2. Gene
  3. LRPAP1 - LDL receptor related protein associated protein 1 Gene

LRPAP1 - LDL receptor related protein associated protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RAP; MRAP; A2RAP; HBP44; MYP23; A2MRAP; alpha-2-MRAP

Gene ID: 4043 | Gene type: protein coding

About LRPAP1

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:3,503,612-3,532,422 (from NCBI)

This gene has 6 transcripts (splice variants), 192 orthologues and is associated with 3 phenotypes. Ubiquitous expression in kidney (RPKM 14.2), placenta (RPKM 12.8) and 25 other tissues.

Summary

This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

LRPAP1 Products(1)

mRNA Protein Name
NM_002337.4 NP_002328.1 alpha-2-macroglobulin receptor-associated protein precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables low-density lipoprotein particle receptor binding IDA
IDA: Inferred from direct assay
7774585 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
8083232 GOA
enables receptor antagonist activity IDA
IDA: Inferred from direct assay
8083232 GOA
enables receptor ligand activity IDA
IDA: Inferred from direct assay
11294867 GOA
enables very-low-density lipoprotein particle receptor binding IPI
IPI: Inferred from physical interaction
8083232 GOA
Biological Process GO Annotation Evidence Reference Source
involved in amyloid-beta clearance by transcytosis IMP
IMP: Inferred from mutant phenotype
26005850 GOA
involved in negative regulation of amyloid-beta clearance IGI
IGI: Inferred from genetic interaction
19098903 GOA
involved in negative regulation of protein binding IDA
IDA: Inferred from direct assay
8083232 GOA
involved in negative regulation of receptor internalization IGI
IGI: Inferred from genetic interaction
23386614 GOA
involved in negative regulation of very-low-density lipoprotein particle clearance IDA
IDA: Inferred from direct assay
8083232 GOA
involved in regulation of receptor-mediated endocytosis IDA
IDA: Inferred from direct assay
7774585 GOA
involved in signal transduction IDA
IDA: Inferred from direct assay
11294867 GOA
Cellular Component GO Annotation Evidence Reference Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
7774585 GOA
located in cis-Golgi network IDA
IDA: Inferred from direct assay
7774585 GOA
located in endoplasmic reticulum-Golgi intermediate compartment IDA
IDA: Inferred from direct assay
7774585 GOA
located in endosome IDA
IDA: Inferred from direct assay
7774585 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
16263759 GOA
located in rough endoplasmic reticulum lumen IDA
IDA: Inferred from direct assay
7774585 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRPAP1 Protein Structure

Alpha-2-MRAP_N

Alpha-2-MRAP_N: Alpha-2-macroglobulin RAP, N-terminal domain (15 - 133)

Alpha-2-MRAP_C

Alpha-2-MRAP_C: Alpha-2-macroglobulin RAP, C-terminal domain (145 - 357)

  • 0
  • 100
  • 200
  • 300
  • 357 a.a.
Protein Preferred Names Protein Names

alpha-2-macroglobulin receptor-associated protein

39 kDa receptor-associated protein

Recombinant LRPAP1 Proteins

Cat. No. Product Name Accession Purity
HY-P76478 LRPAP1 Protein, Human (HEK293, His) P30533 (Y35-L357) ≥95%

Related Diseases

Diseases Alias
Myopia 23, Autosomal Recessive

MYP23

Myopia, Type 23, Autosomal Recessive
Rare Isolated Myopia
Myopia

Near-Sightedness

Short-Sightedness

Nearsightedness

Nearsighted

Near Vision

Close Sighted

Myopic

Short-Sighted

Near Sighted
Refractive Error

Refractive Errors
Axenfeld-Rieger Syndrome, Type 2

Axenfeld-Rieger Syndrome Type 2

RIEG2

Rieger Syndrome, Type 2

Rieger Syndrome Type 2

Rieger Syndrome 2
Glomerulonephritis

Bright'S Disease
Membranous Nephropathy

Membranous Glomerulonephritis

Glomerulonephritis, Membranous

Idiopathic Membranous Nephropathy

Idiopathic Membranous Glomerulonephritis

MBNP

Membranous Nephropathy, Susceptibility To

Extramembranous Glomerulonephritis

Mgn

Membranous Gn

Primary Membranous Glomerulonephritis

Primary Membranous Nephropathy

Nephropathy Membranous
Lissencephaly

Pachygyria

Broad Gyri Of Cerebrum

Large Gyri Of Cerebrum

Macrogyria
Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P0009A Cetrorelix Acetate Antagonist 99.87% Unkown
HY-P0009B Cetrorelix diacetate Antagonist / Unkown
Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07803 LRPAP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LRPAP1 RGD RGD:620700
Canis familiaris LRPAP1 VGNC VGNC:42780
Felis catus LRPAP1 VGNC VGNC:68093
Mus musculus LRPAP1 MGD MGI:96829
Bos taurus LRPAP1 VGNC VGNC:30995
Macaca mulatta LRPAP1 VGNC VGNC:74448
Others LRPAP1 NCBI