2. Gene
  3. TRIM28 - tripartite motif containing 28 Gene

TRIM28 - tripartite motif containing 28 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as KAP1; TF1B; RNF96; TIF1B; PPP1R157; TIF1beta

Gene ID: 10155 | Gene type: protein coding

About TRIM28

Cytogenetic location: 19q13.43 Genomic coordinates (GRCh38): 19:58,544,064-58,550,715 (from NCBI)

This gene has 15 transcripts (splice variants), 143 orthologues, 80 paralogues and is associated with 1 phenotype. Ubiquitous expression in ovary (RPKM 89.1), testis (RPKM 80.5) and 25 other tissues.

Summary

The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008]

TRIM28 Products(1)

mRNA Protein Name
NM_005762.3 NP_005753.1 transcription intermediary factor 1-beta
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA binding IDA
IDA: Inferred from direct assay
9016654 GOA
enables Krueppel-associated box domain binding IDA
IDA: Inferred from direct assay
17512541 GOA
enables SUMO transferase activity EXP
EXP: Inferred from Experiment
17298944 GOA
enables chromatin binding IDA
IDA: Inferred from direct assay
27029610 GOA
enables chromo shadow domain binding IPI
IPI: Inferred from physical interaction
15882967 GOA
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
24623306 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9016654 GOA
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
8769649 GOA
enables ubiquitin protein ligase activity IMP
IMP: Inferred from mutant phenotype
36354136 GOA
enables ubiquitin protein ligase binding IDA
IDA: Inferred from direct assay
18082607 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
18082607 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
10653693 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA repair IDA
IDA: Inferred from direct assay
17178852 GOA
involved in innate immune response IDA
IDA: Inferred from direct assay
18248090 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
9016654 GOA
involved in positive regulation of DNA methylation-dependent heterochromatin formation IMP
IMP: Inferred from mutant phenotype
24623306 GOA
involved in positive regulation of DNA repair IDA
IDA: Inferred from direct assay
17178852 GOA
involved in positive regulation of protein import into nucleus IDA
IDA: Inferred from direct assay
23665872 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
36354136 GOA
involved in protein sumoylation IDA
IDA: Inferred from direct assay
18082607 GOA
involved in suppression of viral release by host IDA
IDA: Inferred from direct assay
18248090 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
8769649 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
17512541 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM28 Protein Structure

zf-RING_5

zf-RING_5: zinc-RING finger domain (64 - 122)

zf-B_box

zf-B_box: B-box zinc finger (150 - 194)

zf-B_box

zf-B_box: B-box zinc finger (207 - 243)

PHD

PHD: PHD-finger (627 - 670)

  • 0
  • 200
  • 400
  • 600
  • 835 a.a.
Protein Preferred Names Protein Names

transcription intermediary factor 1-beta

E3 SUMO-protein ligase TRIM28

TRIM28 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TRIM28 Q13263 MAGEA6 Homo sapiens P43360
Pull Down
20864041
Intra
TRIM28 Q13263 ZNF10 Homo sapiens P21506
Anti Tag CoIP
35271311
Intra
TRIM28 Q13263 ZFP90 Homo sapiens Q8TF47-3
Anti Tag CoIP
23543754
Intra
TRIM28 Q13263 ZNF84 Homo sapiens P51523
Anti Tag CoIP
33961781
Intra
TRIM28 Q13263 NCOR1 Homo sapiens O75376
Chromatography
11013263
Intra
TRIM28 Q13263 NCOR1 Homo sapiens O75376
IF
11013263
Intra
TRIM28 Q13263 ZNF350 Homo sapiens Q9GZX5
Anti Tag CoIP
22975076
Intra
TRIM28 Q13263 ZNF649 Homo sapiens Q9BS31
Anti Tag CoIP
33961781
Intra
TRIM28 Q13263 ZNF649 Homo sapiens Q9BS31
Anti Tag CoIP
35271311
Intra
TRIM28 Q13263 CHD3 Homo sapiens Q12873
Y2H Pooling
16169070
Intra
TRIM28 Q13263 CHD3 Homo sapiens Q12873
Anti Tag CoIP
21642969
Intra
TRIM28 Q13263 MAGEA2 Homo sapiens P43356
Pull Down
20864041
Intra
TRIM28 Q13263 MAGEA2 Homo sapiens P43356
TAP
20864041
Intra
TRIM28 Q13263 MAGEA2 Homo sapiens P43356
Ubiquitinase Assay
20864041
Intra
TRIM28 Q13263 MAGEA2 Homo sapiens P43356
Anti Tag CoIP
20864041
Intra
TRIM28 Q13263 MAGEA3 Homo sapiens P43357
Pull Down
20864041
Intra
TRIM28 Q13263 MAGEC2 Homo sapiens Q9UBF1
Anti Bait CoIP
20864041
Intra
TRIM28 Q13263 MAGEC2 Homo sapiens Q9UBF1
GMS
20864041
Intra
TRIM28 Q13263 MAGEC2 Homo sapiens Q9UBF1
Anti Bait CoIP
21277283
Intra
TRIM28 Q13263 MAGEC2 Homo sapiens Q9UBF1
IF
20864041
Intra
TRIM28 Q13263 MAGEC2 Homo sapiens Q9UBF1
Pull Down
20864041
Intra
TRIM28 Q13263 MAGEC2 Homo sapiens Q9UBF1
Ubiquitinase Assay
20864041
Intra
TRIM28 Q13263 MAGEC2 Homo sapiens Q9UBF1
Anti Tag CoIP
20864041
Intra
TRIM28 Q13263 ZNF136 Homo sapiens P52737
Anti Tag CoIP
33961781
Intra
TRIM28 Q13263 ZNF136 Homo sapiens P52737
Anti Tag CoIP
31403225
Cross
TRIM28 Q13263 Cbx1 Mus musculus P83917
Pull Down
10330177
Intra
TRIM28 Q13263 CBX3 Homo sapiens Q13185
Pull Down
10330177
Intra
TRIM28 Q13263 CBX3 Homo sapiens Q13185
Anti Tag CoIP
33961781
Intra
TRIM28 Q13263 CBX3 Homo sapiens Q13185
Anti Tag CoIP
35271311
Intra
TRIM28 Q13263 CBX5 Homo sapiens P45973
Pull Down
10330177
Intra
TRIM28 Q13263 CBX5 Homo sapiens P45973
Anti Tag CoIP
33961781
Intra
TRIM28 Q13263 CBX5 Homo sapiens P45973
Y2H
20562864
Intra
TRIM28 Q13263 CBX5 Homo sapiens P45973
Anti Tag CoIP
35271311
Intra
TRIM28 Q13263 ZNF765 Homo sapiens Q7L2R6
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Wilms Tumor 1

Nephroblastoma

Wilms Tumor

WT1

Wilms' Tumor

Bilateral Wilms Tumor

Wilms Tumor, Type 1

Wilms Tumor, Somatic

Adult Nephroblastoma

Wt1 Disorder

Renal Embryonic Tumor

Adult Kidney Wilms Tumor

Childhood Kidney Wilms Tumor

Nonanaplastic Kidney Wilms Tumor
Wilms Tumor 5

Wilms Tumor

WT5

Wilms Tumor Susceptibility-5

Wilms Tumor And Radial Bilateral Aplasia

Nephroblastoma

Wilms' Tumor

Wilms Tumor, Susceptibility To

Wtsl

Bilateral Radial Aplasia With Wilms Tumor

Embryonal Adenosarcoma

Embryonal Nephroma

Kidney Wilms Tumor

Kidney, Adenomyosarcoma, Embryonal

Kidney, Carcinosarcoma, Embryonal

Kidney, Embryoma

Kidney, Embryonal Mixed Tumor

Nephroma

Renal Adenosarcoma

Renal Cancer, Wilms

Renal Wilms Tumor

Tumor, Wilms

Hereditary Susceptibility To Wilms Tumor 5
Hyperoxaluria, Primary, Type I

Primary Hyperoxaluria Type 1

HP1

Glycolic Aciduria

Alanine-Glyoxylate Aminotransferase Deficiency

Hepatic Agt Deficiency

Oxalosis I

Primary Hyperoxaluria, Type I

Serine:Pyruvate Aminotransferase Deficiency

Hyperoxaluria, Primary, Type 1

Peroxisomal Alanine-Glyoxylate Aminotransferase Deficiency

Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency

Serine Pyruvate Aminotransferase Deficiency

Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency

Oxalosis 1

Hyperoxaluria Primary 1

Hyperoxaluria Primary Type I

Ph1

Primary Hyperoxaluria Type I

Oxalosis Type 1

2-Oxoglutarate Glyoxylate Carboligase Deficiency
Primary Hyperoxaluria

Hyperoxaluria

Hyperoxaluria, Primary

Oxalosis

Primary Oxalosis

Congenital Oxaluria

D-Glycerate Dehydrogenase Deficiency

Glyceric Aciduria

Glycolic Aciduria

Hepatic Agt Deficiency

Oxaluria, Primary

Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency

Primary Oxaluria

Hyperoxaluria Primary

Primary Hyperoxaluria Type 2

Primary Hyperoxaluria, Type I
Hereditary Wilms' Tumor

Hereditary Wilms Tumor

Hereditary Wilms Tumour

Hereditary Wilms' Tumour

Wt1
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Burkitt Lymphoma

Burkitt'S Lymphoma

BL

Burkitt Lymphoma, Somatic

Burkitt Lymphoma/Leukaemia

Burkitt'S Tumor

Burkitt'S Tumor Or Lymphoma

Malignant Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma

Burkitt Tumor

Burkitts Lymphoma

Lymphoma, Small Noncleaved-Cell

Burkitt Tumour

Diffuse Small Noncleaved Malignant Burkitt Lymphoma

Malignant Burkitt Lymphoma

“Burkitt-Like” Lymphoma

Undifferentiated Burkitt Lymphoma

Small Noncleaved Cell Burkitt Lymphoma
Transient Neonatal Diabetes Mellitus

Diabetes Mellitus, Transient Neonatal

Tndm

Chromosome 6-Associated Transient Diabetes Mellitus

Dmtn

Diabetes Mellitus, 6q24-Related Transient Neonatal

Tndm1

Neonatal Diabetes Mellitus, Transient

Tndm -[Transient Neonatal Diabetes Mellitus]
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15033 TRIM28 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TRIM28 RGD RGD:620289
Macaca mulatta TRIM28 VGNC VGNC:79033
Bos taurus TRIM28 VGNC VGNC:36324
Felis catus TRIM28 VGNC VGNC:82332
Mus musculus TRIM28 MGD MGI:109274
Canis familiaris TRIM28 VGNC VGNC:47811