RHOG - ras homolog family member G Gene

Homo sapiens

Also known as ARHG

Gene ID: 391 | Gene type: protein coding

About RHOG

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:3,826,978-3,840,959 (from NCBI)

This gene has 4 transcripts (splice variants), 248 orthologues and 22 paralogues. Broad expression in bone marrow (RPKM 74.8), spleen (RPKM 41.3) and 24 other tissues.

Summary

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin Cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X. [provided by RefSeq, Aug 2011]

RHOG Products(1)

mRNA	Protein	Name
NM_001665.4	NP_001656.2	rho-related GTP-binding protein RhoG

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activity	IDA IDA: Inferred from direct assay	12376551	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12879077	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Rac protein signal transduction	IDA IDA: Inferred from direct assay	12376551	GOA
acts upstream of or within Rho protein signal transduction	IDA IDA: Inferred from direct assay	12376551	GOA
acts upstream of or within actin cytoskeleton organization	IDA IDA: Inferred from direct assay	12545154	GOA
involved in activation of GTPase activity	IMP IMP: Inferred from mutant phenotype	20679435	GOA
involved in cell chemotaxis	IMP IMP: Inferred from mutant phenotype	20679435	GOA
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12545154	GOA
involved in positive regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	20679435	GOA
involved in regulation of postsynapse assembly	IDA IDA: Inferred from direct assay	21900250	GOA
involved in regulation of postsynapse assembly	IMP IMP: Inferred from mutant phenotype	21900250	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	21900250	GOA
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	21900250	GOA
is active in postsynapse	IDA IDA: Inferred from direct assay	21900250	GOA
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	21900250	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RHOG Protein Structure

Ras

0
100
191 a.a.

Protein Preferred Names

Protein Names

rho-related GTP-binding protein RhoG

ras homolog gene family, member G (rho G)

RHOG Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RHOG	P84095	UNC13D	Homo sapiens	Q70J99	Pull Down	33513601
Intra	RHOG	P84095	ELMO1	Homo sapiens	Q92556	Anti Tag CoIP	12879077
Intra	RHOG	P84095	ELMO1	Homo sapiens	Q92556	Pull Down	33513601
Intra	RHOG	P84095	ELMO1	Homo sapiens	Q92556	Pull Down	12879077

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Immunodeficiency 73a With Defective Neutrophil Chemotaxis And Leukocytosis

Neutrophil Immunodeficiency Syndrome	IMD73A
Immunodeficiency 73a With Defective Neutrophil Chemotaxix And Leukocytosis	Immunodeficiency, Type 73a, With Defective Neutrophil Chemotaxix And Leukocytosis
Rac 2 Deficiency

Tangier Disease

Analphalipoproteinemia	High Density Lipoprotein Deficiency, Tangier Type
TGD	High Density Lipoprotein Deficiency, Type 1
Hdldt1	Familial High Density Lipoprotein Deficiency
A-Alphalipoprotein Neuropathy	Alpha High Density Lipoprotein Deficiency Disease
Cholesterol Thesaurismosis	Familial High Density Lipoprotein Deficiency Disease
Hdl Lipoprotein Deficiency Disease	Tangier Disease Neuropathy
Familial Alpha-Lipoprotein Deficiency	Familial High-Density Lipoprotein Deficiency 1
Primary Hypoalphalipoproteinemia 1	Analphalipo-Proteinemia
Familial Hypoalphalipo-Proteinemia	Familial Hypoalphalipoproteinemia
Lipoprotein Deficiency Disease, Hdl, Familial	Tangier Hereditary Neuropathy
Atp-Binding Cassette Transporter A1 Deficiency	Hdld1
High Density Lipoprotein Deficiency 1	Tangier Disease, Variant
Hypoalphalipoproteinemia, Familial	Familial Hdl Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11953	RHOG Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RHOG	VGNC	VGNC:101390
Bos taurus	RHOG	VGNC	VGNC:33949
Mus musculus	RHOG	MGD	MGI:1928370
Rattus norvegicus	RHOG	RGD	RGD:621310
Canis familiaris	RHOG	VGNC	VGNC:45560
Felis catus	RHOG	VGNC	VGNC:68107

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