2. Gene
  3. ARL3 - ADP ribosylation factor like GTPase 3 Gene

ARL3 - ADP ribosylation factor like GTPase 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RP83; ARFL3; JBTS35

Gene ID: 403 | Gene type: protein coding

About ARL3

Cytogenetic location: 10q24.32 Genomic coordinates (GRCh38): 10:102,673,731-102,714,397 (from NCBI)

This gene has 1 transcript (splice variant), 274 orthologues, 30 paralogues and is associated with 6 phenotypes. Ubiquitous expression in brain (RPKM 13.2), kidney (RPKM 7.9) and 24 other tissues.

Summary

ADP-ribosylation factor-like 3 is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL3 binds guanine nucleotides but lacks ADP-ribosylation factor activity. [provided by RefSeq, Jul 2008]

ARL3 Products(1)

mRNA Protein Name
NM_004311.4 NP_004302.1 ADP-ribosylation factor-like protein 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables GDP binding IDA
IDA: Inferred from direct assay
18588884 GOA
enables GTP binding IDA
IDA: Inferred from direct assay
18588884 GOA
enables microtubule binding IDA
IDA: Inferred from direct assay
12417528 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11847227 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cilium assembly IMP
IMP: Inferred from mutant phenotype
22085962 GOA
involved in mitotic cytokinesis IMP
IMP: Inferred from mutant phenotype
16525022 GOA
acts upstream of or within post-Golgi vesicle-mediated transport IMP
IMP: Inferred from mutant phenotype
20106869 GOA
involved in protein localization to cilium IMP
IMP: Inferred from mutant phenotype
30269812 GOA
involved in small GTPase-mediated signal transduction IDA
IDA: Inferred from direct assay
22085962 GOA
Cellular Component GO Annotation Evidence Reference Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
16525022 GOA
located in centrosome IDA
IDA: Inferred from direct assay
16525022 GOA
NOT located in cilium IDA
IDA: Inferred from direct assay
17646400 GOA
located in cilium IDA
IDA: Inferred from direct assay
16525022 GOA
located in cytoplasmic microtubule IDA
IDA: Inferred from direct assay
12417528 GOA
located in midbody IDA
IDA: Inferred from direct assay
16525022 GOA
located in nucleus IDA
IDA: Inferred from direct assay
16525022 GOA
located in photoreceptor connecting cilium IDA
IDA: Inferred from direct assay
12417528 GOA
located in spindle microtubule IDA
IDA: Inferred from direct assay
16525022 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARL3 Protein Structure

Arf

Arf: ADP-ribosylation factor family (4 - 176)

  • 0
  • 100
  • 182 a.a.
Protein Preferred Names Protein Names

ADP-ribosylation factor-like protein 3

ADP-ribosylation factor-like 3

Related Diseases

Diseases Alias
Joubert Syndrome 35

JBTS35

Joubert Syndrome, Type 35
Retinitis Pigmentosa 83

RP83

Retinitis Pigmentosa, Type 83
Progressive Cone Dystrophy

Cone Dystrophy

Cone Dystrophy Progressive
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Joubert Syndrome 1

Joubert Syndrome

Jbts

Cerebellooculorenal Syndrome 1

JBTS1

Joubert-Boltshauser Syndrome

Cerebelloparenchymal Disorder Iv

Cpd4

Cors1

Joubert Syndrome And Related Disorders

Jsrd

Familial Aplasia Of The Vermis

Joubert Syndrome Related Disorders

Js

Cerebellar Vermis Agenesis

Cerebelloparenchymal Disorder 4

Agenesis Of Cerebellar Vermis

Cerebello-Oculo-Renal Syndrome

Cors

Joubert-Bolthauser Syndrome

Cpd Iv

Classic Joubert Syndrome

Joubert Syndrome Type A

Pure Joubert Syndrome

Cerebello-Oculo-Renal Syndrome 1

Joubert Syndrome-1

Joubert Syndrome, Type 1

Joubert'S Syndrome
Cone-Rod Dystrophy 2

Cone-Rod Dystrophy

CORD2

Cone-Rod Retinal Dystrophy

Rcrd2

Cone-Rod Retinal Dystrophy 2

Crd2

Cord

Crd

Retinal Cone-Rod Dystrophy

Cone-Rod Retinal Dystrophy-2

Retinal Cone-Rod Dystrophy 2

Tapetoretinal Degeneration

Cone-Rod Degeneration

Cone Rod Dystrophy

Dystrophy, Cone-Rod

Dystrophy, Cone-Rod, Type 2

Retinitis Pigmentosa

Retinitis Pigmentosa 2

Progressive Cone-Rod Dystrophy
Retinitis Pigmentosa 2

RP2

X-Linked Retinitis Pigmentosa 2

Xlrp2

Xlrp-2

Retinitis Pigmentosa-2

Retinitis Pigmentosa, Type 2
Joubert Syndrome 22

JBTS22

Joubert Syndrome, Type 22
Bardet-Biedl Syndrome

Bbs

Biedl-Bardet Syndrome
Renal-Hepatic-Pancreatic Dysplasia

Ivemark'S Syndrome

Ivemark Ii Syndrome

Renohepaticopancreatic Dysplasia
Nephronophthisis 2

NPHP2

Nph2

Nephronophthisis 2, Infantile

Infantile Nephronophthisis 2

Infantile Nephronophthisis

Nephronophthisis, Type 2
Cone-Rod Dystrophy 16

Retinitis Pigmentosa 64

Retinal Dystrophy With Early Macular Involvement

CORD16

RP64
Nephronophthisis

Medullary Cystic Disease

Medullary Cystic Kidney

Nph

Nphp

Kidney Disease, Cystic, Medullary
Cone Dystrophy

Retinal Cone Dystrophy

Dystrophy, Cone

Cone Dystrophy 3
Meckel Syndrome, Type 1

Meckel-Gruber Syndrome

Meckel Syndrome

Dysencephalia Splanchnocystica

Meckel Syndrome 1

MKS1

Mks

Gruber Syndrome

Meckel-Gruber Syndrome, Type 1

Mes

Dysencephalia Splachnocystica

Meckel Gruber Syndrome

Meckel Syndrome Type 1
Visceral Heterotaxy

Situs Ambiguus

Heterotaxia

Heterotaxy Syndrome

Heterotaxy

Lateralization Defect

Situs Ambiguous

Left Isomerism

Htx

Ivemark Syndrome

Right Isomerism

Situs Ambiguus Viscerum

Incomplete Situs Inversus

Partial Situs Inversus

Heterotaxy, Visceral

Asplenia Syndrome

Bilateral Left-Sidedness

Polysplenia Syndrome

Moller Syndrome
Leber Plus Disease

Leber Congenital Amaurosis

Lca

Leber'S Amaurosis

Leber'S Disease

Amaurosis Congenita Of Leber

Amaurosis Congenita Of Leber, Type 1

Lhon Plus Disease

Congenital Absence Of The Rods And Cones

Congenital Retinal Blindness

Crb

Congenital Amaurosis Of Retinal Origin

Leber'S Congenital Amaurosis

Leber Congenital Amaurosis 1

Leber'S Congenital Tapetoretinal Degeneration

Leber'S Congenital Tapetoretinal Dysplasia

Lca1

Leber Congenital Amaurosis Type 1

Retinal Blindness, Congenital

Amaurosis, Leber Congenital

Dysgenesis Neuroepithelialis Retinae

Hereditary Epithelial Dysplasia Of Retina

Hereditary Retinal Aplasia

Heredoretinopathia Congenitalis

Leber Abiotrophy

Leber Congenital Tapetoretinal Degeneration

Lebers Congenital Amaurosis

Optic Atrophy, Hereditary, Leber
Fundus Dystrophy

Retinal Dystrophy

Retinal Dystrophies

Dystrophy, Retinal
Polycystic Kidney Disease

Polycystic Kidney Diseases

Pkd

Polycystic Renal Disease

Kidney Disease, Polycystic

Polycystic Kidney, Autosomal Dominant
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00987 ARL3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ARL3 MGD MGI:1929699
Canis familiaris ARL3 VGNC VGNC:38111
Bos taurus ARL3 VGNC VGNC:26143
Felis catus ARL3 VGNC VGNC:68209
Rattus norvegicus ARL3 RGD RGD:69327