NOMO3 - NODAL modulator 3 Gene

Homo sapiens

Also known as Nomo

Gene ID: 408050 | Gene type: protein coding

About NOMO3

Cytogenetic location: 16p13.11 Genomic coordinates (GRCh38): 16:16,232,528-16,294,811 (from NCBI)

This gene has 30 transcripts (splice variants), 1 gene allele, 201 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 58.4), heart (RPKM 50.4) and 25 other tissues.

Summary

This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a duplicated region on the short arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum. [provided by RefSeq, Jul 2008]

NOMO3 Products(1)

mRNA	Protein	Name
NM_001004067.4	NP_001004067.1	nodal modulator 3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22046132	GOA
enables ribosome binding	IDA IDA: Inferred from direct assay	32820719	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in multi-pass transmembrane protein insertion into ER membrane	IDA IDA: Inferred from direct assay	36261522	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of multi-pass translocon complex	IDA IDA: Inferred from direct assay	36261522	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOMO3 Protein Structure

CarboxypepD_reg

0
200
400
600
800
1000
1222 a.a.

Protein Preferred Names

Protein Names

nodal modulator 3

pM5 protein 3

NOMO3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	NOMO3	P69849	P0C6X7-PRO_0000037315	Human SARS coronavirus	P0C6X7-PRO_0000037315	Lumier	22046132
Cross	NOMO3	P69849	P0C6X7-PRO_0000037315	Human SARS coronavirus	P0C6X7-PRO_0000037315	Y2H Pooling	22046132
Intra	NOMO3	P69849	GET4	Homo sapiens	Q7L5D6	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pseudoxanthoma Elasticum

PXE	Gronblad-Strandberg Syndrome
Pseudoxanthoma Elasticum, Modifier Of Severity Of	Gronblad-Strandberg-Touraine Syndrome
Gronblad Strandberg Syndrome	Groenblad-Strandberg Syndrome
Nevus Elasticus	Pxe - [Pseudoxanthoma Elasticum]

Superficial Urinary Bladder Cancer

Superficial Urinary Bladder Carcinoma

Carcinoma Of Urinary Bladder, Superficial

Supraglottis Cancer

Malignant Tumor Of Supraglottis	Supraglottis
Ca Larynx - Supraglottis	Malignant Neoplasm Of Extrinsic Larynx
Malignant Neoplasm Of Supraglottis	Malignant Supraglottic Tumor
Neoplasm Of Supraglottis

Microphthalmia, Isolated 4

Isolated Microphthalmia 4	MCOP4
Microphthalmia, Isolated, 4	Isolated Clinical Anophthalmia
Microphthalmia, Isolated, Type 4

Ulcerative Stomatitis

Stomatitis Ulcerative	Aphthous Stomatitis
Minor Oral Aphthous Ulceration

Leber Congenital Amaurosis 17

LCA17

Leber Congenital Amaurosis, Type 17

Noma

Cancrum Oris	Gangrenous Stomatitis
Oro-Facial Gangrene	Noma Neonatorum
Oral Gangrene	Oro-Facial Noma
Stomatitis Gangrenosa	Stomatonecrosis
Gangrene Stomatitis

Bladder Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Bladder	Epidermoid Carcinoma Of The Urinary Bladder
Carcinoma Squamous Cell Bladder

Afferent Loop Syndrome

Afferent Limb Syndrome

Multiple Synostoses Syndrome

Symphalangism-Brachydactyly Syndrome	Deafness-Hermann Type Symphalangism Syndrome
Facio-Audio-Symphalangism	Hearing Loss-Hermann Type Symphalangism Syndrome
Wl Syndrome	Multiple Synostosis Syndrome

Shipyard Eye

Epidemic Keratoconjunctivitis

Ekc

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09424	NOMO3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NOMO3	MGD	MGI:2385850

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