REP15 - RAB15 effector protein Gene

Homo sapiens

Also known as RAB15EP

Gene ID: 387849 | Gene type: protein coding

About REP15

Cytogenetic location: 12p11.22 Genomic coordinates (GRCh38): 12:27,696,447-27,697,596 (from NCBI)

This gene has 1 transcript (splice variant) and 93 orthologues.

Summary

The protein encoded by this intronless gene interacts with GTP-bound Rab15 and is involved in recycling of Transferrin Receptor from the endocytic recycling compartment to the cell surface. [provided by RefSeq, Sep 2016]

REP15 Products(1)

mRNA	Protein	Name
NM_001029874.3	NP_001025045.3	rab15 effector protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16195351	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in receptor recycling	IMP IMP: Inferred from mutant phenotype	16195351	GOA
involved in transferrin transport	IDA IDA: Inferred from direct assay	16195351	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endosome membrane	IDA IDA: Inferred from direct assay	16195351	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	16195351	GOA
located in recycling endosome	IDA IDA: Inferred from direct assay	16195351	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

REP15 Protein Structure

Rab15_effector

0
100
200
236 a.a.

Protein Preferred Names

Protein Names

rab15 effector protein

REP15 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	REP15	Q6BDI9	ARID3A	Homo sapiens	Q99856	Validated Y2H	32296183
Intra	REP15	Q6BDI9	EVI5	Homo sapiens	O60447	Y2H Array	32296183
Intra	REP15	Q6BDI9	EVI5	Homo sapiens	O60447	Anti Tag CoIP	33961781
Intra	REP15	Q6BDI9	EVI5	Homo sapiens	O60447	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Eiken Syndrome

Eiken Skeletal Dysplasia	Bone Modeling Defect Of Hands And Feet
EKNS

Pancreatic Acinar Cell Adenocarcinoma

Pancreatic Acinar Cell Carcinoma

Acinar Cell Adenocarcinoma Of The Pancreas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11843	REP15 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	REP15	VGNC	VGNC:33867
Mus musculus	REP15	MGD	MGI:1913782
Rattus norvegicus	REP15	RGD	RGD:1562899
Felis catus	REP15	VGNC	VGNC:64571

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