2. Antibody-drug Conjugate/ADC Related JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. Radionuclide-Drug Conjugates (RDCs) EGFR
  4. DOTAGA-anhydride

DOTAGA-anhydride is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide drug conjugates (RDCs). DOTAGA-anhydride can be used to label monoclonal antibodies (mAbs) such as trastuzumab (targeting HER2/neu receptor with an affinity of 5.5 nM) under mild conditions (PBS pH 7.4, 25 °C, 30 minutes) after chelation with indium-111. [111In-DOTAGA]-trastuzumab showed a tumor uptake of 65% ID/g in mice bearing breast cancer BT-474 xenografts 72 hours after injection, which is valuable for SPECT/CT imaging and biodistribution studies.

For research use only. We do not sell to patients.

DOTAGA-anhydride Chemical Structure

DOTAGA-anhydride Chemical Structure

CAS No. : 1375475-53-8

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

DOTAGA-anhydride Related Antibodies

Top Publications Citing Use of Products

View All Radionuclide-Drug Conjugates (RDCs) Isoform Specific Products:

View All Isoforms
RDC Peptide RDC Antibody RDC Bifunctional Chelator RDC Linker Other

View All EGFR Isoform Specific Products:

View All Isoforms
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • Biological Activity

  • Purity & Documentation

  • Customer Review

Description

DOTAGA-anhydride is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide drug conjugates (RDCs). DOTAGA-anhydride can be used to label monoclonal antibodies (mAbs) such as trastuzumab (targeting HER2/neu receptor with an affinity of 5.5 nM) under mild conditions (PBS pH 7.4, 25 °C, 30 minutes) after chelation with indium-111. [111In-DOTAGA]-trastuzumab showed a tumor uptake of 65% ID/g in mice bearing breast cancer BT-474 xenografts 72 hours after injection, which is valuable for SPECT/CT imaging and biodistribution studies.

IC50 & Target

RDC Bifunctional Chelator

 

Molecular Weight

458.46

Formula

C19H30N4O9
CAS No.
SMILES

O=C(O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(C(CCC(O2)=O)C2=O)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 70 mg/mL (152.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1812 mL 10.9061 mL 21.8122 mL
5 mM 0.4362 mL 2.1812 mL 4.3624 mL
View the Complete Stock Solution Preparation Table

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1812 mL 10.9061 mL 21.8122 mL 54.5304 mL
5 mM 0.4362 mL 2.1812 mL 4.3624 mL 10.9061 mL
10 mM 0.2181 mL 1.0906 mL 2.1812 mL 5.4530 mL
15 mM 0.1454 mL 0.7271 mL 1.4541 mL 3.6354 mL
20 mM 0.1091 mL 0.5453 mL 1.0906 mL 2.7265 mL
25 mM 0.0872 mL 0.4362 mL 0.8725 mL 2.1812 mL
30 mM 0.0727 mL 0.3635 mL 0.7271 mL 1.8177 mL
40 mM 0.0545 mL 0.2727 mL 0.5453 mL 1.3633 mL
50 mM 0.0436 mL 0.2181 mL 0.4362 mL 1.0906 mL
60 mM 0.0364 mL 0.1818 mL 0.3635 mL 0.9088 mL
80 mM 0.0273 mL 0.1363 mL 0.2727 mL 0.6816 mL
100 mM 0.0218 mL 0.1091 mL 0.2181 mL 0.5453 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

DOTAGA-anhydride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DOTAGA-anhydride1375475-53-8Radionuclide-Drug Conjugates (RDCs)EGFREpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
DOTAGA-anhydride
Cat. No.:
HY-W087187
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.