Prmt8 - protein arginine N-methyltransferase 8 Gene

Mus musculus

Also known as Hrmt1l3; Hrmt1l4

Gene ID: 381813 | Gene type: protein coding

About Prmt8

Chromosome 6: 127,665,974-127,746,435 reverse strand.GRCm39:CM000999.3

This gene has 1 transcript (splice variant), 281 orthologues, 7 paralogues and is associated with 9 phenotypes. Biased expression in cortex adult (RPKM 13.), frontal lobe adult (RPKM 11.1) and 6 other tissues.

Summary

Predicted to enable several functions, including S-adenosyl-L-methionine binding activity; protein homodimerization activity; and protein-arginine N-methyltransferase activity. Predicted to be involved in histone methylation; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine; and protein homooligomerization. Predicted to act upstream of or within methylation. Predicted to be anchored component of the cytoplasmic side of the plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; genitourinary system; heart; and lung. Orthologous to human PRMT8 (protein arginine methyltransferase 8). [provided by Alliance of Genome Resources, Apr 2022]

Prmt8 Products(1)

mRNA	Protein	Name
NM_201371.2	NP_958759.2	protein arginine N-methyltransferase 8

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of modification of postsynaptic actin cytoskeleton	IDA IDA: Inferred from direct assay	32521269	MGI
involved in regulation of modification of postsynaptic actin cytoskeleton	IEP IEP: Inferred from expression pattern	32521269	MGI
involved in regulation of modification of postsynaptic actin cytoskeleton	IMP IMP: Inferred from mutant phenotype	32521269	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prmt8 Protein Structure

AdoMet_MTases

0
100
200
300
394 a.a.

Protein Preferred Names

Protein Names

protein arginine N-methyltransferase 8

HMT1 hnRNP methyltransferase-like 3	heterogeneous nuclear ribonucleoprotein methyltransferase-like 4
heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4	protein arginine N-methyltransferase 4

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-128717	GSK3368715	Inhibitor	/	Phase 1
HY-128717B	GSK3368715 trihydrochloride	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19615	MS023	Inhibitor	99.73%	Unkown
HY-12970	EPZ020411	Inhibitor	98.06%	Unkown
HY-12970A	EPZ020411 hydrochloride	Inhibitor	98.15%	Unkown
HY-19615B	MS023 dihydrochloride	Inhibitor	99.78%	Unkown
HY-100360	MS049	Inhibitor	≥98.0%	Unkown
HY-161334	CARM1-IN-4	Inhibitor	/	Unkown
HY-146810	PRMT4-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prmt8	NCBI	NCBI:56341

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