NAP1L1 - nucleosome assembly protein 1 like 1 Gene

Homo sapiens

Also known as NRP; NAP1; NAP1L

Gene ID: 4673 | Gene type: protein coding

About NAP1L1

Cytogenetic location: 12q21.2 Genomic coordinates (GRCh38): 12:76,036,585-76,084,685 (from NCBI)

This gene has 26 transcripts (splice variants), 239 orthologues and 18 paralogues. Ubiquitous expression in ovary (RPKM 100.8), lymph node (RPKM 74.3) and 25 other tissues.

Summary

This gene encodes a member of the nucleosome assembly protein (NAP) family. This protein participates in DNA replication and may play a role in modulating chromatin formation and contribute to the regulation of cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms; however, not all have been fully described. [provided by RefSeq, Apr 2015]

NAP1L1 Products(5)

mRNA	Protein	Name
NM_001307924.3	NP_001294853.1	nucleosome assembly protein 1-like 1 isoform 2
NM_001330231.2	NP_001317160.1	nucleosome assembly protein 1-like 1 isoform 1
NM_001330232.2	NP_001317161.1	nucleosome assembly protein 1-like 1 isoform 3
NM_004537.7	NP_004528.1	nucleosome assembly protein 1-like 1 isoform 1
NM_139207.5	NP_631946.1	nucleosome assembly protein 1-like 1 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables histone chaperone activity	IDA IDA: Inferred from direct assay	21211722	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11940655	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAP1L1 Protein Structure

NAP

0
100
200
300
391 a.a.

Protein Preferred Names

Protein Names

nucleosome assembly protein 1-like 1

HSP22-like protein interacting protein

NAP1L1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NAP1L1	P55209	NAP1L4	Homo sapiens	Q99733	Anti Tag CoIP	33961781
Intra	NAP1L1	P55209	NAP1L4	Homo sapiens	Q99733	Anti Tag CoIP	28514442
Intra	NAP1L1	P55209	NR2F6	Homo sapiens	P10588	TAP	20195357
Intra	NAP1L1	P55209	DLST	Homo sapiens	P36957	Y2H Pooling	16169070
Intra	NAP1L1	P55209	RPL23A	Homo sapiens	P62750	Anti Tag CoIP	33961781
Intra	NAP1L1	P55209	NAP1L2	Homo sapiens	Q9ULW6	Y2H Prey Pooling	32296183
Intra	NAP1L1	P55209	NAP1L2	Homo sapiens	Q9ULW6	Y2H Array	32296183
Intra	NAP1L1	P55209	NAP1L2	Homo sapiens	Q9ULW6	Validated Y2H	32296183
Intra	NAP1L1	P55209	EP300	Homo sapiens	Q09472	Pull Down	11940655
Intra	NAP1L1	P55209	EP300	Homo sapiens	Q09472	Anti Bait CoIP	11940655
Intra	NAP1L1	P55209	TERF1	Homo sapiens	P54274	Pull Down	21044950
Intra	NAP1L1	P55209	TTLL10	Homo sapiens	Q6ZVT0	Anti Bait CoIP	18331838
Intra	NAP1L1	P55209	TTLL10	Homo sapiens	Q6ZVT0	Enzymatic Study	18331838
Intra	NAP1L1	P55209	GAS2L2	Homo sapiens	Q8NHY3	Validated Y2H	32296183
Intra	NAP1L1	P55209	CREBBP	Homo sapiens	Q92793	Pull Down	11940655
Cross	NAP1L1	P55209	tat	Human immunodeficiency virus	P04608	Pull Down	18226242

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Human Herpesvirus 8

HHV8S	Human Herpesvirus 8, Susceptibility To
Hhv-8	Hhv-8, Susceptibility To
HHV8	Kaposi Sarcoma

Chikungunya

Chikungunya Fever	Arbovirus A Chikungunya Type
Chik	Chikv Infection
Ck	Chikungunya Virus Infection
Chikungunya Haemorrhagic Fever	Chikungunya Viral Disease
Chikungunya Mosquito-Borne Viral Fever

Polyhydramnios

Cockayne Syndrome A

Cockayne Syndrome Type 1	Cockayne Syndrome, Type A
Cockayne Syndrome Type I	CSA
Cockayne Syndrome Classic Form	Cockayne Syndrome Classical
Cockayne Syndrome Type A	Ckn1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125876	PROTAC Bcl2 degrader-1	Inhibitor	99.80%	Unkown
HY-RS09026	NAP1L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NAP1L1	VGNC	VGNC:57999
Felis catus	NAP1L1	VGNC	VGNC:97521
Mus musculus	NAP1L1	MGD	MGI:1855693
Macaca mulatta	NAP1L1	VGNC	VGNC:100082
Rattus norvegicus	NAP1L1	RGD	RGD:71094

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