MCM3 - minichromosome maintenance complex component 3 Gene

Homo sapiens

Also known as HCC5; P1.h; RLFB; P1-MCM3

Gene ID: 4172 | Gene type: protein coding

About MCM3

Cytogenetic location: 6p12.2 Genomic coordinates (GRCh38): 6:52,264,015-52,284,742 (from NCBI)

This gene has 6 transcripts (splice variants), 208 orthologues and 8 paralogues. Ubiquitous expression in lymph node (RPKM 33.0), appendix (RPKM 23.5) and 24 other tissues.

Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2018]

MCM3 Products(9)

mRNA	Protein	Name
NM_001270472.3	NP_001257401.2	DNA replication licensing factor MCM3 isoform 2
NM_001366369.2	NP_001353298.1	DNA replication licensing factor MCM3 isoform 3
NM_001366370.2	NP_001353299.1	DNA replication licensing factor MCM3 isoform 4
NM_001366371.2	NP_001353300.1	DNA replication licensing factor MCM3 isoform 5
NM_001366372.2	NP_001353301.1	DNA replication licensing factor MCM3 isoform 6
NM_001366373.2	NP_001353302.1	DNA replication licensing factor MCM3 isoform 7
NM_001366374.2	NP_001353303.1	DNA replication licensing factor MCM3 isoform 8
NM_001366375.2	NP_001353304.1	DNA replication licensing factor MCM3 isoform 9
NM_002388.6	NP_002379.4	DNA replication licensing factor MCM3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12364596	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA unwinding involved in DNA replication	IDA IDA: Inferred from direct assay	22474384	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of CMG complex	IPI IPI: Inferred from physical interaction	22474384	GOA
part of MCM complex	IDA IDA: Inferred from direct assay	17296731	GOA
part of MCM complex	IPI IPI: Inferred from physical interaction	22540012	GOA
NOT located in nucleolus	IDA IDA: Inferred from direct assay	21383955	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20531406	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	20531406	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MCM3 Protein Structure

MCM_N

MCM

0
200
400
600
808 a.a.

Protein Preferred Names

Protein Names

DNA replication licensing factor MCM3

DNA polymerase alpha holoenzyme-associated protein P1

Related Diseases

Diseases

Alias

Anaplastic Astrocytoma

Grade Iii Astrocytoma	Astrocytoma, Anaplastic
Grade Iii Astrocytic Tumor

Cervical Cancer

Cervical Cancer, Somatic	Neoplasm Of Uterine Cervix
Cervix Cancer	Uterine Cervical Neoplasm
Cervical Neoplasm	Cervix Uteri Cancer
Tumor Of The Cervix Uteri	CERCA
Uterine Cervical Cancer	Neoplasms Cervical
Uterine Cervical Neoplasms	Cervical Cancers
Cancer, Cervical, Somatic	Malignant Tumor Of Cervix
Cervix Carcinoma

Meier-Gorlin Syndrome 5

MGORS5

Meier-Gorlin Syndrome, Type 5

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Meier-Gorlin Syndrome 1

Meier-Gorlin Syndrome	Ear, Patella, Short Stature Syndrome
Microtia, Absent Patellae, Micrognathia Syndrome	MGORS1
Eps	Ear-Patella-Short Stature Syndrome
Ear Patella Short Stature Syndrome	Microtia Absent Patellae Micrognathia Syndrome
Meier-Gorlin Syndrome, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08235	MCM3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08236	MCM3AP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MCM3	MGD	MGI:101845
Canis familiaris	MCM3	VGNC	VGNC:43082
Felis catus	MCM3	VGNC	VGNC:68213
Macaca mulatta	MCM3	VGNC	VGNC:74681
Rattus norvegicus	MCM3	RGD	RGD:1305168
Bos taurus	MCM3	VGNC	VGNC:31309

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