NAP1L4 - nucleosome assembly protein 1 like 4 Gene

Homo sapiens

Also known as NAP2; NAP2L; hNAP2; NAP1L4b

Gene ID: 4676 | Gene type: protein coding

About NAP1L4

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:2,944,437-2,992,329 (from NCBI)

This gene has 23 transcripts (splice variants), 1 gene allele, 159 orthologues and 18 paralogues. Ubiquitous expression in testis (RPKM 52.4), heart (RPKM 37.7) and 25 other tissues.

Summary

This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast Cancer. [provided by RefSeq, Jul 2008]

NAP1L4 Products(14)

mRNA	Protein	Name
NM_001369375.1	NP_001356304.1	nucleosome assembly protein 1-like 4 isoform 1
NM_001369376.1	NP_001356305.1	nucleosome assembly protein 1-like 4 isoform 1
NM_001369377.1	NP_001356306.1	nucleosome assembly protein 1-like 4 isoform 1
NM_001369378.1	NP_001356307.1	nucleosome assembly protein 1-like 4 isoform 1
NM_001369379.1	NP_001356308.1	nucleosome assembly protein 1-like 4 isoform 1
NM_001369380.1	NP_001356309.1	nucleosome assembly protein 1-like 4 isoform 2
NM_001369381.1	NP_001356310.1	nucleosome assembly protein 1-like 4 isoform 2
NM_001369382.1	NP_001356311.1	nucleosome assembly protein 1-like 4 isoform 2
NM_001369383.1	NP_001356312.1	nucleosome assembly protein 1-like 4 isoform 2
NM_001369384.1	NP_001356313.1	nucleosome assembly protein 1-like 4 isoform 2
NM_001369385.1	NP_001356314.1	nucleosome assembly protein 1-like 4 isoform 2
NM_001369386.1	NP_001356315.1	nucleosome assembly protein 1-like 4 isoform 2
NM_001369388.1	NP_001356317.1	nucleosome assembly protein 1-like 4 isoform 2
NM_005969.4	NP_005960.1	nucleosome assembly protein 1-like 4 isoform 1

NAP1L4 Protein Structure

NAP

0
100
200
300
375 a.a.

Protein Preferred Names

Protein Names

nucleosome assembly protein 1-like 4

NAP-2

Related Diseases

Diseases

Alias

Beckwith-Wiedemann Syndrome

Wiedemann-Beckwith Syndrome	BWS
Exomphalos-Macroglossia-Gigantism Syndrome	Emg Syndrome
Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation	Emg Abnormality
Wbs	Exomphalos Macroglossia Gigantism Syndrome
Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation	Macroglossia Exomphalos Gigantism

Chikungunya

Chikungunya Fever	Arbovirus A Chikungunya Type
Chik	Chikv Infection
Ck	Chikungunya Virus Infection
Chikungunya Haemorrhagic Fever	Chikungunya Viral Disease
Chikungunya Mosquito-Borne Viral Fever

Wilms Tumor 5

Wilms Tumor	WT5
Wilms Tumor Susceptibility-5	Wilms Tumor And Radial Bilateral Aplasia
Nephroblastoma	Wilms' Tumor
Wilms Tumor, Susceptibility To	Wtsl
Bilateral Radial Aplasia With Wilms Tumor	Embryonal Adenosarcoma
Embryonal Nephroma	Kidney Wilms Tumor
Kidney, Adenomyosarcoma, Embryonal	Kidney, Carcinosarcoma, Embryonal
Kidney, Embryoma	Kidney, Embryonal Mixed Tumor
Nephroma	Renal Adenosarcoma
Renal Cancer, Wilms	Renal Wilms Tumor
Tumor, Wilms	Hereditary Susceptibility To Wilms Tumor 5

Familial Apolipoprotein C-Ii Deficiency

Familial Apoc-Ii Deficiency	Familial Apoc2 Deficiency
C-Ii Anapolipoproteinemia	Hyperlipoproteinemia, Type 1b
Hyperlipoproteinemia, Type Ib	Hyperlipoproteinemia Type I

Polyhydramnios

Cockayne Syndrome A

Cockayne Syndrome Type 1	Cockayne Syndrome, Type A
Cockayne Syndrome Type I	CSA
Cockayne Syndrome Classic Form	Cockayne Syndrome Classical
Cockayne Syndrome Type A	Ckn1

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09028	NAP1L4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NAP1L4	VGNC	VGNC:101365
Rattus norvegicus	NAP1L4	RGD	RGD:1305391
Felis catus	NAP1L4	VGNC	VGNC:68413
Bos taurus	NAP1L4	VGNC	VGNC:31879
Mus musculus	NAP1L4	MGD	MGI:1316687
Canis familiaris	NAP1L4	VGNC	VGNC:43617

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