CATIP - ciliogenesis associated TTC17 interacting protein Gene

Homo sapiens

Also known as C2orf62

Gene ID: 375307 | Gene type: protein coding

About CATIP

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,356,857-218,368,094 (from NCBI)

This gene has 5 transcripts (splice variants), 183 orthologues, 1 paralogue and is associated with 1 phenotype. Biased expression in testis (RPKM 1.8), kidney (RPKM 1.1) and 13 other tissues.

Summary

Involved in actin filament polymerization and cilium organization. Located in several cellular components, including actin cytoskeleton; nucleus; and plasma membrane. Implicated in spermatogenic failure. [provided by Alliance of Genome Resources, Apr 2022]

CATIP Products(2)

mRNA	Protein	Name
NM_001320865.2	NP_001307794.1	ciliogenesis-associated TTC17-interacting protein isoform 1
NM_198559.2	NP_940961.1	ciliogenesis-associated TTC17-interacting protein isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24475127	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin filament polymerization	IDA IDA: Inferred from direct assay	32503832	GOA
involved in actin filament polymerization	IMP IMP: Inferred from mutant phenotype	24475127	GOA
involved in cilium organization	IMP IMP: Inferred from mutant phenotype	24475127	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	24475127	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	24475127	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24475127	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	24475127	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ciliogenesis-associated TTC17-interacting protein

CATIP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CATIP	Q7Z7H3	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	CATIP	Q7Z7H3	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	CATIP	Q7Z7H3	KRTAP10-9	Homo sapiens	P60411	Y2H Array	25416956
Intra	CATIP	Q7Z7H3	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	CATIP	Q7Z7H3	KRTAP10-7	Homo sapiens	P60409	Y2H Array	25416956
Intra	CATIP	Q7Z7H3	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	25416956
Intra	CATIP	Q7Z7H3	BRD9	Homo sapiens	Q9H8M2	Validated Y2H	25416956
Intra	CATIP	Q7Z7H3	MEDAG	Homo sapiens	Q5VYS4	Y2H Array	32296183
Intra	CATIP	Q7Z7H3	MEDAG	Homo sapiens	Q5VYS4	Y2H Prey Pooling	32296183
Intra	CATIP	Q7Z7H3	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	CATIP	Q7Z7H3	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	CATIP	Q7Z7H3	BRD9	Homo sapiens	Q9H8M2-3	Y2H Prey Pooling	32296183
Intra	CATIP	Q7Z7H3	BRD9	Homo sapiens	Q9H8M2-3	Validated Y2H	32296183
Intra	CATIP	Q7Z7H3	BRD9	Homo sapiens	Q9H8M2-3	Y2H Array	32296183
Intra	CATIP	Q7Z7H3	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	CATIP	Q7Z7H3	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	CATIP	Q7Z7H3	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	CATIP	Q7Z7H3	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	CATIP	Q7Z7H3	CEP72	Homo sapiens	Q9P209	Y2H Array	25416956
Intra	CATIP	Q7Z7H3	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	CATIP	Q7Z7H3	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	CATIP	Q7Z7H3	MTUS2	Homo sapiens	Q5JR59	Y2H Prey Pooling	25416956
Intra	CATIP	Q7Z7H3	MTUS2	Homo sapiens	Q5JR59	Y2H Array	25416956
Intra	CATIP	Q7Z7H3	CTNNBL1	Homo sapiens	Q8WYA6	Y2H Prey Pooling	25416956
Intra	CATIP	Q7Z7H3	HESX1	Homo sapiens	Q9UBX0	Y2H Prey Pooling	32296183
Intra	CATIP	Q7Z7H3	HESX1	Homo sapiens	Q9UBX0	Validated Y2H	32296183
Intra	CATIP	Q7Z7H3	HESX1	Homo sapiens	Q9UBX0	Y2H Array	32296183
Intra	CATIP	Q7Z7H3	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	CATIP	Q7Z7H3	KRT31	Homo sapiens	Q15323	Validated Y2H	25416956
Intra	CATIP	Q7Z7H3	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	CATIP	Q7Z7H3	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	25416956
Intra	CATIP	Q7Z7H3	KRT31	Homo sapiens	Q15323	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spermatogenic Failure 54

SPGF54

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Melnick-Needles Syndrome

MNS	Melnick-Needles Osteodysplasty
Osteodysplasty Of Melnick And Needles	Osteochondrodysplasias

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01983	CATIP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CATIP	RGD	RGD:1596071
Mus musculus	CATIP	MGD	MGI:2685062
Bos taurus	CATIP	VGNC	VGNC:26793
Canis familiaris	CATIP	VGNC	VGNC:57375
Felis catus	CATIP	VGNC	VGNC:60392
Macaca mulatta	CATIP	VGNC	VGNC:70624

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