NEU2 - neuraminidase 2 Gene

Homo sapiens

Also known as SIAL2

Gene ID: 4759 | Gene type: protein coding

About NEU2

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:233,032,672-233,035,057 (from NCBI)

This gene has 1 transcript (splice variant), 115 orthologues and 3 paralogues. Low expression observed in reference dataset.

Summary

This gene belongs to a family of glycohydrolytic Enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments. [provided by RefSeq, Jul 2008]

NEU2 Products(1)

mRNA	Protein	Name
NM_005383.2	NP_005374.2	sialidase-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables exo-alpha-sialidase activity	IDA IDA: Inferred from direct assay	14613940	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ganglioside catabolic process	IDA IDA: Inferred from direct assay	14613940	GOA
involved in glycoprotein catabolic process	IDA IDA: Inferred from direct assay	14613940	GOA
involved in oligosaccharide catabolic process	IDA IDA: Inferred from direct assay	14613940	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of catalytic complex	IDA IDA: Inferred from direct assay	26193330	GOA
located in cytosol	IDA IDA: Inferred from direct assay	10561456	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NEU2 Protein Structure

BNR_2

0
100
200
300
380 a.a.

Protein Preferred Names

Protein Names

sialidase-2

N-acetyl-alpha-neuraminidase 2

NEU2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NEU2	Q9Y3R4	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	NEU2	Q9Y3R4	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	NEU2	Q9Y3R4	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25910212
Intra	NEU2	Q9Y3R4	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25910212
Intra	NEU2	Q9Y3R4	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Bait-Prey Pool	25910212

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NEU2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74733	NEU2 Protein, Human (HEK293, His)	Q9Y3R4 (M1-Q380)	≥95%

Related Diseases

Diseases

Alias

Glycoproteinosis

Sialidosis	Mucolipidosis Type I
Mucolipidoses	Cherry Red Spot Myoclonus Syndrome
Mucolipidosis I	Myoclonus Cherry Red Spot Syndrome
Type I Mucolipidosis	Lipomucopolysaccharidosis
Disorders Of Glycoprotein Metabolism	Glycoprotein Storage Disorder

Galactosialidosis

Goldberg Syndrome	Neuraminidase Deficiency With Beta-Galactosidase Deficiency
Ppca Deficiency	GSL
Lysosomal Protective Protein Deficiency	Cathepsin A Deficiency
Neuraminidase/Beta-Galactosidase Expression	Protective Protein/Cathepsin A Deficiency
Ngbe	Cathepsin A Deficiency Of
Lysosomal Protective Protein Deficiency Of	Deficiency Of Cathepsin A
Neuraminidase Beta-Galactosidase Deficiency	Protective Protein Cathepsin A Deficiency

Breast Medullary Carcinoma

Medullary Breast Carcinoma	Medullary Breast Carcinoma With Lymphoid Stroma
Medullary Carcinoma Of Breast

Mucolipidosis

Breast Rhabdomyosarcoma

Rhabdomyosarcoma Of The Breast

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125798	2,3-Dehydro-2-deoxy-N-acetylneuraminic acid	Inhibitor	≥99.0%	Unkown
HY-P1855	HER2/neu (654-662) GP2		98.04%	Unkown
HY-W087187	DOTAGA-anhydride		/	Unkown
HY-121605	RL71		97.44%	Unkown
HY-P10569	Biotin HER-2 substrate peptide		/	Unkown
HY-P5742A	ELAAWCRWGFLLALLPPGIAG TFA		/	Unkown
HY-P5745	TYVPANASL		/	Unkown
HY-RS09216	NEU2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NEU2	MGD	MGI:1344417
Felis catus	NEU2	VGNC	VGNC:80291
Bos taurus	NEU2	VGNC	VGNC:50231
Canis familiaris	NEU2	VGNC	VGNC:54976
Macaca mulatta	NEU2	VGNC	VGNC:75317
Rattus norvegicus	NEU2	RGD	RGD:3164
Others	NEU2	NCBI

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