NASP - nuclear autoantigenic sperm protein Gene

Homo sapiens

Also known as HMDRA1; FLB7527; PRO1999

Gene ID: 4678 | Gene type: protein coding

About NASP

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:45,584,041-45,618,893 (from NCBI)

This gene has 25 transcripts (splice variants) and 273 orthologues. Ubiquitous expression in testis (RPKM 44.0), bone marrow (RPKM 30.2) and 24 other tissues.

Summary

This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa. [provided by RefSeq, Jul 2008]

NASP Products(3)

mRNA	Protein	Name
NM_001195193.2	NP_001182122.1	nuclear autoantigenic sperm protein isoform 4
NM_002482.4	NP_002473.2	nuclear autoantigenic sperm protein isoform 2
NM_152298.4	NP_689511.2	nuclear autoantigenic sperm protein isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables histone binding	IDA IDA: Inferred from direct assay	27618665	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	25615412	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in nucleosome assembly	IDA IDA: Inferred from direct assay	14718166	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	14718166	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	14718166	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NASP Protein Structure

SHNi-TPR

TPR_1

0
200
400
600
788 a.a.

Protein Preferred Names

Protein Names

nuclear autoantigenic sperm protein

NASP histone chaperone

NASP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NASP	P49321	TERF2IP	Homo sapiens	Q9NYB0	Pull Down	21044950
Intra	NASP	P49321	H3C1	Homo sapiens	P68431	Anti Tag CoIP	33961781
Intra	NASP	P49321	H3C1	Homo sapiens	P68431	TAP	24981860
Intra	NASP	P49321	H3C1	Homo sapiens	P68431	Y2H Pooling	16189514
Intra	NASP	P49321	H3C1	Homo sapiens	P68431	Y2H Array	31515488

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Factitious Disorder

Munchausen Syndrome	Factitious Disorders
Münchausen Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09038	NASP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NASP	VGNC	VGNC:43626
Rattus norvegicus	NASP	RGD	RGD:1359609
Felis catus	NASP	VGNC	VGNC:68417
Mus musculus	NASP	MGD	MGI:1355328
Bos taurus	NASP	VGNC	VGNC:31887
Macaca mulatta	NASP	VGNC	VGNC:82193
Others	NASP	NCBI

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