NCAM2 - neural cell adhesion molecule 2 Gene

Homo sapiens

Also known as NCAM21

Gene ID: 4685 | Gene type: protein coding

About NCAM2

Cytogenetic location: 21q21.1 Genomic coordinates (GRCh38): 21:20,998,409-21,543,329 (from NCBI)

This gene has 5 transcripts (splice variants), 217 orthologues and 36 paralogues. Biased expression in brain (RPKM 13.1), adrenal (RPKM 3.2) and 3 other tissues.

Summary

The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein and may function in selective fasciculation and zone-to-zone projection of the primary olfactory axons. [provided by RefSeq, Jul 2008]

NCAM2 Products(8)

mRNA	Protein	Name
NM_001352591.2	NP_001339520.1	neural cell adhesion molecule 2 isoform 1 precursor
NM_001352592.2	NP_001339521.1	neural cell adhesion molecule 2 isoform 3
NM_001352593.2	NP_001339522.1	neural cell adhesion molecule 2 isoform 4 precursor
NM_001352594.2	NP_001339523.1	neural cell adhesion molecule 2 isoform 5 precursor
NM_001352595.2	NP_001339524.1	neural cell adhesion molecule 2 isoform 6 precursor
NM_001352596.2	NP_001339525.1	neural cell adhesion molecule 2 isoform 7 precursor
NM_001352597.2	NP_001339526.1	neural cell adhesion molecule 2 isoform 8
NM_004540.5	NP_004531.2	neural cell adhesion molecule 2 isoform 2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	21300289	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NCAM2 Protein Structure

I-set

fn3

0
200
400
600
837 a.a.

Protein Preferred Names

Protein Names

neural cell adhesion molecule 2

N-CAM-2

NCAM2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NCAM2	O15394	HNRNPC	Homo sapiens	P07910	Crosslink	30021884
Intra	NCAM2	O15394	NCAM2	Homo sapiens	O15394	GMS	21300289
Intra	NCAM2	O15394	SCG3	Homo sapiens	Q8WXD2	Y2H Fragment Pooling	35914814
Intra	NCAM2	O15394	SCHIP1	Homo sapiens	P0DPB3	Display Tech	20195357
Intra	NCAM2	O15394	CTNND2	Homo sapiens	Q9UQB3	Y2H Fragment Pooling	35914814
Intra	NCAM2	O15394	YWHAH	Homo sapiens	Q04917	Y2H Fragment Pooling	35914814
Intra	NCAM2	O15394	CHD4	Homo sapiens	Q14839	Y2H Fragment Pooling	35914814
Intra	NCAM2	O15394	YWHAB	Homo sapiens	P31946	Y2H Fragment Pooling	35914814
Intra	NCAM2	O15394	NCAM2	Homo sapiens	O15394	X-Ray Diffraction	21300289
Intra	NCAM2	O15394	YWHAZ	Homo sapiens	P63104-1	Y2H Fragment Pooling	35914814
Intra	NCAM2	O15394	YWHAE	Homo sapiens	P62258	Y2H Fragment Pooling	35914814
Intra	NCAM2	O15394	RALY	Homo sapiens	Q9UKM9	Crosslink	30021884
Intra	NCAM2	O15394	NCAM2	Homo sapiens	O15394	SAXS	21300289
Intra	NCAM2	O15394	YWHAG	Homo sapiens	P61981	Y2H Fragment Pooling	35914814

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NCAM2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76505	OCAM/NCAM2 Protein, Human (HEK293, Fc)	O15394-1/NP_004531.2 (L20-N697)	≥95%
HY-P76506	OCAM/NCAM2 Protein, Human (HEK293, His)	O15394-1/NP_004531.2 (L20-N697)	≥95%

Related Diseases

Diseases

Alias

Lissencephaly 3

LIS3	Lissencephaly Due To Tuba1a Mutation
Lissencephaly Type 3	Lissencephaly, Type 3

Epilepsy, Familial Temporal Lobe, 7

Familial Temporal Lobe Epilepsy 7	ETL7
Epilepsy, Temporal Lobe, Familial, Type 7

Spinocerebellar Ataxia 37

Spinocerebellar Ataxia Type 37	SCA37
Spinocerebellar Ataxia With Altered Vertical Eye Movements

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09064	NCAM2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NCAM2	VGNC	VGNC:43637
Bos taurus	NCAM2	VGNC	VGNC:31899
Felis catus	NCAM2	VGNC	VGNC:68422
Rattus norvegicus	NCAM2	RGD	RGD:1303131
Macaca mulatta	NCAM2	VGNC	VGNC:75137
Mus musculus	NCAM2	MGD	MGI:97282
Others	NCAM2	NCBI

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