2. Gene
  3. HNRNPC - heterogeneous nuclear ribonucleoprotein C Gene

HNRNPC - heterogeneous nuclear ribonucleoprotein C Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as C1; C2; HNRNP; HNRPC; SNRPC

Gene ID: 3183 | Gene type: protein coding

About HNRNPC

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:21,209,147-21,269,442 (from NCBI)

This gene has 32 transcripts (splice variants), 97 orthologues and 6 paralogues. Ubiquitous expression in lymph node (RPKM 82.0), bone marrow (RPKM 78.3) and 25 other tissues.

Summary

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and Other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

HNRNPC Products(4)

mRNA Protein Name
NM_001077442.2 NP_001070910.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform a
NM_001077443.2 NP_001070911.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform b
NM_004500.4 NP_004491.2 heterogeneous nuclear ribonucleoproteins C1/C2 isoform b
NM_031314.3 NP_112604.2 heterogeneous nuclear ribonucleoproteins C1/C2 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables N6-methyladenosine-containing RNA reader activity IDA
IDA: Inferred from direct assay
25719671 GOA
enables RNA binding IPI
IPI: Inferred from physical interaction
18082603 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables mRNA 3'-UTR binding IDA
IDA: Inferred from direct assay
16010978 GOA
enables poly(U) RNA binding IDA
IDA: Inferred from direct assay
16010978 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11546873 GOA
enables telomerase RNA binding IPI
IPI: Inferred from physical interaction
18082603 GOA
Biological Process GO Annotation Evidence Reference Source
involved in 3'-UTR-mediated mRNA stabilization IMP
IMP: Inferred from mutant phenotype
16010978 GOA
involved in mRNA splicing, via spliceosome IMP
IMP: Inferred from mutant phenotype
25719671 GOA
involved in negative regulation of telomere maintenance via telomerase IMP
IMP: Inferred from mutant phenotype
18082603 GOA
Cellular Component GO Annotation Evidence Reference Source
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
11687588 GOA
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
located in cytosol IDA
IDA: Inferred from direct assay
16010978 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11687588 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
11687588 GOA
part of spliceosomal complex IDA
IDA: Inferred from direct assay
9731529 GOA
part of telomerase holoenzyme complex IDA
IDA: Inferred from direct assay
18082603 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HNRNPC Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (18 - 80)

  • 0
  • 100
  • 200
  • 306 a.a.
Protein Preferred Names Protein Names

heterogeneous nuclear ribonucleoproteins C1/C2

heterogeneous nuclear ribonucleoprotein C (C1/C2)

HNRNPC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
HNRNPC P07910 SUMO1P1 Homo sapiens G2XKQ0
Y2H Prey Pooling
25416956
Intra
HNRNPC P07910 SUMO1P1 Homo sapiens G2XKQ0
Validated Y2H
25416956
Intra
HNRNPC P07910 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
25416956
Intra
HNRNPC P07910 HNRNPCL1 Homo sapiens O60812
Anti Tag CoIP
33961781
Intra
HNRNPC P07910 HNRNPCL1 Homo sapiens O60812
Y2H Prey Pooling
32296183
Intra
HNRNPC P07910 HNRNPCL1 Homo sapiens O60812
Y2H Array
32296183
Intra
HNRNPC P07910 RALYL Homo sapiens Q86SE5-3
Validated Y2H
32296183
Intra
HNRNPC P07910 RALYL Homo sapiens Q86SE5-3
Y2H Array
32296183
Intra
HNRNPC P07910 RALYL Homo sapiens Q86SE5-3
Y2H Prey Pooling
32296183
Intra
HNRNPC P07910 RBPMS2 Homo sapiens Q6ZRY4
Validated Y2H
32296183
Intra
HNRNPC P07910 RBPMS2 Homo sapiens Q6ZRY4
Y2H Array
32296183
Intra
HNRNPC P07910 RBPMS2 Homo sapiens Q6ZRY4
Y2H Prey Pooling
32296183
Intra
HNRNPC P07910 DISC1 Homo sapiens Q9NRI5-2
Y2H Prey Pooling
32296183
Intra
HNRNPC P07910 DISC1 Homo sapiens Q9NRI5-2
Validated Y2H
32296183
Intra
HNRNPC P07910 DISC1 Homo sapiens Q9NRI5-2
Y2H Array
32296183
Intra
HNRNPC P07910 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
HNRNPC P07910 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
HNRNPC P07910 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
HNRNPC P07910 SHANK3 Homo sapiens Q9BYB0
Anti Tag CoIP
21653829
Intra
HNRNPC P07910 SHANK3 Homo sapiens Q9BYB0
Y2H Pooling
21653829
Intra
HNRNPC P07910 RNF4 Homo sapiens P78317
Y2H Prey Pooling
32296183
Intra
HNRNPC P07910 RNF4 Homo sapiens P78317
Validated Y2H
32296183
Intra
HNRNPC P07910 RNF4 Homo sapiens P78317
Y2H Array
32296183
Intra
HNRNPC P07910 HNRNPA2B1 Homo sapiens P22626
Crosslink
30021884
Intra
HNRNPC P07910 HNRNPA2B1 Homo sapiens P22626
Anti Tag CoIP
35271311
Intra
HNRNPC P07910 HNRNPD Homo sapiens Q14103
Anti Tag CoIP
35271311
Intra
HNRNPC P07910 YWHAZ Homo sapiens P63104
Pull Down
15161933
Intra
HNRNPC P07910 KPNA2 Homo sapiens P52292
Y2H Array
25416956
Intra
HNRNPC P07910 HNRNPA1 Homo sapiens P09651
Anti Tag CoIP
35271311
Intra
HNRNPC P07910 HNRNPA1 Homo sapiens P09651
Crosslink
30021884
Intra
HNRNPC P07910 HNRNPA1 Homo sapiens P09651
Anti Bait CoIP
11546873
Intra
HNRNPC P07910 HNRNPC Homo sapiens P07910
Y2H Pooling
16189514
Intra
HNRNPC P07910 HNRNPC Homo sapiens P07910
Validated Y2H
32296183
Intra
HNRNPC P07910 HNRNPC Homo sapiens P07910
Y2H Array
25416956
Intra
HNRNPC P07910 KPNA4 Homo sapiens O00629
Anti Tag CoIP
35271311
Intra
HNRNPC P07910 KPNA4 Homo sapiens O00629
Y2H Array
32296183
Intra
HNRNPC P07910 KPNA4 Homo sapiens O00629
FPS
35044719
Intra
HNRNPC P07910 KPNA3 Homo sapiens O00505
Y2H Prey Pooling
25416956
Intra
HNRNPC P07910 HNRNPC Homo sapiens P07910
Pull Down
16189514
Intra
HNRNPC P07910 HNRNPC Homo sapiens P07910
Y2H Array
32296183
Intra
HNRNPC P07910 KPNA3 Homo sapiens O00505
Anti Tag CoIP
35271311
Intra
HNRNPC P07910 HNRNPC Homo sapiens P07910
Y2H
22365833
Intra
HNRNPC P07910 HNRNPC Homo sapiens P07910
Y2H Prey Pooling
32296183
Intra
HNRNPC P07910 KPNA4 Homo sapiens O00629
Validated Y2H
25416956
Intra
HNRNPC P07910 KPNA4 Homo sapiens O00629
Y2H Prey Pooling
32296183
Intra
HNRNPC P07910 KPNA3 Homo sapiens O00505
Y2H Pooling
16189514
Intra
HNRNPC P07910 KPNA3 Homo sapiens O00505
Y2H Pooling
19447967
Intra
HNRNPC P07910 HNRNPC Homo sapiens P07910
Y2H
21516116
Intra
HNRNPC P07910 TARDBP Homo sapiens Q13148
Y2H Pooling
32814053
Intra
HNRNPC P07910 TARDBP Homo sapiens Q13148
Validated Y2H
32814053
Intra
HNRNPC P07910 TARDBP Homo sapiens Q13148
Y2H Array
32814053
Intra
HNRNPC P07910 CDC5L Homo sapiens Q99459
Anti Tag CoIP
33961781
Intra
HNRNPC P07910 EPS8 Homo sapiens Q12929
Y2H Prey Pooling
25416956
Intra
HNRNPC P07910 HTT Homo sapiens P42858
Y2H Array
32814053
Intra
HNRNPC P07910 HTT Homo sapiens P42858
Pull Down
17500595
Intra
HNRNPC P07910 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra
HNRNPC P07910 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra
HNRNPC P07910 KPNA5 Homo sapiens O15131
Y2H Array
32296183
Intra
HNRNPC P07910 KPNA5 Homo sapiens O15131
Y2H Prey Pooling
32296183
Intra
HNRNPC P07910 SRPK2 Homo sapiens P78362
Protein Kinase Assay
23602568
Intra
HNRNPC P07910 RALY Homo sapiens Q9UKM9
Anti Tag CoIP
33961781
Intra
HNRNPC P07910 SDCBP Homo sapiens O00560
Y2H Array
32296183
Intra
HNRNPC P07910 SDCBP Homo sapiens O00560
Y2H Prey Pooling
25416956
Intra
HNRNPC P07910 SDCBP Homo sapiens O00560
Y2H Prey Pooling
32296183
Intra
HNRNPC P07910 LMO2 Homo sapiens P25791
Y2H Array
25416956
Intra
HNRNPC P07910 RBM41 Homo sapiens Q96IZ5
Y2H Pooling
16189514
Intra
HNRNPC P07910 RBM41 Homo sapiens Q96IZ5
Y2H Array
25416956
Intra
HNRNPC P07910 RBM41 Homo sapiens Q96IZ5
Y2H
21516116
Intra
HNRNPC P07910 RALYL Homo sapiens Q86SE5
Validated Y2H
25416956
Intra
HNRNPC P07910 RALYL Homo sapiens Q86SE5
Y2H Pooling
19447967
Intra
HNRNPC P07910 RALYL Homo sapiens Q86SE5
Y2H Prey Pooling
25416956
Intra
HNRNPC P07910 RALYL Homo sapiens Q86SE5
Y2H Array
25416956
Intra
HNRNPC P07910 RALYL Homo sapiens Q86SE5
Y2H Pooling
16189514
Intra
HNRNPC P07910 PAX6 Homo sapiens P26367
Y2H Prey Pooling
32296183
Intra
HNRNPC P07910 PAX6 Homo sapiens P26367
Validated Y2H
32296183
Intra
HNRNPC P07910 PAX6 Homo sapiens P26367
Y2H Array
32296183
Intra
HNRNPC P07910 SUMO1 Homo sapiens P63165
Validated Y2H
25416956
Intra
HNRNPC P07910 SUMO1 Homo sapiens P63165
Y2H Prey Pooling
32296183
Intra
HNRNPC P07910 SUMO1 Homo sapiens P63165
Validated Y2H
32296183
Intra
HNRNPC P07910 SUMO1 Homo sapiens P63165
Y2H Array
32296183
Intra
HNRNPC P07910 ZFYVE26 Homo sapiens Q68DK2-5
Y2H Array
25416956
Intra
HNRNPC P07910 ZFYVE26 Homo sapiens Q68DK2-5
Validated Y2H
25416956
Intra
HNRNPC P07910 HNRNPCL2 Homo sapiens B2RXH8
Y2H Array
32296183
Intra
HNRNPC P07910 HNRNPCL2 Homo sapiens B2RXH8
Y2H Prey Pooling
32296183
Intra
HNRNPC P07910 RALY Homo sapiens Q53GL6
Validated Y2H
32296183
Intra
HNRNPC P07910 RALY Homo sapiens Q53GL6
Y2H Array
32296183
Intra
HNRNPC P07910 RALY Homo sapiens Q53GL6
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

HNRNPC Antibodies

Cat. No. Product Name Application Reactivity
HY-P82129 hnRNP C1/C2 Antibody (YA1874) WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Mixed Connective Tissue Disease

Sharp Syndrome

Mctd

Connective Tissue Disease Overlap Syndrome

Mixed Collagen Vascular Disease

Mctd - [Mixed Connective Tissue Disease]
Oculopharyngeal Muscular Dystrophy

OPMD

Muscular Dystrophy, Oculopharyngeal

Dystrophy, Oculopharyngeal Muscular

Oculopharyngeal Dystrophy

Progressive Muscular Dystrophy, Oculopharyngeal Type

Muscular Dystrophy Oculopharyngeal

Dystrophy, Muscular, Oculopharyngeal
Connective Tissue Disease

Connective Tissue Diseases

Connective Tissue Disorder

Abnormality Of Connective Tissue

Disorder Of Connective Tissue

Connective Tissue Disorders
Multisystem Proteinopathy
Muscular Atrophy

Muscle Wasting

Amyotrophia

Wasting - Muscle

Skeletal Muscle Atrophy
Fragile X-Associated Tremor/Ataxia Syndrome

Fxtas Syndrome

Fragile X Tremor/Ataxia Syndrome

Fxtas
Muscular Dystrophy

Muscular Dystrophies

Congenital Md

Congenital Muscular Dystrophy

Cmd

Mdc

Dystrophy, Muscular

Gower'S Muscular Dystrophy

Progressive Musclular Dystrophy

Pseudohypertrophic Atrophy

Pseudohypertrophic Muscle Paralysis

Pseudohypertrophic Muscular Atrophy

Pseudohypertrophic Muscular Dystrophy

Pseudohypertrophic Paralysis

Pseudomuscular Hypertrophy
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1

FTDALS1

Frontotemporal Dementia And/Or Motor Neuron Disease

Ftdmnd

Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia

Alsftd

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1

Frontotemporal Dementia With Motor Neuron Disease

Ftdals

Ftd-Als

Ftd-Mnd

Frontotemporal Dementia With Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1

Amyotrophic Lateral Sclerosis/Frontotemporal Dementia

Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1

Frontotemporal Lobar Degeneration

Grn-Related Frontotemporal Dementia
Frontotemporal Dementia

Pallidopontonigral Degeneration

Frontotemporal Lobar Degeneration

Semantic Dementia

FTD

Frontotemporal Lobe Dementia

Multiple System Tauopathy With Presenile Dementia

Dementia, Frontotemporal

Frontotemporal Dementia With Parkinsonism

Mstd

Frontotemporal Lobar Degeneration With Tau Inclusions

Ftld With Tau Inclusions

Dementia, Frontotemporal, With Parkinsonism

Fldem

Ftdp17

Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

Ddpac

Wilhelmsen-Lynch Disease

Wld

Ppnd

Dementia, Frontotemporal, With Or Without Parkinsonism

Semantic Primary Progressive Aphasia

Semantic Variant Ppa

Wilhemsen-Lynch Disease

Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

Ftd-Als

Ftld

Pick Complex

Pick Disease Of The Brain

Frontotemporal Dementia With Parkinsonism-17

Grn-Related Frontotemporal Dementia

Frontotemporal Dementia With Motor Neuron Disease

Dementia In Fronto-Temporal Lobar Degeneration

Ftd - [Frontotemporal Dementia]

Temple Dementia

Frontal Lobe Dementia
Wilms Tumor 1

Nephroblastoma

Wilms Tumor

WT1

Wilms' Tumor

Bilateral Wilms Tumor

Wilms Tumor, Type 1

Wilms Tumor, Somatic

Adult Nephroblastoma

Wt1 Disorder

Renal Embryonic Tumor

Adult Kidney Wilms Tumor

Childhood Kidney Wilms Tumor

Nonanaplastic Kidney Wilms Tumor
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06265 HNRNPC Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HNRNPC RGD RGD:1309982
Mus musculus HNRNPC MGD MGI:107795
Macaca mulatta HNRNPC VGNC VGNC:84348