2. Gene
  3. MCMBP - minichromosome maintenance complex binding protein Gene

MCMBP - minichromosome maintenance complex binding protein Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MCM-BP; C10orf119

Gene ID: 79892 | Gene type: protein coding

About MCMBP

Cytogenetic location: 10q26.11 Genomic coordinates (GRCh38): 10:119,829,440-119,873,581 (from NCBI)

This gene has 5 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in placenta (RPKM 15.0), appendix (RPKM 14.1) and 25 other tissues.

Summary

This gene encodes a protein which is a component of the hexameric minichromosome maintenance (MCM) complex which regulates initiation and elongation of DNA. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

MCMBP Products(3)

mRNA Protein Name
NM_001256378.2 NP_001243307.1 mini-chromosome maintenance complex-binding protein isoform 2
NM_001256379.2 NP_001243308.1 mini-chromosome maintenance complex-binding protein isoform 3
NM_024834.4 NP_079110.1 mini-chromosome maintenance complex-binding protein isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables chromatin binding IDA
IDA: Inferred from direct assay
17296731 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17296731 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA-templated DNA replication IMP
IMP: Inferred from mutant phenotype
21196493 GOA
involved in sister chromatid cohesion IMP
IMP: Inferred from mutant phenotype
20090939 GOA
Cellular Component GO Annotation Evidence Reference Source
part of MCM complex IDA
IDA: Inferred from direct assay
17296731 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17296731 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MCMBP Protein Structure

MCM_bind

MCM_bind: Mini-chromosome maintenance replisome factor (37 - 166)

(353 - 451)

  • 0
  • 100
  • 200
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  • 400
  • 500
  • 600
  • 642 a.a.
Protein Preferred Names Protein Names

mini-chromosome maintenance complex-binding protein

MCM-binding protein

MCMBP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra MCMBP Q9BTE3 MCM3 Homo sapiens P25205
Pull Down
17296731
Intra MCMBP Q9BTE3 MCM3 Homo sapiens P25205
Anti Bait CoIP
22540012
Intra MCMBP Q9BTE3 MCM3 Homo sapiens P25205
Pull Down
22540012
Intra MCMBP Q9BTE3 MCM3 Homo sapiens P25205
Anti Tag CoIP
24299456
Intra MCMBP Q9BTE3 MCM3 Homo sapiens P25205
Anti Bait CoIP
24299456
Intra MCMBP Q9BTE3 MCM3 Homo sapiens P25205
Anti Bait CoIP
17296731
Intra MCMBP Q9BTE3 MCM3 Homo sapiens P25205
Anti Tag CoIP
25036637
Intra MCMBP Q9BTE3 MCM3 Homo sapiens P25205
TAP
17296731
Intra MCMBP Q9BTE3 MCM7 Homo sapiens P33993
Anti Bait CoIP
24299456
Intra MCMBP Q9BTE3 MCM7 Homo sapiens P33993
Anti Bait CoIP
17296731
Intra MCMBP Q9BTE3 MCM7 Homo sapiens P33993
Y2H Array
25416956
Intra MCMBP Q9BTE3 MCM7 Homo sapiens P33993
Anti Tag CoIP
25036637
Intra MCMBP Q9BTE3 MCM7 Homo sapiens P33993
TAP
17296731
Intra MCMBP Q9BTE3 MCM7 Homo sapiens P33993
Pull Down
22540012
Intra MCMBP Q9BTE3 MCM7 Homo sapiens P33993
Pull Down
17296731
Intra MCMBP Q9BTE3 MCM7 Homo sapiens P33993
Y2H Prey Pooling
25416956
Intra MCMBP Q9BTE3 MCM7 Homo sapiens P33993
Anti Bait CoIP
22540012
Intra MCMBP Q9BTE3 MCM7 Homo sapiens P33993
Anti Tag CoIP
24299456
Intra MCMBP Q9BTE3 MCM7 Homo sapiens P33993
Validated Y2H
25416956
Intra MCMBP Q9BTE3 MCM5 Homo sapiens P33992
Anti Bait CoIP
22540012
Intra MCMBP Q9BTE3 MCM5 Homo sapiens P33992
Pull Down
22540012
Intra MCMBP Q9BTE3 MCM5 Homo sapiens P33992
Pull Down
17296731
Intra MCMBP Q9BTE3 MCM5 Homo sapiens P33992
Anti Bait CoIP
24299456
Intra MCMBP Q9BTE3 MCM5 Homo sapiens P33992
Anti Bait CoIP
17296731
Intra MCMBP Q9BTE3 MCM5 Homo sapiens P33992
Anti Tag CoIP
25036637
Intra MCMBP Q9BTE3 MCM5 Homo sapiens P33992
Anti Tag CoIP
24299456
Intra MCMBP Q9BTE3 MCM5 Homo sapiens P33992
TAP
17296731
Intra MCMBP Q9BTE3 MCM2 Homo sapiens P49736
Anti Bait CoIP
22540012
Intra MCMBP Q9BTE3 MCM2 Homo sapiens P49736
Anti Bait CoIP
24299456
Intra MCMBP Q9BTE3 MCM2 Homo sapiens P49736
Anti Tag CoIP
25036637
Intra MCMBP Q9BTE3 MCM6 Homo sapiens Q14566
Anti Bait CoIP
22540012
Intra MCMBP Q9BTE3 MCM6 Homo sapiens Q14566
TAP
17296731
Intra MCMBP Q9BTE3 MCM6 Homo sapiens Q14566
Anti Bait CoIP
24299456
Intra MCMBP Q9BTE3 MCM6 Homo sapiens Q14566
Anti Tag CoIP
25036637
Intra MCMBP Q9BTE3 MCM6 Homo sapiens Q14566
Anti Bait CoIP
17296731
Intra MCMBP Q9BTE3 MCM6 Homo sapiens Q14566
Anti Tag CoIP
24299456
Intra MCMBP Q9BTE3 MCM6 Homo sapiens Q14566
Pull Down
22540012
Intra MCMBP Q9BTE3 MCM6 Homo sapiens Q14566
Pull Down
17296731
Intra MCMBP Q9BTE3 MCM4 Homo sapiens P33991
Anti Bait CoIP
22540012
Intra MCMBP Q9BTE3 MCM4 Homo sapiens P33991
Pull Down
17296731
Intra MCMBP Q9BTE3 MCM4 Homo sapiens P33991
Anti Bait CoIP
24299456
Intra MCMBP Q9BTE3 MCM4 Homo sapiens P33991
Anti Bait CoIP
17296731
Intra MCMBP Q9BTE3 MCM4 Homo sapiens P33991
Anti Tag CoIP
24299456
Intra MCMBP Q9BTE3 MCM4 Homo sapiens P33991
Pull Down
22540012
Intra MCMBP Q9BTE3 MCM4 Homo sapiens P33991
Anti Tag CoIP
25036637
Intra MCMBP Q9BTE3 MCM4 Homo sapiens P33991
TAP
17296731
Intra MCMBP Q9BTE3 CDC7 Homo sapiens O00311
Anti Bait CoIP
22540012
Intra MCMBP Q9BTE3 CDC7 Homo sapiens O00311
Anti Bait CoIP
24299456
Intra MCMBP Q9BTE3 GINS2 Homo sapiens Q9Y248
Anti Bait CoIP
22540012
Intra MCMBP Q9BTE3 GINS2 Homo sapiens Q9Y248
Anti Bait CoIP
24299456
Intra MCMBP Q9BTE3 GINS4 Homo sapiens Q9BRT9
Anti Bait CoIP
24299456
Intra MCMBP Q9BTE3 SMC3 Homo sapiens Q9UQE7
Anti Bait CoIP
22540012
Intra MCMBP Q9BTE3 SMC3 Homo sapiens Q9UQE7
Anti Bait CoIP
24299456
Intra MCMBP Q9BTE3 MCM8 Homo sapiens Q9UJA3
Anti Tag CoIP
25036637
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Humeroradial Synostosis

Humero-Radial Fusion

Humero-Radial Synostosis

Ramer Ladda Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08243 MCMBP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MCMBP MGD MGI:1920977
Bos taurus MCMBP VGNC VGNC:31316
Felis catus MCMBP VGNC VGNC:63416
Rattus norvegicus MCMBP RGD RGD:1306730
Macaca mulatta MCMBP VGNC VGNC:74583