LY6E - lymphocyte antigen 6 family member E Gene

Homo sapiens

Also known as RIGE; SCA2; RIG-E; SCA-2; TSA-1

Gene ID: 4061 | Gene type: protein coding

About LY6E

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:143,018,529-143,022,409 (from NCBI)

This gene has 15 transcripts (splice variants), 1 gene allele, 148 orthologues and 2 paralogues. Ubiquitous expression in liver (RPKM 110.6), spleen (RPKM 88.2) and 24 other tissues.

Summary

This gene belongs to the human Ly6 gene family and encodes a glycosylphosphatidyl-inositol (GPI)-anchored cell surface protein. The protein plays an important role in T cell physiology, oncogenesis and immunological regulation. The protein is also involved in modulation of viral Infection by coronaviruses, SARS-CoV, MERS-CoV and SARS-CoV-2. [provided by RefSeq, Aug 2021]

LY6E Products(2)

mRNA	Protein	Name
NM_001127213.2	NP_001120685.1	lymphocyte antigen 6E precursor
NM_002346.3	NP_002337.1	lymphocyte antigen 6E precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of viral entry into host cell	IDA IDA: Inferred from direct assay	32641482	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LY6E Protein Structure

UPAR_LY6

0
100
131 a.a.

Protein Preferred Names

Protein Names

lymphocyte antigen 6E

ly-6E

LY6E Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LY6E	Q16553	TMEM140	Homo sapiens	Q9NV12	Validated Y2H	32296183
Intra	LY6E	Q16553	MFSD6	Homo sapiens	Q6ZSS7	Validated Y2H	32296183
Intra	LY6E	Q16553	TMEM19	Homo sapiens	Q96HH6	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LY6E Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71539	Lymphocyte antigen 6E/LY6E Protein, Human (His-SUMO)	Q16553 (L21-S101)	≥95%

Related Diseases

Diseases

Alias

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Hyperpigmentation With Or Without Hypopigmentation, Familial Progressive

FPHH	Melanosis Universalis Hereditaria
Muh	Familial Progressive Hyperpigmentation With Or Without Hypopigmentation
Hyperpigmentation, Familial Progressive, 2, Formerly	Fph2, Formerly
Hyperpigmentation With Or Without Hypopigmentation	Familial Progressive Hyper- And Hypopigmentation
Hyperpigmentation, Familial Progressive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07897	LY6E Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	LY6E	VGNC	VGNC:42873
Rattus norvegicus	LY6E	RGD	RGD:1565342
Felis catus	LY6E	VGNC	VGNC:81668
Bos taurus	LY6E	VGNC	VGNC:31089
Mus musculus	LY6E	MGD	MGI:106651
Others	LY6E	NCBI

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