MT2A - metallothionein 2A Gene

Homo sapiens

Also known as MT2; MT-2; MT-II

Gene ID: 4502 | Gene type: protein coding

About MT2A

Cytogenetic location: 16q13 Genomic coordinates (GRCh38): 16:56,608,584-56,609,497 (from NCBI)

This gene has 5 transcripts (splice variants), 156 orthologues and 11 paralogues. Broad expression in adrenal (RPKM 718.8), liver (RPKM 608.8) and 20 other tissues.

Summary

This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions, altering the intracellular concentration of heavy metals in the cell. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. The encoded protein interacts with the protein encoded by the homeobox containing 1 gene in some cell types, controlling intracellular zinc levels, affecting apoptotic and Autophagy pathways. Some polymorphisms in this gene are associated with an increased risk of Cancer. [provided by RefSeq, Sep 2017]

MT2A Products(1)

mRNA	Protein	Name
NM_005953.5	NP_005944.1	metallothionein-2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12646258	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to erythropoietin	IEP IEP: Inferred from expression pattern	11168427	GOA
involved in cellular response to interleukin-3	IEP IEP: Inferred from expression pattern	11168427	GOA
involved in cellular response to zinc ion	IEP IEP: Inferred from expression pattern	11168427	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MT2A Protein Structure

Metallothio

0
61 a.a.

Protein Preferred Names

Protein Names

metallothionein-2

metallothionein-II

Related Diseases

Diseases

Alias

Scrapie

Osteogenesis Imperfecta, Type X

Osteogenesis Imperfecta Type 10	OI10
Osteogenesis Imperfecta Type X	Oi, Type X
Osteogenesis Imperfecta 10	Oi Type X
Oi-X

Esophageal Cancer

Esophageal Carcinoma	Carcinoma Of Esophagus
Esophageal Squamous Cell Carcinoma, Somatic	Esophageal Carcinoma, Somatic
Esophagus Cancer	Gastric Cardia Adenocarcinoma
Esophageal Neoplasms	Esophageal Cancer, Somatic
Cancer Of Esophagus	Cancer Of Oesophagus
Carcinoma Of Oesophagus	Ca Lower Third Oesophagus
Ca Middle Third Oesophagus	Malignant Neoplasm Of Distal Third Of Esophagus
Malignant Neoplasm Of Lower Third Of Oesophagus	Malignant Neoplasm Of Middle Third Of Oesophagus
Malignant Neoplasm Of Proximal Third Of Esophagus	Malignant Neoplasm Of Upper Third Esophagus
Malignant Tumor Of Abdominal Esophagus	Malignant Tumor Of Distal Third Of Esophagus
Malignant Tumor Of Proximal Third Of Esophagus	Malignant Tumor Of The Middle Third Of The Esophagus
ESCR	Aerodigestive Tract Cancer
Escc	Esophageal Squamous Cell Carcinoma
Cancer, Esophageal	Malignant Neoplasm Of Esophagus
Squamous Cell Carcinoma Of Esophagus	Malignant Neoplasm Of Middle Third Of Esophagus

Menkes Disease

Copper Transport Disease	Menkes Syndrome
MNK	Kinky Hair Disease
Steely Hair Disease	Menkes Kinky-Hair Syndrome
Mk	Steely Hair Syndrome
Menkea Syndrome	Md
Menkes Kinky Hair Syndrome	Hypocupremia, Congenital
Kinky Hair Syndrome	X-Linked Copper Deficiency
Menkes Kinky Hair Disease

Deficiency Anemia

Anemia	Deficiency Anemias
Anaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08743	MT2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MT2A	MGD	MGI:97172
Rattus norvegicus	MT2A	RGD	RGD:1592345

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