MED8 - mediator complex subunit 8 Gene

Homo sapiens

Also known as ARC32

Gene ID: 112950 | Gene type: protein coding

About MED8

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:43,383,917-43,389,800 (from NCBI)

This gene has 5 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in thyroid (RPKM 12.7), placenta (RPKM 11.6) and 25 other tissues.

Summary

This gene encodes a protein component of the mediator complex, which aids in transcriptional activation through interaction with RNA polymerase II and gene-specific transcription factors. The encoded protein may also function in ubiquitin ligation and protein degradation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]

MED8 Products(3)

mRNA	Protein	Name
NM_001001653.3	NP_001001653.1	mediator of RNA polymerase II transcription subunit 8 isoform 1
NM_052877.5	NP_443109.2	mediator of RNA polymerase II transcription subunit 8 isoform 3
NM_201542.5	NP_963836.2	mediator of RNA polymerase II transcription subunit 8 isoform 4

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12149480	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of core mediator complex	IPI IPI: Inferred from physical interaction	24882805	GOA
part of mediator complex	IDA IDA: Inferred from direct assay	14638676	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24882805	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED8 Protein Structure

Med8

0
100
200
268 a.a.

Protein Preferred Names

Protein Names

mediator of RNA polymerase II transcription subunit 8

activator-recruited cofactor 32 kDa component

Related Diseases

Diseases

Alias

Phlebotomus Fever

Pappataci Fever	Sandfly Fever
Sandfly-Borne Phleboviral Disease	Sandfly-Borne Arboviral Fever
Sandfly-Borne Bunyavirus Fever	Three Day Fever
Chitral Fever	Italy Summer Grippe
Italy Summer Grippe Influenza

La Crosse Encephalitis

California Encephalitis	California Virus Encephalitis
Neuroinvasive California Encephalitis Virus Infection	Californian Encephalitis
Encephalitis, California	California Meningoencephalitis
California Encephalitis Virus Infection	California Encephalitis Virus Infection Neuroinvasive Disease
California Meningoencephalitis Virus Disease	California Serogroup Virus Neuroinvasive Disease
California Viral Encephalitis	Ce - [California Encephalitis]
Lac - [La Crosse Encephalitis]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08306	MED8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MED8	VGNC	VGNC:63443
Rattus norvegicus	MED8	RGD	RGD:1305552
Mus musculus	MED8	MGD	MGI:1915269
Macaca mulatta	MED8	VGNC	VGNC:74540

Name
Email *

	Sorry, but the email address you supplied was invalid.