MTF1 - metal regulatory transcription factor 1 Gene

Homo sapiens

Also known as ZRF; MTF-1

Gene ID: 4520 | Gene type: protein coding

About MTF1

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:37,809,574-37,859,592 (from NCBI)

This gene has 2 transcripts (splice variants), 209 orthologues, 36 paralogues and is associated with 1 phenotype. Ubiquitous expression in bone marrow (RPKM 7.9), testis (RPKM 4.9) and 25 other tissues.

Summary

This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE). [provided by RefSeq, Jul 2008]

MTF1 Products(1)

mRNA	Protein	Name
NM_005955.3	NP_005946.2	metal regulatory transcription factor 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	9582278	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9582278	GOA
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15735762	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9582278	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MTF1 Protein Structure

zf-C2H2

zf-H2C2_2

0
200
400
600
753 a.a.

Protein Preferred Names

Protein Names

metal regulatory transcription factor 1

MRE-binding transcription factor

Related Diseases

Diseases

Alias

Dentine Erosion

Enamel Erosion

Tooth Erosion

Generalized Erosion	Localized Erosion
Generalized Erosions	Erosion, Localized

Atrial Septal Defect 2

ASD2	Atrial Heart Septal Defect 2
Atrial Septal Defect-2	Asd Ii
Septal Defect, Atrial, Type 2

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08765	MTF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MTF1	VGNC	VGNC:43466
Mus musculus	MTF1	MGD	MGI:101786
Bos taurus	MTF1	VGNC	VGNC:31722
Rattus norvegicus	MTF1	RGD	RGD:1308956
Macaca mulatta	MTF1	VGNC	VGNC:74946
Felis catus	MTF1	VGNC	VGNC:68338

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