PRMT8 - protein arginine methyltransferase 8 Gene

Homo sapiens

Also known as HRMT1L3; HRMT1L4

Gene ID: 56341 | Gene type: protein coding

About PRMT8

Cytogenetic location: 12p13.32 Genomic coordinates (GRCh38): 12:3,381,349-3,593,973 (from NCBI)

This gene has 4 transcripts (splice variants), 281 orthologues and 7 paralogues. Biased expression in brain (RPKM 5.7), testis (RPKM 0.8) and 1 other tissue.

Summary

Arginine methylation is a widespread posttranslational modification mediated by arginine methyltransferases, such as PRMT8. Arginine methylation is involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction, protein compartmentalization, and possibly protein translation (Lee et al., 2005 [PubMed 16051612]).[supplied by OMIM, Mar 2008]

PRMT8 Products(9)

mRNA	Protein	Name
NM_001256536.1	NP_001243465.1	protein arginine N-methyltransferase 8 isoform 2
XM_047429157.1	XP_047285113.1	protein arginine N-methyltransferase 8 isoform X3
XM_047429159.1	XP_047285115.1	protein arginine N-methyltransferase 8 isoform X5
XM_017019644.2	XP_016875133.1	protein arginine N-methyltransferase 8 isoform X1
XM_017019645.1	XP_016875134.1	protein arginine N-methyltransferase 8 isoform X2
XM_047429158.1	XP_047285114.1	protein arginine N-methyltransferase 8 isoform X4
NM_001256537.1
NR_046301.1
NM_019854.5	NP_062828.3	protein arginine N-methyltransferase 8 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables S-adenosyl-L-methionine binding	IDA IDA: Inferred from direct assay	26876602	GOA
enables S-adenosylmethionine-dependent methyltransferase activity	IDA IDA: Inferred from direct assay	16051612	GOA
enables enzyme binding	IDA IDA: Inferred from direct assay	16051612	GOA
enables histone H4 methyltransferase activity	IDA IDA: Inferred from direct assay	16051612	GOA
enables identical protein binding	IDA IDA: Inferred from direct assay	26876602	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16051612	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	16051612	GOA
enables protein-arginine omega-N asymmetric methyltransferase activity	IDA IDA: Inferred from direct assay	16051612	GOA
enables protein-arginine omega-N monomethyltransferase activity	IDA IDA: Inferred from direct assay	16051612	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in peptidyl-arginine methylation	IDA IDA: Inferred from direct assay	18320585	GOA
involved in protein homooligomerization	IDA IDA: Inferred from direct assay	26876602	GOA
involved in protein methylation	IMP IMP: Inferred from mutant phenotype	26876602	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	26876602	GOA
NOT located in nucleus	IDA IDA: Inferred from direct assay	16051612	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	16051612	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRMT8 Protein Structure

PrmA

0
100
200
300
394 a.a.

Protein Preferred Names

Protein Names

protein arginine N-methyltransferase 8

HMT1 hnRNP methyltransferase-like 3	arginine methyltransferase 8
heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4	protein arginine N-methyltransferase 4

PRMT8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PRMT8	Q9NR22	SYNCRIP	Homo sapiens	O60506	Y2H Array	19060904
Intra	PRMT8	Q9NR22	SYNCRIP	Homo sapiens	O60506	Y2H	23455924
Intra	PRMT8	Q9NR22	SYNCRIP	Homo sapiens	O60506	Anti Tag CoIP	33961781
Intra	PRMT8	Q9NR22	SYNCRIP	Homo sapiens	O60506	Y2H Pooling	19060904
Intra	PRMT8	Q9NR22	PRMT1	Homo sapiens	Q99873-3	Y2H Array	32296183
Intra	PRMT8	Q9NR22	PRMT1	Homo sapiens	Q99873-3	Y2H Prey Pooling	32296183
Intra	PRMT8	Q9NR22	PRMT1	Homo sapiens	Q99873-3	MAPPIT	32296183
Intra	PRMT8	Q9NR22	PRMT8	Homo sapiens	Q9NR22	Y2H	23455924
Intra	PRMT8	Q9NR22	PRMT8	Homo sapiens	Q9NR22	Y2H Pooling	16189514
Intra	PRMT8	Q9NR22	PRMT8	Homo sapiens	Q9NR22	Y2H Prey Pooling	32296183
Intra	PRMT8	Q9NR22	PRMT8	Homo sapiens	Q9NR22	Y2H Array	19060904
Intra	PRMT8	Q9NR22	PRMT8	Homo sapiens	Q9NR22	Validated Y2H	32296183
Intra	PRMT8	Q9NR22	PRMT8	Homo sapiens	Q9NR22	Y2H Pooling	19060904
Intra	PRMT8	Q9NR22	PRMT8	Homo sapiens	Q9NR22	Y2H Array	32296183
Intra	PRMT8	Q9NR22	PRMT1	Homo sapiens	Q99873	Y2H	23455924
Intra	PRMT8	Q9NR22	PRMT1	Homo sapiens	Q99873	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-128717	GSK3368715	Inhibitor	/	Phase 1
HY-128717B	GSK3368715 trihydrochloride	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19615	MS023	Inhibitor	99.73%	Unkown
HY-12970	EPZ020411	Inhibitor	98.06%	Unkown
HY-12970A	EPZ020411 hydrochloride	Inhibitor	98.15%	Unkown
HY-19615B	MS023 dihydrochloride	Inhibitor	99.78%	Unkown
HY-100360	MS049	Inhibitor	≥98.0%	Unkown
HY-161334	CARM1-IN-4	Inhibitor	/	Unkown
HY-146810	PRMT4-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PRMT8	RGD	RGD:1587677
Mus musculus	PRMT8	MGD	MGI:3043083
Felis catus	PRMT8	VGNC	VGNC:67652
Bos taurus	PRMT8	VGNC	VGNC:33353
Canis familiaris	PRMT8	VGNC	VGNC:45001
Macaca mulatta	PRMT8	VGNC	VGNC:76360

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