CEP72 - centrosomal protein 72 Gene

Homo sapiens

Gene ID: 55722 | Gene type: protein coding

About CEP72

Cytogenetic location: 5p15.33 Genomic coordinates (GRCh38): 5:612,340-676,616 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 157 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in lung (RPKM 2.7), thyroid (RPKM 2.2) and 25 other tissues.

Summary

The product of this gene is a member of the leucine-rich-repeat (LRR) superfamily of proteins. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. [provided by RefSeq, Jul 2008]

CEP72 Products(1)

mRNA	Protein	Name
NM_018140.4	NP_060610.2	centrosomal protein of 72 kDa

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in centriole replication	IMP IMP: Inferred from mutant phenotype	26297806	GOA
involved in gamma-tubulin complex localization	IMP IMP: Inferred from mutant phenotype	19536135	GOA
involved in regulation of protein localization to centrosome	IMP IMP: Inferred from mutant phenotype	26297806	GOA
involved in spindle organization	IMP IMP: Inferred from mutant phenotype	19536135	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centriolar satellite	IDA IDA: Inferred from direct assay	26297806	GOA
located in centrosome	IDA IDA: Inferred from direct assay	19536135	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CEP72 Protein Structure

LRR_4

0
100
200
300
400
500
600
647 a.a.

Protein Preferred Names

Protein Names

centrosomal protein of 72 kDa

centrosomal protein 72kDa

CEP72 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CEP72	Q9P209	SFRS2	Homo sapiens	Q6NXQ0	Validated Y2H	25416956
Intra	CEP72	Q9P209	CATIP	Homo sapiens	Q7Z7H3	Y2H Prey Pooling	25416956
Intra	CEP72	Q9P209	CATIP	Homo sapiens	Q7Z7H3	Y2H Array	25416956
Intra	CEP72	Q9P209	CATIP	Homo sapiens	Q7Z7H3	Validated Y2H	25416956
Intra	CEP72	Q9P209	KIZ	Homo sapiens	Q2M2Z5	Anti Bait CoIP	19536135
Intra	CEP72	Q9P209	PSMA1	Homo sapiens	P25786	Y2H Array	25416956
Intra	CEP72	Q9P209	PSMA1	Homo sapiens	P25786	Validated Y2H	25416956
Intra	CEP72	Q9P209	PSMA1	Homo sapiens	P25786	Y2H Prey Pooling	25416956
Intra	CEP72	Q9P209	SPATA24	Homo sapiens	Q86W54	Anti Tag CoIP	33961781
Intra	CEP72	Q9P209	SPATA24	Homo sapiens	Q86W54	Anti Tag CoIP	28514442
Intra	CEP72	Q9P209	SPATA24	Homo sapiens	Q86W54	Y2H Array	25416956
Intra	CEP72	Q9P209	SPAG5	Homo sapiens	Q96R06	Anti Bait CoIP	26297806
Intra	CEP72	Q9P209	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	CEP72	Q9P209	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	CEP72	Q9P209	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	CEP72	Q9P209	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	CEP72	Q9P209	FAM90A1	Homo sapiens	Q86YD7	Validated Y2H	25416956
Intra	CEP72	Q9P209	FAM90A1	Homo sapiens	Q86YD7	Y2H Array	25416956
Intra	CEP72	Q9P209	ATXN7	Homo sapiens	O15265	Y2H	21078624
Intra	CEP72	Q9P209	FXR1	Homo sapiens	P51114	Anti Tag CoIP	21653829
Intra	CEP72	Q9P209	FXR1	Homo sapiens	P51114	Y2H Pooling	21653829
Intra	CEP72	Q9P209	PIN4	Homo sapiens	Q9Y237	Validated Y2H	25416956
Intra	CEP72	Q9P209	PIN4	Homo sapiens	Q9Y237	Y2H Array	25416956
Intra	CEP72	Q9P209	LNX1	Homo sapiens	Q8TBB1	Y2H Array	29892012
Intra	CEP72	Q9P209	LNX1	Homo sapiens	Q8TBB1	Y2H Pooling	16189514
Intra	CEP72	Q9P209	PCM1	Homo sapiens	Q15154	Y2H Pooling	19447967
Intra	CEP72	Q9P209	NME7	Homo sapiens	Q9Y5B8	Y2H Array	25416956
Intra	CEP72	Q9P209	NME7	Homo sapiens	Q9Y5B8	Y2H Prey Pooling	25416956
Intra	CEP72	Q9P209	NME7	Homo sapiens	Q9Y5B8	Validated Y2H	25416956
Intra	CEP72	Q9P209	NME7	Homo sapiens	Q9Y5B8	Validated Y2H	32296183
Intra	CEP72	Q9P209	STAMBPL1	Homo sapiens	Q96FJ0	Y2H Prey Pooling	25416956
Intra	CEP72	Q9P209	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
Intra	CEP72	Q9P209	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	CEP72	Q9P209	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Leukemia, Acute Lymphoblastic 3

Leukemia, Acute Lymphoblastic, Susceptibility To, 3	ALL3
Precursor B-Cell Acute Lymphoblastic Leukemia	B-All
Precursor B-Cell Acute Lymphoblastic Leukemia/Lymphoma	Precursor B-Cell Acute Lymphocytic Leukemia
Precursor B-Cell Acute Lymphocytic Leukemia/Lymphoma	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Burkitt Lymphoma	Precursor B-Cell Lymphoblastic Leukemia

Precursor T-Cell Acute Lymphoblastic Leukemia

T-All	Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma
Precursor T-Cell Acute Lymphocytic Leukemia	Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Adult T-Cell Lymphoma/Leukemia

Axonal Neuropathy

Autonomic Peripheral Neuropathy

Peripheral Autonomic Nervous System Diseases

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02522	CEP72 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CEP72	VGNC	VGNC:39136
Rattus norvegicus	CEP72	RGD	RGD:1566336
Macaca mulatta	CEP72	VGNC	VGNC:71099
Felis catus	CEP72	VGNC	VGNC:60782
Mus musculus	CEP72	MGD	MGI:1921720
Bos taurus	CEP72	VGNC	VGNC:27212

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