NEUROG1 - neurogenin 1 Gene

Homo sapiens

Also known as AKA; ngn1; Math4C; bHLHa6; NEUROD3

Gene ID: 4762 | Gene type: protein coding

About NEUROG1

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:135,534,282-135,535,964 (from NCBI)

This gene has 1 transcript (splice variant), 127 orthologues and 15 paralogues.

Summary

Enables E-box binding activity and protein homodimerization activity. Involved in several processes, including animal organ morphogenesis; cranial nerve development; and hard palate morphogenesis. Predicted to be located in neuronal cell body. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

NEUROG1 Products(1)

mRNA	Protein	Name
NM_006161.3	NP_006152.2	neurogenin-1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	EXP EXP: Inferred from Experiment	20102160	GOA
enables E-box binding	IDA IDA: Inferred from direct assay	20102160	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	20102160	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	20102160	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in auditory behavior	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in cochlea development	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in cochlea morphogenesis	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in craniofacial suture morphogenesis	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in genitalia development	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in genitalia morphogenesis	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in hard palate morphogenesis	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in inner ear development	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in inner ear morphogenesis	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in learned vocalization behavior	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in mastication	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in negative regulation of relaxation of muscle	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in negative regulation of saliva secretion	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in neuromuscular process controlling balance	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in peristalsis	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in regulation of muscle organ development	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in thorax and anterior abdomen determination	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in trigeminal nerve development	IGI IGI: Inferred from genetic interaction	23419067	GOA
involved in vestibulocochlear nerve formation	IGI IGI: Inferred from genetic interaction	23419067	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NEUROG1 Protein Structure

HLH

0
100
200
237 a.a.

Protein Preferred Names

Protein Names

neurogenin-1

NGN-1

NEUROG1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NEUROG1	Q92886	TCF12	Homo sapiens	Q99081-3	Y2H Prey Pooling	32296183
Intra	NEUROG1	Q92886	TCF12	Homo sapiens	Q99081-3	Validated Y2H	32296183
Intra	NEUROG1	Q92886	TCF12	Homo sapiens	Q99081-3	Y2H Array	32296183
Intra	NEUROG1	Q92886	KLK6	Homo sapiens	Q92876	Y2H Pooling	32814053
Intra	NEUROG1	Q92886	KLK6	Homo sapiens	Q92876	Validated Y2H	32814053
Intra	NEUROG1	Q92886	KLK6	Homo sapiens	Q92876	Y2H Array	32814053
Intra	NEUROG1	Q92886	TCF4	Homo sapiens	P15884	Anti Tag CoIP	33961781
Intra	NEUROG1	Q92886	TCF4	Homo sapiens	P15884	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cerebellar Liponeurocytoma

Lipomatous Medulloblastoma

Central Neurocytoma

Deafness, Autosomal Dominant 52

DFNA52	Autosomal Dominant Nonsyndromic Deafness 52
Deafness, Autosomal Dominant 42	Dfna42
Autosomal Dominant Deafness 52

Cecum Carcinoma

Cecum Cancer	Caecum Carcinoma
Carcinoma Of Cecum	Cecal Cancer
Malignant Neoplasm Of Caecum	Malignant Tumor Of The Cecum

Cerebral Primitive Neuroectodermal Tumor

Pnet Of Cerebrum

Cerebellum Cancer

Cerebellar Neoplasms	Cerebellar Cancer
Malignant Tumor Of Cerebellum	Malignant Neoplasm Of Cerebellum

Lynch Syndrome

Hereditary Nonpolyposis Colon Cancer	Hereditary Nonpolyposis Colorectal Cancer
Hereditary Nonpolyposis Colorectal Carcinoma	Hereditary Nonpolyposis Colorectal Neoplasms
Familial Nonpolyposis Colon Cancer	Hnpcc
Coca 1	Hereditary Defective Mismatch Repair Syndrome
Hereditary Non-Polyposis Colon Cancer	Hereditary Non-Polyposis Colon Cancer Syndrome
Hereditary Non-Polyposis Colorectal Cancer	Hereditary Non-Polyposis Colorectal Cancer Syndrome
Hereditary Nonpolyposis Colon Cancer Syndrome	Hereditary Nonpolyposis Colorectal Cancer Syndrome
Hereditary Nonpolyposis Colorectal Neoplasm	Hnpcc - Hereditary Nonpolyposis Colon Cancer
Cancer Family Syndrome	Familial Nonpolyposis Colorectal Cancer
Colon Cancer, Familial Nonpolyposis	Colorectal Neoplasms, Hereditary Nonpolyposis
Cancer, Colorectal, Nonpolyposis, Hereditary	Colorectal Cancer, Hereditary Nonpolyposis, Type 1

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09228	NEUROG1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NEUROG1	VGNC	VGNC:75322
Canis familiaris	NEUROG1	VGNC	VGNC:43756
Bos taurus	NEUROG1	VGNC	VGNC:32021
Mus musculus	NEUROG1	MGD	MGI:107754
Rattus norvegicus	NEUROG1	RGD	RGD:3167

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