MAZ - MYC associated zinc finger protein Gene

Homo sapiens

Also known as PUR1; ZF87; Pur-1; SAF-1; SAF-2; SAF-3; Zif87; ZNF801

Gene ID: 4150 | Gene type: protein coding

About MAZ

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:29,806,124-29,811,164 (from NCBI)

This gene has 15 transcripts (splice variants), 248 orthologues and 36 paralogues. Ubiquitous expression in bone marrow (RPKM 38.3), colon (RPKM 34.1) and 25 other tissues.

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including regulation of gene expression; regulation of signal transduction; and transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

MAZ Products(4)

mRNA	Protein	Name
NM_001042539.3	NP_001036004.1	myc-associated zinc finger protein isoform 2
NM_001276275.2	NP_001263204.1	myc-associated zinc finger protein isoform 3
NM_001276276.2	NP_001263205.1	myc-associated zinc finger protein isoform 4
NM_002383.4	NP_002374.2	myc-associated zinc finger protein isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	25487955	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	1502157	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11527412	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of apoptotic signaling pathway	IDA IDA: Inferred from direct assay	25487955	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	26089202	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	25487955	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	25487955	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	25487955	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	25487955	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	25487955	GOA
involved in termination of RNA polymerase II transcription	IDA IDA: Inferred from direct assay	1502157	GOA
involved in transcription initiation at RNA polymerase II promoter	IDA IDA: Inferred from direct assay	1502157	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAZ Protein Structure

zf-C2H2_4

zf-H2C2_2

zf-C2H2

zf-C2H2_4

0
100
200
300
400
477 a.a.

Protein Preferred Names

Protein Names

myc-associated zinc finger protein

MAZI

MAZ Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MAZ	P56270	DCC	Homo sapiens	P43146	Y2H	11527412
Intra	MAZ	P56270	DCC	Homo sapiens	P43146	Pull Down	11527412
Cross	MAZ	P56270	Dcc	Mus musculus	P70211	Y2H	11527412
Intra	MAZ	P56270	APOD	Homo sapiens	P05090	Anti Tag CoIP	33961781
Intra	MAZ	P56270	APOD	Homo sapiens	P05090	Anti Tag CoIP	28514442
Cross	MAZ	P56270	dcc.L	Crosspus laevis	Q91562	Pull Down	11527412

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Amyloidosis

Amyloid Disease	Amyloid
Amyloid Degeneration	Amyloidosis Nos
Amyloid Deposition	Amyloid Infiltration
Idiopathic Amyloidosis	Hyaloid Degeneration
Lardaceous Degeneration

Von Hippel-Lindau Syndrome

Von Hippel-Lindau Disease	Vhl
Vhl Syndrome	VHLS
Von Hippel-Lindau Syndrome, Modifier Of	Hippel Lindau Syndrome
Angiomatosis Retinae	Cerebelloretinal Angiomatosis, Familial
Hippel-Lindau Disease	Familial Cerebelloretinal Angiomatosis
Lindau Disease	VHLD

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-116624	MAZ51		99.96%	Unkown
HY-RS08178	MAZ Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MAZ	VGNC	VGNC:54041
Rattus norvegicus	MAZ	RGD	RGD:1594632
Felis catus	MAZ	VGNC	VGNC:107761
Bos taurus	MAZ	VGNC	VGNC:106813
Mus musculus	MAZ	MGD	MGI:1338823

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