2. Gene
  3. ME2 - malic enzyme 2 Gene

ME2 - malic enzyme 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ODS1

Gene ID: 4200 | Gene type: protein coding

About ME2

Cytogenetic location: 18q21.2 Genomic coordinates (GRCh38): 18:50,879,118-50,954,257 (from NCBI)

This gene has 19 transcripts (splice variants), 212 orthologues and 2 paralogues. Ubiquitous expression in duodenum (RPKM 15.0), colon (RPKM 14.1) and 25 other tissues.

Summary

This gene encodes a mitochondrial NAD-dependent malic Enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene. [provided by RefSeq, Dec 2009]

ME2 Products(2)

mRNA Protein Name
NM_001168335.2 NP_001161807.1 NAD-dependent malic enzyme, mitochondrial isoform 2 precursor
NM_002396.5 NP_002387.1 NAD-dependent malic enzyme, mitochondrial isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables malic enzyme activity IMP
IMP: Inferred from mutant phenotype
23334421 GOA
Biological Process GO Annotation Evidence Reference Source
involved in regulation of NADP metabolic process IMP
IMP: Inferred from mutant phenotype
23334421 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ME2 Protein Structure

malic

malic: Malic enzyme, N-terminal domain (89 - 270)

Malic_M

Malic_M: Malic enzyme, NAD binding domain (280 - 533)

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  • 500
  • 584 a.a.
Protein Preferred Names Protein Names

NAD-dependent malic enzyme, mitochondrial

NAD-ME

Recombinant ME2 Proteins

Cat. No. Product Name Accession Purity
HY-P71918A NAD-ME Protein, Human (N-His) P23368-1 (L19-E584) ≥95%

Related Diseases

Diseases Alias
Epilepsy, Idiopathic Generalized

Idiopathic Generalized Epilepsy

Generalised Epilepsy

Epilepsy, Generalized

EIG

Ige

Epilepsy, Idiopathic Generalized, Susceptibility To, 1

Epilepsy, Idiopathic Generalized 1

Epilepsy, Idiopathic Generalized, Susceptibility To

Epilepsy, Idiopathic, Generalized

Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 1
Epilepsy

Epilepsy Syndrome

Epileptic Syndrome

Epilepsies

Symptomatic Epilepsies

Post Traumatic Epilepsy

Traumatic Epilepsy

Traumatic Epileptic

Epilepsy Due To Hippocampal Sclerosis

Epilepsy With Ammon'S Horn Sclerosis

Epilepsy Due To Cortical Dysplasia

Epilepsy Due To Neuronal Migration Disorders
Epilepsy, Myoclonic Juvenile

Juvenile Myoclonic Epilepsy

Janz Syndrome

Jme

Myoclonic Epilepsy, Juvenile, Susceptibility To, 1

EJM

Myoclonic Epilepsy, Juvenile

Petit Mal, Impulsive

Myoclonic Epilepsy, Juvenile 1

Myoclonic Epilepsy, Juvenile, 1

Adolescent Myoclonic Epilepsy

Juvenile Myoclonus Epilepsy

Juvenile Myoclonic Epilepsy 1

EJM1

Petit Mal Impulsive

Susceptibility To Juvenile Myoclonic Epilepsy 1

Myoclonic Epilepsy Juvenile

Epilepsy, Myoclonic, Juvenile

Myoclonic Epilepsy Of Janz

Jme - [Juvenile Myoclonic Epilepsy]
Generalized Epilepsy With Febrile Seizures Plus

Gefs+

Genetic Epilepsy With Febrile Seizures Plus

Generalized Epilepsy With Febrile Seizures-Plus

Genetic Epilepsy With Febrile Seizures-Plus

Epilepsy, Generalized, With Febrile Seizures Plus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-12033 2-Methoxyestradiol 99.82% Phase 2
Pre-clinical Phase
Bioactive Molecules (48)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15648B GSK-J4 99.64% Unkown
HY-D0858 MES 99.93% Unkown
HY-15648 GSK-J1 Inhibitor 99.94% Unkown
HY-15648F GSK-J4 hydrochloride Inhibitor 98.83% Unkown
HY-13808 UNC 0631 Inhibitor 98.35% Unkown
HY-13807 UNC0646 Inhibitor 99.38% Unkown
HY-157251 UNC8153 TFA Inhibitor 99.91% Unkown
HY-136964 Sulfo-NHS-Biotin sodium ≥95.0% Unkown
HY-D0858A MES monohydrate 99.87% Unkown
HY-100360 MS049 Inhibitor ≥98.0% Unkown
HY-152775 RK-701 Inhibitor 98.04% Unkown
HY-15648A GSK-J2 99.76% Unkown
HY-D0858B MES sodium salt ≥98.0% Unkown
HY-66025 Fmoc-Lys(Me)2-OH hydrochloride 97.52% Unkown
HY-150510 MS8511 Inhibitor / Unkown
HY-D0858C MES hydrate 99.90% Unkown
HY-128579 DW14800 Inhibitor 99.63% Unkown
HY-D0858S MES-d13 98.78% Unkown
HY-156285 ZZM-1220 98.74% Unkown
HY-W127629 MOBS ≥98.0% Unkown
HY-12033S2 2-Methoxyestradiol-d5 97.90% Unkown
HY-100360A MS049 dihydrochloride Inhibitor / Unkown
HY-116971 DCG066 / Unkown
HY-12033S 2-Methoxyestradiol-13C,d3 / Unkown
HY-12033S1 2-Methoxyestradiol-13C6 / Unkown
HY-122595 EZH2-IN-1 Inhibitor / Unkown
HY-128931 NH2-Ph-C4-acid-NH2-Me / Unkown
HY-138604 5'-O-DMT-N6-Me-2'-dA Activator 98.00% Unkown
HY-154224 2’-O-Me-2-thio-U-3’-phos phoramidite / Unkown
HY-155817 UNC7096 Chemical / Unkown
HY-15648G GSK-J1 sodium Inhibitor / Unkown
HY-15648I GSK-J2 sodium / Unkown
HY-161313 DYB-03 Inhibitor 99.49% Unkown
HY-161787 G9a-IN-2 Inhibitor / Unkown
HY-163545 Tc-Me2P / Unkown
HY-164456 AMI-408 Inhibitor / Unkown
HY-44062 G9a-IN-1 Inhibitor 98.12% Unkown
HY-D0858E MES potassium / Unkown
HY-P1162 (d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin Antagonist / Unkown
HY-P2014 (d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin Antagonist / Unkown
HY-P4397 (d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin / Unkown
HY-P4895 (d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin Antagonist / Unkown
HY-P5006 (d(CH2)51,Tyr(Me)2,Dab5,Arg8)-Vasopressin Antagonist / Unkown
HY-RS08271 ME2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-15648D GSK-J1 lithium salt Inhibitor 98.26% Unkown
HY-157251A UNC8153 Inhibitor / Unkown
HY-169217 CYP3A4-IN-4 Inhibitor / Unkown
HY-D0858D MES hemisodium Chemical ≥98.0% Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ME2 VGNC VGNC:97791
Felis catus ME2 VGNC VGNC:68226
Canis familiaris ME2 VGNC VGNC:43110
Rattus norvegicus ME2 RGD RGD:1310321
Mus musculus ME2 MGD MGI:2147351
Bos taurus ME2 VGNC VGNC:31340
Others ME2 NCBI