LMO7 - LIM domain 7 Gene

Homo sapiens

Also known as LOMP; FBX20; LMO7b; FBXO20

Gene ID: 4008 | Gene type: protein coding

About LMO7

Cytogenetic location: 13q22.2 Genomic coordinates (GRCh38): 13:75,620,434-75,859,870 (from NCBI)

This gene has 27 transcripts (splice variants), 326 orthologues and 1 paralogue. Broad expression in lung (RPKM 43.5), esophagus (RPKM 32.9) and 17 other tissues.

Summary

This gene encodes a protein containing a calponin homology (CH) domain, a PDZ domain, and a LIM domain, and may be involved in protein-protein interactions. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, however, the full-length nature of some variants is not known. [provided by RefSeq, Jan 2009]

LMO7 Products(8)

mRNA	Protein	Name
NM_001306080.2	NP_001293009.1	LIM domain only protein 7 isoform 3
NM_001330583.1	NP_001317512.1	LIM domain only protein 7 isoform 4
NM_001366632.2	NP_001353561.1	LIM domain only protein 7 isoform 2
NM_001366633.2	NP_001353562.1	LIM domain only protein 7 isoform 5
NM_001366634.2	NP_001353563.1	LIM domain only protein 7 isoform 6
NM_001366636.2	NP_001353565.1	LIM domain only protein 7 isoform 6
NM_005358.5	NP_005349.3	LIM domain only protein 7 isoform 1
NM_015842.2	NP_056667.2	LIM domain only protein 7 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15161933	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17067998	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	17067998	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17067998	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	17067998	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17067998	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LMO7 Protein Structure

PDZ

0
300
600
900
1200
1385 a.a.

Protein Preferred Names

Protein Names

LIM domain only protein 7

F-box only protein 20

Related Diseases

Diseases

Alias

Townes-Brocks Syndrome

Townes Syndrome	Renal-Ear-Anal-Radial Syndrome
Anus, Imperforate, With Hand, Foot And Ear Anomalies	Imperforate Anus-Hand, Foot And Ear Anomalies Syndrome
Rear Syndrome	Sensorineural Deafness With Imperforate Anus And Hypoplastic Thumbs
Tbs	Deafness, Sensorineural, With Imperforate Anus And Hypoplastic Thumbs
Imperforate Anus With Hand, Foot And Ear Anomalies	Anal-Ear-Renal-Radial Malformation Syndrome
Deafness-Imperforate Anus-Hypoplastic Thumbs Syndrome	Imperforate Anus-Hand And Foot Anomalies Syndrome
Sensorineural Deafness-Imperforate Anus-Hypoplastic Thumbs Syndrome	Sensorineural Hearing Loss With Imperforate Anus And Hypoplastic Thumbs

Hyperalphalipoproteinemia 1

Hyperalphalipoproteinemia	HALP1
Cetp Deficiency	Cholesterol-Ester Transfer Protein Deficiency
Familial Hyperalphalipoproteinemia	Cholesteryl Ester Transfer Protein Deficiency
Cept Deficiency	Cholesterol Ester Transfer Protein Deficiency

Cardiomyopathy, Dilated, 1dd

Dilated Cardiomyopathy 1dd	CMD1DD
Cardiomyopathy, Dilated 1dd	Cardiomyopathy, Dilated, Type 1dd

Astigmatism

Emery-Dreifuss Muscular Dystrophy 1, X-Linked

EDMD1	Emd1
Muscular Dystrophy, Tardive, Dreifuss-Emery Type, With Contractures	X-Linked Emery-Dreifuss Muscular Dystrophy 1
Humeroperoneal Neuromuscular Disease	X-Linked Emery-Dreifuss Muscular Dystrophy
Scapuloperoneal Syndrome, X-Linked, Formerly	Humeroperoneal Neuromuscular Disease, Formerly
Scapuloperoneal Syndrome, X-Linked	Muscular Dystrophy Tardive Dreifuss-Emery Type With Contractures
Scapuloperoneal Syndrome X-Linked	X-Edmd
Dystrophy, Muscular, Emery-Dreifuss, Type 1, X-Linked

Emery-Dreifuss Muscular Dystrophy

Edmd	Emery-Dreifuss Syndrome
Muscular Dystrophy, Emery-Dreifuss	Humeroperoneal Neuromuscular Disease
Muscular Dystrophy, Tardive, Dreifuss-Emery Type, With Contractures	Scapuloperoneal Syndrome, X-Linked
Benign Scapuloperoneal Muscular Dystrophy With Early Contractures	Muscular Dystrophy, Emery-Dreifuss Type
Muscular Dystrophy Emery-Dreifuss	Dystrophy, Muscular, Emery-Dreifuss
Emd - [Emery-Dreifuss Muscular Dystrophy]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07721	LMO7 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LMO7	RGD	RGD:1302984
Felis catus	LMO7	VGNC	VGNC:68073
Mus musculus	LMO7	MGD	MGI:1353586
Bos taurus	LMO7	VGNC	VGNC:30937
Macaca mulatta	LMO7	VGNC	VGNC:74433
Canis familiaris	LMO7	VGNC	VGNC:42725

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