2. Gene
  3. FEZF1 - FEZ family zinc finger 1 Gene

FEZF1 - FEZ family zinc finger 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FEZ; HH22; ZNF312B

Gene ID: 389549 | Gene type: protein coding

About FEZF1

Cytogenetic location: 7q31.32 Genomic coordinates (GRCh38): 7:122,301,303-122,310,723 (from NCBI)

This gene has 3 transcripts (splice variants), 196 orthologues, 28 paralogues and is associated with 4 phenotypes. Restricted expression toward testis (RPKM 1.2).

Summary

This gene encodes a transcriptional repressor that belongs to the zinc finger double domain protein family. The encoded protein is thought to play a role in the embryonic migration of gonadotropin-releasing hormone neurons into the brain. Mutations in this gene are associated with hypogonadotropic hypogonadism-22 with anosmia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

FEZF1 Products(2)

mRNA Protein Name
NM_001024613.4 NP_001019784.2 fez family zinc finger protein 1 isoform 1
NM_001160264.2 NP_001153736.1 fez family zinc finger protein 1 isoform 2
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FEZF1 Protein Structure

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (274 - 298)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (305 - 326)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (331 - 354)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (358 - 382)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (400 - 423)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 475 a.a.
Protein Preferred Names Protein Names

fez family zinc finger protein 1

zinc finger protein 312B

FEZF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
FEZF1 A0PJY2 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
32296183
Intra
FEZF1 A0PJY2 KRT40 Homo sapiens Q6A162
Validated Y2H
32296183
Intra
FEZF1 A0PJY2 KRT40 Homo sapiens Q6A162
Y2H Array
32296183
Intra
FEZF1 A0PJY2 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
FEZF1 A0PJY2 KRTAP10-8 Homo sapiens P60410
Validated Y2H
32296183
Intra
FEZF1 A0PJY2 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
FEZF1 A0PJY2 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
FEZF1 A0PJY2 KRTAP1-1 Homo sapiens Q07627
Validated Y2H
32296183
Intra
FEZF1 A0PJY2 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
FEZF1 A0PJY2 CYSRT1 Homo sapiens A8MQ03
Validated Y2H
32296183
Intra
FEZF1 A0PJY2 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
FEZF1 A0PJY2 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
FEZF1 A0PJY2 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
FEZF1 A0PJY2 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra
FEZF1 A0PJY2 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
FEZF1 A0PJY2 FHL5 Homo sapiens Q5TD97
Y2H Prey Pooling
32296183
Intra
FEZF1 A0PJY2 FHL5 Homo sapiens Q5TD97
Validated Y2H
32296183
Intra
FEZF1 A0PJY2 FHL5 Homo sapiens Q5TD97
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypogonadotropic Hypogonadism 22 With Or Without Anosmia

HH22

Hypogonadotropic Hypogonadism 22, With Or Without Anosmia

Hypogonadism, Hypogonadotropic, Type 22 With/Without Anosmia
Kallmann Syndrome

Hypogonadism With Anosmia

Kallman'S Syndrome

Anosmic Hypogonadism

Anosmic Idiopathic Hypogonadotropic Hypogonadism

Hypogonadotropic Hypogonadism And Anosmia

Hypogonadotropic Hypogonadism-Anosmia Syndrome

Olfacto-Genital Pathological Sequence

Familial Hypogonadism With Anosmia

Kallman Syndrome

Dysplasia Olfactogenitalis Of De Morsier

Kallmann'S Syndrome

Congenital Hypogonadotropic Hypogonadism With Anosmia
Pancreatic Ductal Adenocarcinoma

Ductal Adenocarcinoma Of The Pancreas
Hypogonadotropic Hypogonadism 7 With Or Without Anosmia

Idiopathic Hypogonadotropic Hypogonadism

HH7

Hypogonadism, Isolated Hypogonadotropic

Ihh

Hypogonadism, Isolated, Hypogonadotropic

Hypogonadotropic Hypogonadism

Isolated Hypogonadotropic Hypogonadism

Hypogonadotropic Hypogonadism 7 Without Anosmia

Congenital Hypogonadotropic Hypogonadism Normosmic

Hh

Klinefelter Syndrome

Isolated Gonadotropin Deficiency
Hypogonadotropic Hypogonadism

Klinefelter Syndrome

Klinefelter'S Syndrome

Xxy Syndrome

Xxy Trisomy

Hypogonadotropism

47, Xxy

Congenital Idiopathic Hypogonadotropic Hypogonadism

Isolated Congenital Gonadotropin Deficiency

47,Xxy Syndrome

47, Xxy Syndrome

Klinefelters Syndrome

Hypogonadism

Klinefelter Syndrome In Males

Klinefelter Syndrome, Unspecified

Klinefelter Syndrome Karyotype 47, Xxy
Hypogonadism
Uterine Inversion

Inversion Of Uterus During Delivery
Myopathy, Myosin Storage, Autosomal Dominant

MSMA

Myopathy, Hyaline Body, Autosomal Dominant

Myopathy With Lysis Of Type I Myofibrils

Autosomal Dominant Hyaline Body Myopathy

Hyaline Body Myopathy Autosomal Dominant
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
Sensorineural Hearing Loss

Sensory Hearing Loss

Sensorineural Deafness

Sensorineural Hearing Loss Disorder

Hearing Loss, Sensorineural

Central Hearing Loss

High Frequency Deafness

High Frequency Hearing Loss

High-Frequency Hearing Loss

Perceptive Deafness

Perceptive Hearing Loss

Perceptive Hearing Loss Or Deafness

Hearing Loss Sensorineural

Deafness Sensorineural

Hearing Loss High-Frequency

Hearing Loss, Central

Hearing Loss, High-Frequency
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04872 FEZF1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus FEZF1 VGNC VGNC:28959
Felis catus FEZF1 VGNC VGNC:80041
Rattus norvegicus FEZF1 RGD RGD:1560480
Macaca mulatta FEZF1 VGNC VGNC:72550
Mus musculus FEZF1 MGD MGI:1920441