MEP1B - meprin A subunit beta Gene

Homo sapiens

Gene ID: 4225 | Gene type: protein coding

About MEP1B

Cytogenetic location: 18q12.1 Genomic coordinates (GRCh38): 18:32,190,039-32,220,404 (from NCBI)

This gene has 4 transcripts (splice variants), 280 orthologues and 35 paralogues. Biased expression in small intestine (RPKM 150.9) and duodenum (RPKM 98.0).

Summary

Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain Cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in Cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine. [provided by RefSeq, Oct 2011]

MEP1B Products(2)

mRNA	Protein	Name
NM_001308171.2	NP_001295100.1	meprin A subunit beta isoform 2 precursor
NM_005925.3	NP_005916.2	meprin A subunit beta isoform 1 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	22988105	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9288916	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of meprin A complex	IDA IDA: Inferred from direct assay	9288916	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	9288916	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MEP1B Protein Structure

Astacin

MAM

MATH

0
200
400
600
701 a.a.

Protein Preferred Names

Protein Names

meprin A subunit beta

N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta

MEP1B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MEP1B	Q16820	MMP9	Homo sapiens	P14780	Enzymatic Study	23123160
Intra	MEP1B	Q16820	TSPAN8	Homo sapiens	P19075	Ub Reconstruction	27180358
Intra	MEP1B	Q16820	TSPAN8	Homo sapiens	P19075	Complementation	27180358
Intra	MEP1B	Q16820	TSPAN8	Homo sapiens	P19075	SLC	27180358
Intra	MEP1B	Q16820	C11orf24	Homo sapiens	Q96F05	Ub Reconstruction	27180358
Intra	MEP1B	Q16820	ATP5MC3	Homo sapiens	P48201	Ub Reconstruction	27180358
Intra	MEP1B	Q16820	HLA-A	Homo sapiens	P10316	Ub Reconstruction	27180358
Intra	MEP1B	Q16820	CCDC167	Homo sapiens	Q9P0B6	Ub Reconstruction	27180358
Intra	MEP1B	Q16820	CYSTM1	Homo sapiens	Q9H1C7	Ub Reconstruction	27180358
Intra	MEP1B	Q16820	C8orf44	Homo sapiens	Q96CB5	Ub Reconstruction	27180358
Intra	MEP1B	Q16820	AQP7	Homo sapiens	O14520	Ub Reconstruction	27180358
Intra	MEP1B	Q16820	ARL14	Homo sapiens	Q8N4G2	Ub Reconstruction	27180358
Intra	MEP1B	Q16820	CPNE3	Homo sapiens	O75131	Ub Reconstruction	27180358
Intra	MEP1B	Q16820	MEP1B	Homo sapiens	Q16820	SLC	27180358
Intra	MEP1B	Q16820	APOC3	Homo sapiens	P02656	Ub Reconstruction	27180358
Intra	MEP1B	Q16820	HLA-DMA	Homo sapiens	P28067	Ub Reconstruction	27180358
Intra	MEP1B	Q16820	CHPT1	Homo sapiens	Q8WUD6	Ub Reconstruction	27180358
Intra	MEP1B	Q16820	MEP1B	Homo sapiens	Q16820	X-Ray Diffraction	22988105
Intra	MEP1B	Q16820	AIG1	Homo sapiens	Q9NVV5	Ub Reconstruction	27180358

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Colorado Tick Fever

Mountain Tick Fever	Tick Fever, American Mountain
American Mountain Fever	Colorado Tick Encephalitis
Colorado Tick-Borne Disease	Mountain Fever
American Mountain Tick Fever	Colorado Tick-Borne Fever
Colorado Tick Fever Virus	Non-Exanthematous Tick Fever

Powassan Encephalitis

Powassan Encephalitis Virus Infection

Anisakiasis

Infection By Anisakis Larva	Anisakis Infection
Pseudoterranova Infection	Anisakiasis Due To Anisakis Simplex
Anisakiasis Due To Pseudoterranova Decipiens	Anisakis Infestation
Infection Due To Anisakis Larvae

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08337	MEP1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MEP1B	RGD	RGD:3081
Bos taurus	MEP1B	VGNC	VGNC:31389
Mus musculus	MEP1B	MGD	MGI:96964
Macaca mulatta	MEP1B	VGNC	VGNC:74705
Felis catus	MEP1B	VGNC	VGNC:68236
Canis familiaris	MEP1B	VGNC	VGNC:43160

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