2. Gene
  3. RALY - RALY heterogeneous nuclear ribonucleoprotein Gene

RALY - RALY heterogeneous nuclear ribonucleoprotein Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as P542; HNRPCL2

Gene ID: 22913 | Gene type: protein coding

About RALY

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:33,993,911-34,084,884 (from NCBI)

This gene has 10 transcripts (splice variants), 203 orthologues and 6 paralogues. Ubiquitous expression in bone marrow (RPKM 18.7), testis (RPKM 18.3) and 25 other tissues.

Summary

This gene encodes a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) gene family. This protein may play a role in pre-mRNA splicing and in embryonic development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

RALY Products(2)

mRNA Protein Name
NM_007367.4 NP_031393.2 RNA-binding protein Raly isoform 2
NM_016732.3 NP_057951.1 RNA-binding protein Raly isoform 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
22365833 GOA
Cellular Component GO Annotation Evidence Reference Source
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
located in nucleus IDA
IDA: Inferred from direct assay
22720776 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RALY Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (23 - 85)

  • 0
  • 100
  • 200
  • 306 a.a.
Protein Preferred Names Protein Names

RNA-binding protein Raly

RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog)

RALY Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
RALY Q9UKM9 HNRNPC Homo sapiens P07910
Crosslink
30021884
Intra
RALY Q9UKM9 HNRNPC Homo sapiens P07910
Y2H
22365833
Intra
RALY Q9UKM9 HNRNPC Homo sapiens P07910
Anti Tag CoIP
33961781
Intra
RALY Q9UKM9 FUS Homo sapiens P35637
PLA
30354839
Intra
RALY Q9UKM9 FUS Homo sapiens P35637
IF
30354839
Intra
RALY Q9UKM9 FUS Homo sapiens P35637
Anti Tag CoIP
30354839
Intra
RALY Q9UKM9 HNRNPCL2 Homo sapiens B2RXH8
Crosslink
30021884
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Skin Carcinoma In Situ

Carcinoma In Situ Of Skin

Cutaneous Carcinoma In Situ
Bardet-Biedl Syndrome 1

BBS1

Bardet-Biedl Syndrome 1, Modifier Of

Bardet-Biedl Syndrome

BBS

Bardet-Biedl Syndrome, Type 1

Laurence-Moon-Bardet-Biedl Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15771 Tirabrutinib 99.65% Yes
HY-P3502 Zilucoplan Inhibitor 95.33% Unkown
HY-10405 Pamapimod Inhibitor 99.92% Unkown
HY-15771A Tirabrutinib hydrochloride 99.43% Yes
HY-B0524 Betahistine Modulator 98.04% Unkown
HY-B0524A Betahistine dihydrochloride Modulator 99.82% Unkown
HY-106019 Liarozole Inhibitor 98.83% Yes
HY-110159 (E/Z)-Teriflunomide Inhibitor ≥95.0% Yes
HY-D0237 Betahistine mesylate Modulator 99.90% Unkown
HY-B0160 Lafutidine Antagonist 99.95% Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9924 Ixekizumab Inhibitor 98.90% Unkown
HY-P99661 Inbakicept Activator 98.95% Unkown
Clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Phase
HY-10291 Tarenflurbil Inhibitor 99.96% Phase 3
HY-106019C Liarozole dihydrochloride Inhibitor ≥99.0% Phase 3
HY-14531 Talarozole Inhibitor 99.61% Phase 2
HY-18099A S1RA hydrochloride Antagonist 99.94% Phase 2
HY-147264 Edecesertib Inhibitor 99.86% Phase 2
HY-18099 S1RA Antagonist 99.43% Phase 2
HY-101671 S-methyl-KE-298 ≥98.0% Phase 2
HY-155031 MCI Inhibitor / Phase 2
Inhibitory Antibodies (7)
Cat. No. Product Name Effect
Purity Phase
HY-P99210 Olokizumab Inhibitor / Phase 3
HY-P99252 Itolizumab / Phase 3
HY-P99259 Cabiralizumab Inhibitor 99.59% Phase 2
HY-P99870 Eblasakimab ≥99.0% Phase 2
HY-P99940 Remtolumab Inhibitor 99.24% Phase 2
HY-P99385 Vobarilizumab Inhibitor / Phase 2
HY-P99642 Gimsilumab Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (116)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0142 Phloretin Inhibitor 99.67% Unkown
HY-125099A AFM-30a hydrochloride Inhibitor 99.96% Unkown
HY-108521 HX531 99.87% Unkown
HY-147141 HS-276 Inhibitor 98.59% Unkown
HY-P0204A Endothelin-3, human, mouse, rabbit, rat TFA 99.51% Unkown
HY-111532 (3R,4R)-A2-32-01 Inhibitor 99.73% Unkown
HY-15898 Y-320 99.74% Unkown
HY-108522 PA452 Antagonist ≥99.0% Unkown
HY-100739 RA190 Inhibitor 99.09% Unkown
HY-110275 RA839 98.90% Unkown
HY-50081 CCR2-RA-[R] Antagonist 99.71% Unkown
HY-N2435 [8]-Shogaol 99.93% Unkown
HY-147972 NF-κB/MAPK-IN-1 Inhibitor 98.42% Unkown
HY-118530 Bucillamine Inhibitor 98.87% Yes
HY-136528 RA-9 98.67% Unkown
HY-136563 RA375 99.31% Unkown
HY-N1976 (+)-(3R,8S)-Falcarindiol Inhibitor 98.53% Unkown
HY-W008388 Bz-rA 99.51% Unkown
HY-N1440 Koumine Activator 99.97% Unkown
HY-21545 5'-O-DMT-Bz-rA ≥98.0% Unkown
HY-103046 UbcH5c-IN-1 Inhibitor 99.84% Unkown
HY-103175 PSB36 Antagonist ≥99.0% Unkown
HY-N4260 Ginsenoside Ra2 95.95% Unkown
HY-147660 IMMH001 Agonist 98.10% Unkown
HY-125415 PF-4693627 Inhibitor 99.63% Unkown
HY-N2506 Ginsenoside Ra1 99.88% Unkown
HY-139314 A2B receptor antagonist 2 Antagonist 99.39% Unkown
HY-21703 3'-TBDMS-Bz-rA Phosphoramidite 98.38% Unkown
HY-103174 MRS1334 Antagonist ≥99.0% Unkown
HY-125099 AFM-30a Inhibitor ≥96.0% Unkown
HY-164416 DBCO-Dextran sulfate (MW 40000) 98.35% Unkown
HY-N10790 RA-V 99.63% Unkown
HY-N4259 Ginsenoside Ra3 98.24% Unkown
HY-W018179 5'-DMT-3'-TBDMS-Bz-rA 99.19% Unkown
HY-W006102 Bz-rA Phosphoramidite 97.58% Unkown
HY-104017 DMT-2'-O-MOE-rA(Bz) phosphoramidite ≥98.0% Unkown
HY-P3491 Pegloxenatide Agonist 90.00% Unkown
HY-W114886 DMT-OMe-rA(Bz) ≥97.0% Unkown
HY-W141394 Bz-OMe-rA 99.25% Unkown
HY-100707 IC 86621 Inhibitor 99.06% Unkown
HY-103177 PSB-10 hydrochloride Inhibitor / Unkown
HY-106019A Liarozole hydrochloride Inhibitor / Unkown
HY-106618 Mopidamol Inhibitor / Unkown
HY-107495 Betahistine EP Impurity C Modulator / Unkown
HY-107644 AQ-RA 741 Antagonist / Unkown
HY-107730 NPY5RA-972 Antagonist 98.86% Unkown
HY-117019 LY150310 free base / Unkown
HY-118689 RA-2 Modulator / Unkown
HY-120785A SR1555 hydrochloride Antagonist / Unkown
HY-126640 Phomoxanthone A Inhibitor / Unkown
HY-127150 Clofezone / Unkown
HY-135376 Atorvastatin methyl ester / Unkown
HY-135378 Atorvastatin ethyl ester / Unkown
HY-135453 (-)-Pinocembrin Inhibitor / Unkown
HY-139654 α/β-Hydrolase-IN-1 Inhibitor / Unkown
HY-143290 Antibacterial agent 118 Inhibitor / Unkown
HY-146104 Antimycobacterial agent-1 Inhibitor / Unkown
HY-14750 Rabeximod / Unkown
HY-149064 Antituberculosis agent-9 Inhibitor / Unkown
HY-149581 DprE1-IN-9 Inhibitor / Unkown
HY-150658S DMT-2′O-TBDMS-rA(ac)-1-15N phosphoramidite / Unkown
HY-151472 hCAIX/XII-IN-6 Inhibitor / Unkown
HY-152035 Mycobacterial Zmp1-IN-1 Inhibitor / Unkown
HY-153333 A1/A3 AR antagonist 3 Antagonist / Unkown
HY-154961 Mcl-1 inhibitor 14 / Unkown
HY-154962 Mcl-1 inhibitor 15 Inhibitor / Unkown
HY-163533 CPD-002 Inhibitor / Unkown
HY-163750 KMU-11342 / Unkown
HY-167905 ATL444 Antagonist / Unkown
HY-B0160S Lafutidine-d10 Antagonist / Unkown
HY-B0524AS Betahistine-d3 dihydrochloride Modulator ≥99.0% Unkown
HY-B0524AS1 Betahistine-13C,d3 dihydrochloride Modulator / Unkown
HY-D2279 NFL-NH2 / Unkown
HY-N0142R Phloretin (Standard) Inhibitor / Unkown
HY-N10793 RA-XI / Unkown
HY-N11646 Ganorbiformin B Inhibitor / Unkown
HY-N11650 (22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid Inhibitor / Unkown
HY-N11957 Angeloylbinankadsurin A / Unkown
HY-N12015 Ginsenoside Ra6 / Unkown
HY-N12648 Anemarsaponin E1 / Unkown
HY-N3612 Communic acid Inhibitor / Unkown
HY-P10292 NOTA-Pep-1L / Unkown
HY-P3502A Zilucoplan TFA Inhibitor / Unkown
HY-RS03232 CSF2RA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06673 IL10RA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06676 IL11RA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06688 IL13RA1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06689 IL13RA2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06693 IL15RA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06702 IL17RA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06732 IL20RA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06737 IL22RA1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06738 IL22RA2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06747 IL27RA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06748 IL2RA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06755 IL31RA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06764 IL3RA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06773 IL5RA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS11635 RALY Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-U00449A AGN 193109 sodium Antagonist / Unkown
HY-105934A Ketotrexate sodium / Unkown
HY-113721 BML-244 Inhibitor / Unkown
HY-116472 alpha-RA-F / Unkown
HY-118761 5,6-Epoxyretinoic acid / Unkown
HY-119291 RA642 / Unkown
HY-121435 K-8012 / Unkown
HY-123019 RA-263 / Unkown
HY-125068 RPR203494 Inhibitor / Unkown
HY-126862 AQ-RA 721 / Unkown
HY-13496 JNJ-28312141 Inhibitor / Unkown
HY-137007 SMA-12b Inhibitor / Unkown
HY-161762 RA-0002034 Inhibitor / Unkown
HY-162707 RA-0002323-01 / Unkown
HY-18016 CGI 560 Inhibitor / Unkown
HY-N2876 Anisofolin A Inhibitor / Unkown
HY-U00420 Opioid receptor modulator 1 Modulator / Unkown
Inhibitory Antibodies (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99287 Elsilimomab Inhibitor 95.00% Unkown
HY-P990016 Temtokibart Inhibitor 99.23% Unkown
HY-P9923A Benralizumab (anti-IL5RA ) 99.60% Unkown
HY-P99487 Briobacept 97.66% Unkown
HY-P990086 Vopikitug Inhibitor / Unkown
HY-P99782 Opinercept Inhibitor / Unkown
HY-P990713 Nolavetbart / Unkown
HY-P990719 Efbalropendekin alfa / Unkown
HY-P990776 Vimekofusp / Unkown
HY-P99790 Priliximab / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RALY MGD MGI:97850
Bos taurus RALY VGNC VGNC:33706
Rattus norvegicus RALY RGD RGD:1307228
Canis familiaris RALY VGNC VGNC:45337
Felis catus RALY VGNC VGNC:81167
Macaca mulatta RALY VGNC VGNC:76486