APOBEC4 - apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4 Gene

Homo sapiens

Also known as C1orf169

Gene ID: 403314 | Gene type: protein coding

About APOBEC4

Cytogenetic location: 1q25.3 Genomic coordinates (GRCh38): 1:183,646,275-183,653,316 (from NCBI)

This gene has 2 transcripts (splice variants) and 97 orthologues. Restricted expression toward testis (RPKM 6.1).

Summary

This gene encodes a member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases, which convert cytidine to uridine. Other AID/APOBEC family members are involved in mRNA editing, somatic hypermutation and recombination of immunoglobulin genes, and innate immunity to retroviral Infection. [provided by RefSeq, Jul 2008]

APOBEC4 Products(1)

mRNA	Protein	Name
NM_203454.3	NP_982279.1	putative C->U-editing enzyme APOBEC-4

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APOBEC4 Protein Structure

APOBEC_N

0
100
200
300
367 a.a.

Protein Preferred Names

Protein Names

putative C->U-editing enzyme APOBEC-4

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)

APOBEC4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	APOBEC4	Q8WW27	RAN	Homo sapiens	P62826	Validated Y2H	32814053
Intra	APOBEC4	Q8WW27	RAN	Homo sapiens	P62826	Y2H Array	32814053
Intra	APOBEC4	Q8WW27	RAN	Homo sapiens	P62826	Y2H Pooling	32814053
Intra	APOBEC4	Q8WW27	CASP6	Homo sapiens	P55212	Y2H Array	32814053
Intra	APOBEC4	Q8WW27	CASP6	Homo sapiens	P55212	Y2H Pooling	32814053
Intra	APOBEC4	Q8WW27	CASP6	Homo sapiens	P55212	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Immunodeficiency With Hyper-Igm, Type 2

HIGM2	Hyper-Igm Syndrome Type 2
Hyper-Igm Syndrome 2	Immunodeficiency With Hyper-Igm Type 2
Activation-Induced Cytidine Deaminase Deficiency	Aid Deficiency
Immunodeficiency With Hyper Igm Type 2	Hyper Igm Syndrome 2
Immunodeficiency With Hyper-Igm 2	Hyper-Igm Immunodeficiency Type 2
Immunodeficiency, With Hyper Igm, Type 2	Hyper-Igm Immunodeficiency Syndrome, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00842	APOBEC4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	APOBEC4	VGNC	VGNC:69936
Mus musculus	APOBEC4	MGD	MGI:1918531
Canis familiaris	APOBEC4	VGNC	VGNC:37997
Felis catus	APOBEC4	VGNC	VGNC:59854
Bos taurus	APOBEC4	VGNC	VGNC:26029
Rattus norvegicus	APOBEC4	RGD	RGD:1560256

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