MED11 - mediator complex subunit 11 Gene

Homo sapiens

Also known as HSPC296

Gene ID: 400569 | Gene type: protein coding

About MED11

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,731,428-4,733,607 (from NCBI)

This gene has 4 transcripts (splice variants) and 181 orthologues. Ubiquitous expression in kidney (RPKM 9.3), spleen (RPKM 8.7) and 25 other tissues.

Summary

MED11 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]

MED11 Products(2)

mRNA	Protein	Name
NM_001001683.4	NP_001001683.1	mediator of RNA polymerase II transcription subunit 11 isoform a
NM_001305000.2	NP_001291929.1	mediator of RNA polymerase II transcription subunit 11 isoform b

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12584197	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of core mediator complex	IPI IPI: Inferred from physical interaction	24882805	GOA
part of mediator complex	IDA IDA: Inferred from direct assay	14638676	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24882805	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED11 Protein Structure

Med11

0
100
117 a.a.

Protein Preferred Names

Protein Names

mediator of RNA polymerase II transcription subunit 11

mediator of RNA polymerase II transcription, subunit 11 homolog

MED11 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MED11	Q9P086	MED8	Homo sapiens	Q96G25	Crosslink	30021884
Intra	MED11	Q9P086	MED8	Homo sapiens	Q96G25	Anti Tag CoIP	35271311
Intra	MED11	Q9P086	MED22	Homo sapiens	Q15528	Anti Tag CoIP	12584197
Intra	MED11	Q9P086	MED22	Homo sapiens	Q15528	Pull Down	12584197
Intra	MED11	Q9P086	MED22	Homo sapiens	Q15528	Anti Tag CoIP	35271311
Intra	MED11	Q9P086	NME7	Homo sapiens	Q9Y5B8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cornelia De Lange Syndrome 4 With Or Without Midline Brain Defects

Cornelia De Lange Syndrome 4	CDLS4
Cornelia De Lange Syndrome, Type 4

Luminal Breast Carcinoma A

Breast Tumor Luminal	Luminal A Breast Carcinoma
Luminal Breast Cancer

Trichorhinophalangeal Syndrome, Type Ii

Langer-Giedion Syndrome	Lgs
Trichorhinophalangeal Syndrome Type Ii	Trichorhinophalangeal Syndrome Type 2
TRPS2	Monosomy 8q24.1
Chromosome 8q24.1 Deletion Syndrome	Deletion 8q24.1
Giedion-Langer Syndrome	Trichorhinophalangeal Dysplasia Type Ii
Langer Giedion Syndrome	Trps 2
Tricho-Rhino-Phalangeal Syndrome Type Ii	Trichorhinophalangeal Syndrome With Exostosis
Trps Ii	Tricho-Rhino-Phalangeal Syndrome 2
8q24.1 Microdeletion Syndrome	8q24.1 Deletion Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08280	MED11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MED11	RGD	RGD:1563202
Felis catus	MED11	VGNC	VGNC:99222
Bos taurus	MED11	VGNC	VGNC:31348
Mus musculus	MED11	MGD	MGI:1913422
Macaca mulatta	MED11	VGNC	VGNC:74633
Canis familiaris	MED11	VGNC	VGNC:43119

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