Sting-Associated Vasculopathy, Infantile-Onset
Avian Influenza

Bird Flu

Influenza In Birds

Avian Flu
Dyschromatosis Symmetrica Hereditaria

Dyschromatosis Symmetrica Hereditaria 1

Reticulate Acropigmentation Of Dohi

DSH

Dsh1

Symmetric Dyschromatosis Of The Extremities

Rad

Familial Reticulate Acropigmentation Of Dohi

Acropigmentation Of Dohi

Symmetrical Dyschromatosis Of Extremities
Chilblain Lupus 1

Chilblain Lupus

CHBL1

Chilblain Lupus Erythematosus

Chle

Hutchinson Lupus

Chilblain Lupus, Type 1
Argentine Hemorrhagic Fever

Argentinian Hemorrhagic Fever

Junin Hemorrhagic Fever

Hemorrhagic Fever, Argentinian

Ahf - [Argentinian Haemorrhagic Fever]

Argentine Haemorrhagic Fever

Junin Haemorrhagic Fever
Poliomyelitis

Polio

Infantile Paralysis
Vasculopathy, Retinal, With Cerebral Leukoencephalopathy And Systemic Manifestations

Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations

Crv

Rvcl

Rvcl-S

Vasculopathy, Retinal, With Cerebral Leukodystrophy

Retinopathy, Vascular, With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena

Retinal Vasculopathy With Cerebral Leukodystrophy

Retinal Vasculopathy And Cerebral Leukoencephalopathy

Hereditary Vascular Retinopathy

Hvr

RVCLS

Cerebroretinal Vasculopathy, Hereditary

Cerebroretinal Vasculopathy

Herns

Vasculopathy, Retinal, With Cerebral Leukodystrophy, Formerly

Hereditary Cerebroretinal Vasculopathy

Hereditary Endotheliopathy, Retinopathy, Nephropathy, Stroke

Hereditary Systemic Angiopathy

Hsa

Retinal Vasculopathy With Cerebral Leukodystrophy With Systemic Manifestations

Adrvcl

Autosomal Dominant Retinal Vasculopathy With Cerebral Leukodystrophy

Hereditary Endotheliopathy With Retinopathy-Nephropathy-Stroke

Vascular Retinopathy With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena
Peroxisomal Biogenesis Disorder

Zellweger Spectrum Disorders

Peroxisome Biogenesis Disorder-Zellweger Syndrome Spectrum

Disorders Of Peroxisome Biogenesis

Zellweger Spectrum

Zellweger Syndrome Spectrum

Peroxisomal Biogenesis Disorders

Pbd, Zss

Pbd-Zsd

Pbd-Zss

Pbd-Zellweger Spectrum Disorder

Peroxisomal Biogenesis Disorders, Zellweger Syndrome Spectrum

Peroxisome Biogenesis Disorder

Peroxisome Biogenesis Disorder Spectrum

Peroxisome Biogenesis Disorders

Zellweger Spectrum Disorder

Hyperpipecolic Acidaemia
Zellweger Syndrome

Cerebrohepatorenal Syndrome

Zellweger Leukodystrophy

Zs

Congenital Iron Overload

Chr

Zws

Severe Pbd-Zsd

Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-123805 KIN1400 98.1% Unkown
HY-RS08176 MAVS Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-113687 T145 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MAVS VGNC VGNC:63397
Mus musculus MAVS MGD MGI:2444773
Rattus norvegicus MAVS RGD RGD:1359371
Canis familiaris MAVS VGNC VGNC:43044
Macaca mulatta MAVS VGNC VGNC:74609
Bos taurus MAVS VGNC VGNC:31268
Others MAVS NCBI