2. Gene
  3. MAP3K9 - mitogen-activated protein kinase kinase kinase 9 Gene

MAP3K9 - mitogen-activated protein kinase kinase kinase 9 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MLK1; MEKK9; PRKE1

Gene ID: 4293 | Gene type: protein coding

About MAP3K9

Cytogenetic location: 14q24.2 Genomic coordinates (GRCh38): 14:70,722,526-70,809,513 (from NCBI)

This gene has 6 transcripts (splice variants), 194 orthologues and 23 paralogues. Broad expression in brain (RPKM 3.6), testis (RPKM 3.0) and 22 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in protein autophosphorylation. [provided by Alliance of Genome Resources, Apr 2022]

MAP3K9 Products(4)

mRNA Protein Name
NM_001284230.2 NP_001271159.1 mitogen-activated protein kinase kinase kinase 9 isoform 2
NM_001284231.1 NP_001271160.1 mitogen-activated protein kinase kinase kinase 9 isoform 3
NM_001284232.1 NP_001271161.1 mitogen-activated protein kinase kinase kinase 9 isoform 4
NM_033141.4 NP_149132.2 mitogen-activated protein kinase kinase kinase 9 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables molecular function activator activity EXP
EXP: Inferred from Experiment
18714982 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22939624 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
15610029 GOA
Biological Process GO Annotation Evidence Reference Source
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
15610029 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
15610029 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP3K9 Protein Structure

SH3_9

SH3_9: Variant SH3 domain (59 - 112)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (144 - 403)

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  • 1104 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase 9

mixed lineage kinase 1 (tyr and ser/thr specificity)

MAP3K9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra MAP3K9 P80192 YWHAG Homo sapiens P61981
Validated Y2H
32814053
Intra MAP3K9 P80192 YWHAG Homo sapiens P61981
Y2H Pooling
32814053
Intra MAP3K9 P80192 YWHAG Homo sapiens P61981
Y2H Array
32814053
Intra MAP3K9 P80192 SETDB1 Homo sapiens Q15047-2
Validated Y2H
32814053
Intra MAP3K9 P80192 SETDB1 Homo sapiens Q15047-2
Y2H Array
32814053
Intra MAP3K9 P80192 SETDB1 Homo sapiens Q15047-2
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Retroperitoneal Neuroblastoma
Retroperitoneum Carcinoma

Retroperitoneal Cancer

Malignant Neoplasm Of Retroperitoneum And Peritoneum

Retroperitoneal Neoplasms

Carcinoma Of Retroperitoneum

Carcinoma Of The Retroperitoneum

Malignant Neoplasm Of Retroperitoneum

Malignant Retroperitoneal Cancer

Malignant Tumor Of Peritoneum And Retroperitoneum

Neoplasm Of Retroperitoneum

Neoplasm Of The Retroperitoneum

Retroperitoneal Neoplasm

Tumor Of Retroperitoneum

Malignant Retroperitoneal Tumour

Primary Malignant Neoplasm Of Retroperitoneum

Retroperitoneum Cancer
Immunodeficiency 71 With Inflammatory Disease And Congenital Thrombocytopenia

Platelet Abnormalities With Eosinophilia And Immune-Mediated Inflammatory Disease

IMD71

Plteid

Immunodeficiency 71
Esophageal Cancer

Esophageal Carcinoma

Carcinoma Of Esophagus

Esophageal Squamous Cell Carcinoma, Somatic

Esophageal Carcinoma, Somatic

Esophagus Cancer

Gastric Cardia Adenocarcinoma

Esophageal Neoplasms

Esophageal Cancer, Somatic

Cancer Of Esophagus

Cancer Of Oesophagus

Carcinoma Of Oesophagus

Ca Lower Third Oesophagus

Ca Middle Third Oesophagus

Malignant Neoplasm Of Distal Third Of Esophagus

Malignant Neoplasm Of Lower Third Of Oesophagus

Malignant Neoplasm Of Middle Third Of Oesophagus

Malignant Neoplasm Of Proximal Third Of Esophagus

Malignant Neoplasm Of Upper Third Esophagus

Malignant Tumor Of Abdominal Esophagus

Malignant Tumor Of Distal Third Of Esophagus

Malignant Tumor Of Proximal Third Of Esophagus

Malignant Tumor Of The Middle Third Of The Esophagus

ESCR

Aerodigestive Tract Cancer

Escc

Esophageal Squamous Cell Carcinoma

Cancer, Esophageal

Malignant Neoplasm Of Esophagus

Squamous Cell Carcinoma Of Esophagus

Malignant Neoplasm Of Middle Third Of Esophagus
Ecthyma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08069 MAP3K9 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MAP3K9 MGD MGI:2449952
Rattus norvegicus MAP3K9 RGD RGD:1562149
Canis familiaris MAP3K9 VGNC VGNC:42980
Bos taurus MAP3K9 VGNC VGNC:31203
Macaca mulatta MAP3K9 VGNC VGNC:74498