ABLIM1 - actin binding LIM protein 1 Gene

Homo sapiens

Also known as ABLIM; LIMAB1; LIMATIN; abLIM-1

Gene ID: 3983 | Gene type: protein coding

About ABLIM1

Cytogenetic location: 10q25.3 Genomic coordinates (GRCh38): 10:114,431,110-114,801,373 (from NCBI)

This gene has 14 transcripts (splice variants), 132 orthologues and 3 paralogues. Ubiquitous expression in ovary (RPKM 50.7), heart (RPKM 50.1) and 23 other tissues.

Summary

This gene encodes a LIM zinc-binding domain-containing protein that binds to actin filaments and mediates interactions between actin and cytoplasmic targets. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2017]

ABLIM1 Products(26)

mRNA	Protein	Name
NM_001003407.2	NP_001003407.1	actin-binding LIM protein 1 isoform b
NM_001322882.2	NP_001309811.1	actin-binding LIM protein 1 isoform d
NM_001322883.2	NP_001309812.1	actin-binding LIM protein 1 isoform e
NM_001322884.3	NP_001309813.1	actin-binding LIM protein 1 isoform f
NM_001322885.3	NP_001309814.1	actin-binding LIM protein 1 isoform g
NM_001322886.3	NP_001309815.1	actin-binding LIM protein 1 isoform h
NM_001322887.2	NP_001309816.1	actin-binding LIM protein 1 isoform i
NM_001322888.2	NP_001309817.1	actin-binding LIM protein 1 isoform j
NM_001322889.2	NP_001309818.1	actin-binding LIM protein 1 isoform k
NM_001322890.2	NP_001309819.1	actin-binding LIM protein 1 isoform l
NM_001322891.2	NP_001309820.1	actin-binding LIM protein 1 isoform l
NM_001322892.2	NP_001309821.1	actin-binding LIM protein 1 isoform n
NM_001322893.2	NP_001309822.1	actin-binding LIM protein 1 isoform n
NM_001322894.2	NP_001309823.1	actin-binding LIM protein 1 isoform o
NM_001322895.2	NP_001309824.1	actin-binding LIM protein 1 isoform o
NM_001322896.2	NP_001309825.1	actin-binding LIM protein 1 isoform p
NM_001322897.2	NP_001309826.1	actin-binding LIM protein 1 isoform q
NM_001322898.2	NP_001309827.1	actin-binding LIM protein 1 isoform r
NM_001322899.2	NP_001309828.1	actin-binding LIM protein 1 isoform r
NM_001322900.2	NP_001309829.1	actin-binding LIM protein 1 isoform t
NM_001352440.1	NP_001339369.1	actin-binding LIM protein 1 isoform u
NM_001352441.1	NP_001339370.1	actin-binding LIM protein 1 isoform v
NM_001352442.2	NP_001339371.1	actin-binding LIM protein 1 isoform w
NM_001352443.2	NP_001339372.1	actin-binding LIM protein 1 isoform x
NM_002313.7	NP_002304.3	actin-binding LIM protein 1 isoform a
NM_006720.4	NP_006711.3	actin-binding LIM protein 1 isoform s

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15778465	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cilium assembly	IMP IMP: Inferred from mutant phenotype	22684256	GOA
acts upstream of or within lamellipodium assembly	IMP IMP: Inferred from mutant phenotype	22684256	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in lamellipodium	IDA IDA: Inferred from direct assay	22684256	GOA
located in stress fiber	IDA IDA: Inferred from direct assay	22684256	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ABLIM1 Protein Structure

LIM

VHP

0
200
400
600
778 a.a.

Protein Preferred Names

Protein Names

actin-binding LIM protein 1

actin-binding LIM protein family member 1

ABLIM1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ABLIM1	O14639	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	33961781
Intra	ABLIM1	O14639	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	ABLIM1	O14639	SFN	Homo sapiens	P31947	TAP	15778465
Intra	ABLIM1	O14639	LDOC1	Homo sapiens	O95751	Pull Down	16189514
Intra	ABLIM1	O14639	CARD9	Homo sapiens	Q9H257	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spermatogenic Failure, Y-Linked, 2

SPGFY2	Spermatogenic Failure, Nonobstructive, Y-Linked
Y-Linked Spermatogenic Failure 2	Azoospermia, Nonobstructive, Y-Linked
Oligozoospermia, Nonobstructive, Y-Linked	Oligospermia, Nonobstructive, Y-Linked
Spermatogenic Arrest, Y-Linked	Nonobstructive Y-Linked Spermatogenic Failure
Spermatogenic Failure Y-Linked 2	Azoospermia Non-Obstructive Y-Linked
Non-Obstructive Azoospermia And Infertility	Oligospermia Non-Obstructive Y-Linked
Oligozoospermia Non-Obstructive Y-Linked	Spermatogenic Arrest Y-Linked
Spermatogenic Failure Nonobstructive Y-Linked

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00106	ABLIM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ABLIM1	VGNC	VGNC:55931
Felis catus	ABLIM1	VGNC	VGNC:68486
Rattus norvegicus	ABLIM1	RGD	RGD:1565768
Macaca mulatta	ABLIM1	VGNC	VGNC:69587
Canis familiaris	ABLIM1	VGNC	VGNC:37478
Mus musculus	ABLIM1	MGD	MGI:1194500

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