RL71

Cat. No.: HY-121605 Purity: 97.44%: FAQs
Data Sheet SDS COA Handling Instructions

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RL71 is a curcuminoid anticancer agent that exhibits potent cytotoxicity against a variety of ER-negative breast cancer cells. RL71 (1 μM) induces cell cycle arrest in the G2/M phase and induces apoptosis in SKBr3 cells. RL7 also decreases HER2/neu phosphorylation and increases p27. RL71 also significantly reduced the phosphorylation of Akt and transiently increased the stress kinases JNK1/2 and p38 MAPK. Furthermore, RL71 exhibited anti-angiogenic potential in vitro, inhibiting the migration of HUVEC cells and the ability of these cells to form tubular networks.

For research use only. We do not sell to patients.

RL71 Chemical Structure

CAS No. : 1195795-93-7

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
5 mg	USD 75	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 380	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 540	In-stock	Estimated Time of Arrival: December 31
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500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.39 μM Compound: 574	Antiproliferative activity against human A549 cells assessed as cell viability by WST-1 assay Antiproliferative activity against human A549 cells assessed as cell viability by WST-1 assay	[PMID: 32172081]
A549	IC₅₀	1.7 μM Compound: 5B	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29655083]
L02	IC₅₀	26.4 μM Compound: 5B	Cytotoxicity against human HL7702 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human HL7702 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29655083]
MDA-MB-231	EC₅₀	0.3 μM Compound: B10	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by SRB assay Cytotoxicity against human MDA-MB-231 cells after 72 hrs by SRB assay	[PMID: 20728364]
MDA-MB-231	IC₅₀	0.39 μM Compound: 574	Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability by WST-1 assay Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability by WST-1 assay	[PMID: 32172081]
MDA-MB-468	EC₅₀	0.3 μM Compound: B10	Cytotoxicity against human MDA-MB-468 cells after 72 hrs by SRB assay Cytotoxicity against human MDA-MB-468 cells after 72 hrs by SRB assay	[PMID: 20728364]
MDA-MB-468	IC₅₀	0.39 μM Compound: 574	Antiproliferative activity against human MDA-MB-468 cells assessed as cell viability by WST-1 assay Antiproliferative activity against human MDA-MB-468 cells assessed as cell viability by WST-1 assay	[PMID: 32172081]
MG-63	IC₅₀	0.39 μM Compound: 574	Antiproliferative activity against human MG-63 cells assessed as cell viability by WST-1 assay Antiproliferative activity against human MG-63 cells assessed as cell viability by WST-1 assay	[PMID: 32172081]
MV4-11	IC₅₀	0.39 μM Compound: 574	Antiproliferative activity against human MV4-11 cells assessed as cell viability by WST-1 assay Antiproliferative activity against human MV4-11 cells assessed as cell viability by WST-1 assay	[PMID: 32172081]
NCI-H1650	IC₅₀	1.5 μM Compound: 5B	Cytotoxicity against human NCI-H1650 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human NCI-H1650 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29655083]
NCI-H1975	IC₅₀	1 μM Compound: 5B	Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29655083]
NCI-H23	IC₅₀	0.39 μM Compound: 574	Antiproliferative activity against human NCI-H23 cells assessed as cell viability by WST-1 assay Antiproliferative activity against human NCI-H23 cells assessed as cell viability by WST-1 assay	[PMID: 32172081]
NCI-H460	IC₅₀	1 μM Compound: 5B	Cytotoxicity against human H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29655083]
SK-BR-3	IC₅₀	0.4 μM Compound: B10	Cytotoxicity against human SKBR3 cells after 72 hrs by SRB assay Cytotoxicity against human SKBR3 cells after 72 hrs by SRB assay	[PMID: 20728364]

Molecular Weight

469.53

Formula

C₂₆H₃₁NO₇

CAS No.

1195795-93-7

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1/C(CN(C/C1=C\C2=CC(OC)=C(C(OC)=C2)OC)C)=C/C3=CC(OC)=C(C(OC)=C3)OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (212.98 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1298 mL	10.6489 mL	21.2979 mL
5 mM	0.4260 mL	2.1298 mL	4.2596 mL
10 mM	0.2130 mL	1.0649 mL	2.1298 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 97.44%

Select Batch:

Data Sheet (270 KB) SDS (251 KB)

COA (247 KB) HNMR (255 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. RL71, a second-generation curcumin analog, induces apoptosis and downregulates Akt in ER-negative breast cancer cells

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1298 mL	10.6489 mL	21.2979 mL	53.2447 mL
	5 mM	0.4260 mL	2.1298 mL	4.2596 mL	10.6489 mL
	10 mM	0.2130 mL	1.0649 mL	2.1298 mL	5.3245 mL
	15 mM	0.1420 mL	0.7099 mL	1.4199 mL	3.5496 mL
	20 mM	0.1065 mL	0.5324 mL	1.0649 mL	2.6622 mL
	25 mM	0.0852 mL	0.4260 mL	0.8519 mL	2.1298 mL
	30 mM	0.0710 mL	0.3550 mL	0.7099 mL	1.7748 mL
	40 mM	0.0532 mL	0.2662 mL	0.5324 mL	1.3311 mL
	50 mM	0.0426 mL	0.2130 mL	0.4260 mL	1.0649 mL
	60 mM	0.0355 mL	0.1775 mL	0.3550 mL	0.8874 mL
	80 mM	0.0266 mL	0.1331 mL	0.2662 mL	0.6656 mL
	100 mM	0.0213 mL	0.1065 mL	0.2130 mL	0.5324 mL

RL71 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RL711195795-93-7RL 71RL-71OthersInhibitorinhibitorinhibit

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RL71

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Complete Stock Solution Preparation Table

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