LSAMP - limbic system associated membrane protein Gene

Homo sapiens

Also known as LAMP; IGLON3

Gene ID: 4045 | Gene type: protein coding

About LSAMP

Cytogenetic location: 3q13.31 Genomic coordinates (GRCh38): 3:115,802,374-116,445,487 (from NCBI)

This gene has 7 transcripts (splice variants), 219 orthologues and 5 paralogues. Biased expression in brain (RPKM 19.9), prostate (RPKM 5.4) and 9 other tissues.

Summary

This gene encodes a member of the immunoglobulin LAMP, OBCAM and neurotrimin (IgLON) family of proteins. The encoded preproprotein is proteolytically processed to generate a neuronal surface glycoprotein. This protein may act as a selective homophilic adhesion molecule during axon guidance and neuronal growth in the developing limbic system. The encoded protein may also function as a tumor suppressor and may play a role in neuropsychiatric disorders. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

LSAMP Products(2)

mRNA	Protein	Name
NM_001318915.2	NP_001305844.1	limbic system-associated membrane protein isoform 2 precursor
NM_002338.5	NP_002329.2	limbic system-associated membrane protein isoform 1 preproprotein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21982860	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LSAMP Protein Structure

I-set

0
100
200
300
338 a.a.

Protein Preferred Names

Protein Names

limbic system-associated membrane protein

IgLON family member 3

LSAMP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LSAMP	Q13449	CENPV	Homo sapiens	Q7Z7K6	Y2H Pooling	32814053
Intra	LSAMP	Q13449	CENPV	Homo sapiens	Q7Z7K6	Validated Y2H	32814053
Intra	LSAMP	Q13449	CENPV	Homo sapiens	Q7Z7K6	Y2H Array	32814053
Intra	LSAMP	Q13449	THAP3	Homo sapiens	Q8WTV1	Y2H Array	32814053
Intra	LSAMP	Q13449	THAP3	Homo sapiens	Q8WTV1	Y2H Pooling	32814053
Intra	LSAMP	Q13449	THAP3	Homo sapiens	Q8WTV1	Validated Y2H	32814053
Intra	LSAMP	Q13449	NTM	Homo sapiens	Q9P121	Protein Array	21982860
Intra	LSAMP	Q13449	METTL27	Homo sapiens	Q8N6F8	Validated Y2H	32814053
Intra	LSAMP	Q13449	METTL27	Homo sapiens	Q8N6F8	Y2H Array	32814053
Intra	LSAMP	Q13449	METTL27	Homo sapiens	Q8N6F8	Y2H Pooling	32814053
Intra	LSAMP	Q13449	BECN1	Homo sapiens	Q14457	Validated Y2H	32814053
Intra	LSAMP	Q13449	BECN1	Homo sapiens	Q14457	Y2H Array	32814053
Intra	LSAMP	Q13449	BECN1	Homo sapiens	Q14457	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LSAMP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70414	LSAMP Protein, Human (HEK293, His)	Q13449 (V29-N315)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07850	LSAMP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LSAMP	VGNC	VGNC:68095
Rattus norvegicus	LSAMP	RGD	RGD:71102
Canis familiaris	LSAMP	VGNC	VGNC:42836
Bos taurus	LSAMP	VGNC	VGNC:106809
Macaca mulatta	LSAMP	VGNC	VGNC:74450
Mus musculus	LSAMP	MGD	MGI:1261760
Others	LSAMP	NCBI

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